A database collects genomes of bacteria and their hosts for the development of antibiotics

DualSeqDB, created with the participation of the CRG and freely accessible, could allow the scientific community to identify which genes bacteria use to infect, and thus develop new drugs.

Databases like DualSeqDB may be key tools for the future of antibiotics. Image by NASA's Marshall Space Flight Center on Foter.com / CC BY-NC

The Centre for Genomic Regulation (CRG) has participated in the recent creation of DualSeqDB, a database with information about how pathogens and their natural hosts change their gene expression during the infection process.

The database contains the results of the massive and simultaneous sequencing of the genome of different bacteria and their hosts during an infection.

With these open access data, the scientific community could identify the genes used by different types of bacteria during the infection process of their hosts and thus create new therapeutic targets.

“Studying gene activity during infection processes using sequencing is one of the most highly cost-effective methods of discovering new drug targets.”
Benjamin Lang, postdoctoral researcher at the CRG and one of the creators of the database

Given the current situation of increasing bacterial resistance, resources such as DualSeqDB offer crucial knowledge for the future of antibiotics.

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