{"id":51470,"date":"2026-05-13T12:57:51","date_gmt":"2026-05-13T10:57:51","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=51470"},"modified":"2026-05-13T12:57:52","modified_gmt":"2026-05-13T10:57:52","slug":"la-immunoglobulina-d-una-nova-pista-per-entendre-les-allergies","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/la-immunoglobulina-d-una-nova-pista-per-entendre-les-allergies\/","title":{"rendered":"La immunoglobulina D, una nova pista per entendre les al\u00b7l\u00e8rgies"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Per qu\u00e8 algunes persones desenvolupen una al\u00b7l\u00e8rgia i altres no? La resposta t\u00e9 a veure, en part, amb la capacitat del sistema immunitari per aprendre a tolerar subst\u00e0ncies que no representen una amena\u00e7a real, com alguns aliments, el pol\u00b7len o altres elements presents a l\u2019ambient.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Un <a href=\"https:\/\/doi.org\/10.1084\/jem.20251752\" target=\"_blank\" rel=\"noreferrer noopener\">estudi<\/a> internacional liderat per l\u2019<strong><a href=\"https:\/\/www.researchmar.net\/\" target=\"_blank\" rel=\"noreferrer noopener\">Hospital del Mar Research Institute <\/a>(HMRIB)<\/strong> aporta ara una nova pe\u00e7a a aquest trencaclosques. El treball, publicat al <em>Journal of Experimental Medicine<\/em>, posa el focus en la <strong>immunoglobulina D (IgD)<\/strong>, un tipus d\u2019antic\u00f2s encara poc estudiat que podria contribuir a mantenir l\u2019equilibri de la mucosa nasofar\u00edngia, la zona que connecta el nas i la gola.<\/p>\n\n\n\n<div style=\"height:54px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"600\" src=\"https:\/\/ellipse.prbb.org\/wp-content\/uploads\/2026\/05\/Mauricio_Guzman_Xavi_Marcos_Fa_Donata_Martinuzzi_Andrea-Cerutti_Celia_Corral_Vazquez_Martyna_Filipska-1-800x600.jpg\" alt=\"Sis membres de l\u2019equip investigador de l\u2019Hospital del Mar Research Institute que ha estudiat el paper de la immunoglobulina D en la toler\u00e0ncia als al\u00b7l\u00e8rgens.\" class=\"wp-image-51477\" srcset=\"https:\/\/ellipse.prbb.org\/wp-content\/uploads\/2026\/05\/Mauricio_Guzman_Xavi_Marcos_Fa_Donata_Martinuzzi_Andrea-Cerutti_Celia_Corral_Vazquez_Martyna_Filipska-1-800x600.jpg 800w, https:\/\/ellipse.prbb.org\/wp-content\/uploads\/2026\/05\/Mauricio_Guzman_Xavi_Marcos_Fa_Donata_Martinuzzi_Andrea-Cerutti_Celia_Corral_Vazquez_Martyna_Filipska-1-299x224.jpg 299w, https:\/\/ellipse.prbb.org\/wp-content\/uploads\/2026\/05\/Mauricio_Guzman_Xavi_Marcos_Fa_Donata_Martinuzzi_Andrea-Cerutti_Celia_Corral_Vazquez_Martyna_Filipska-1-768x576.jpg 768w, https:\/\/ellipse.prbb.org\/wp-content\/uploads\/2026\/05\/Mauricio_Guzman_Xavi_Marcos_Fa_Donata_Martinuzzi_Andrea-Cerutti_Celia_Corral_Vazquez_Martyna_Filipska-1-1536x1152.jpg 1536w, https:\/\/ellipse.prbb.org\/wp-content\/uploads\/2026\/05\/Mauricio_Guzman_Xavi_Marcos_Fa_Donata_Martinuzzi_Andrea-Cerutti_Celia_Corral_Vazquez_Martyna_Filipska-1-2048x1536.jpg 2048w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><figcaption>D\u2019esquerra a dreta: Mauricio Guzman, Xavi Marcos Fa, Donata Martinuzzi, Andrea Cerutti, Celia Corral Vazquez i Martyna Filipska, membres de l\u2019equip de l\u2019Hospital del Mar Research Institute que ha participat en l\u2019estudi. Font: Hospital del Mar Research Institute.<\/figcaption><\/figure>\n\n\n\n<div style=\"height:54px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">L\u2019equip ha identificat, per primera vegada, les c\u00e8l\u00b7lules que donen lloc a aquests anticossos: unes c\u00e8l\u00b7lules de mem\u00f2ria B espec\u00edfiques, anomenades <strong>c\u00e8l\u00b7lules de mem\u00f2ria IgD<\/strong>, que poden transformar-se en c\u00e8l\u00b7lules plasm\u00e0tiques productores d\u2019IgD. Tamb\u00e9 n\u2019ha situat l\u2019origen a les <strong>am\u00edgdales<\/strong>, un lloc estrat\u00e8gic perqu\u00e8 \u00e9s una de les primeres zones on el cos entra en contacte amb ant\u00edgens que arriben per l\u2019aire o a trav\u00e9s dels aliments.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Aquesta localitzaci\u00f3 <strong>podria ser clau per entendre com el sistema immunitari decideix qu\u00e8 ha de tolerar i davant de qu\u00e8 ha de reaccionar.<\/strong> Segons els autors, si aquest mecanisme falla, es poden afavorir respostes inflamat\u00f2ries com les al\u00b7l\u00e8rgies.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">L\u2019estudi tamb\u00e9 ha analitzat pacients amb diferents immunodefici\u00e8ncies prim\u00e0ries i mostra que <strong>la producci\u00f3 d\u2019IgD dep\u00e8n de diversos senyals reguladors del sistema immunitari<\/strong>. Quan aquests senyals fallen, la IgD pot desapar\u00e8ixer; quan altres vies s\u2019alteren, pot acumular-se en exc\u00e9s.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tot i que encara caldr\u00e0 validar aquesta via en nous estudis, els resultats obren la porta a <strong>explorar futures estrat\u00e8gies terap\u00e8utiques basades en la IgD<\/strong>. L\u2019equip de l\u2019HMRIB ja prepara estudis en models in vivo per analitzar si aquest antic\u00f2s podria ajudar a modular la resposta davant els al\u00b7l\u00e8rgens i, potencialment, en altres malalties relacionades amb la inflamaci\u00f3.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">Llegeix la noticia completa a la web de l&#8217;<a href=\"https:\/\/www.researchmar.net\/noticies\/1455\/descobreixen-un-dels-possibles-mecanismes-que-regulen-la-tolerancia-als-al%c2%b7lergens\" target=\"_blank\" rel=\"noreferrer noopener\">Hospital del Mar Research Institute<\/a>.<\/p>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Un estudi liderat per l\u2019Hospital del Mar Research Institute identifica a les am\u00edgdales les c\u00e8l\u00b7lules que produeixen aquest antic\u00f2s, que podria tenir un paper important en la toler\u00e0ncia als al\u00b7l\u00e8rgens.<\/p>\n","protected":false},"author":37,"featured_media":51474,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[213,411],"new-type":[35],"class_list":["post-51470","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-imim","tag-immunologia","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/51470","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/37"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=51470"}],"version-history":[{"count":13,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/51470\/revisions"}],"predecessor-version":[{"id":51489,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/51470\/revisions\/51489"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/51474"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=51470"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=51470"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=51470"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=51470"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}