Not all long-term memories have been short-term memories beforehand, according to a study by the neuropharmacology laboratory at the Department of Experimental and Health Sciences, Pompeu Fabra University (DCEXS-UPF).
“Mice without the protein kinase C gamma gene have good long-term memory, but have problems encoding short-term memory”, explains Maria Gomis-Gonzalez, co-author of the article. She is currently continuing her research at the Hospital del Mar Medical Research Institute (IMIM), another of the PRBB centers.
In addition to memory tests, the researchers, led by Andrés Ozaita, observed that these mice have deficient neuronal activation in the hippocampus, a brain region known to be essential for the generation of memories.
Gomis-González, M., Galera-López, L., Ten-Blanco, M. et al. Protein Kinase C-Gamma Knockout Mice Show Impaired Hippocampal Short-Term Memory While Preserved Long-Term Memory. Mol Neurobiol (2020). https://doi.org/10.1007/s12035-020-02135-6.