Scientists find a factor to reprogram and increase the number of blood stem cells

A scientific team from the CRG has found the BAZ2B protein is key for the expansion of blood stem cells.

Hematopoietic stem cells are vital for many treatments. Image by Colin Behrens on Pixabay.

Researchers at the Centre for Genomic Regulation (CRG) in collaboration with Columbia University (New York), have found a protein that could play a key role in reprogramming blood cells to hematopoietic stem cells (HSC), as well as in the expansion of the latter, vital for many treatments.

The team has used an algorithm to identify candidate proteins, and out of the eight they found, only the one resulting from the BAZ2B gene has multiplied the number of HSCs from umbilical cord blood.

“Yielding more of these live-saving stem cells will benefit a variety of different patients in the long-term” 
Pia Cosma, group leader at CRG and leading author

These results could lead to the end of the shortage of stem cells, thus breaking down one of the most limiting barriers to the development of powerful stem cell treatments.

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