Effects of cannabis at the hippocampus

In this image provided by Emma Puighermanal (Neuropharmacology lab, Department of Experimental and Health Sciences, Pompeu Fabra University (DCEXS-UPF)) and obtained by Xavier Sanjuan, from the microscopy service of the UPF, shows a cut of the hippocampus of a mouse. It has been labelled against the kinase p-p70S6K (red), the dendritic marker MAP2 (blue) and the cannabinoide receptor CB1 (green).

After administering Δ9-tetrahidrocannabinol (THC), the main psychoactive component of marihuana, the signalling pathway for mTOR/ p70S6K is activated in the hippocampus. This pathway is responsible for the amnesic effects of cannabis.


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