{"id":51393,"date":"2026-04-27T17:43:27","date_gmt":"2026-04-27T15:43:27","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=51393"},"modified":"2026-04-28T13:17:13","modified_gmt":"2026-04-28T11:17:13","slug":"un-biomarcador-podria-ajudar-a-identificar-quins-pacients-amb-cancer-colorectal-es-podrien-beneficiar-de-la-immunoterapia","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/un-biomarcador-podria-ajudar-a-identificar-quins-pacients-amb-cancer-colorectal-es-podrien-beneficiar-de-la-immunoterapia\/","title":{"rendered":"Un biomarcador podria ajudar a identificar quins pacients amb c\u00e0ncer colorectal es podrien beneficiar de la immunoter\u00e0pia"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">La immunoter\u00e0pia \u00e9s actualment una opci\u00f3 nom\u00e9s per a una petita proporci\u00f3 de persones amb c\u00e0ncer colorectal. En el cas del c\u00e0ncer de c\u00f2lon, aquesta xifra \u00e9s d\u2019entorn del 5% i, fins i tot aix\u00ed, el tractament no funciona en tots els casos. Ara, investigadors i investigadores liderats per l\u2019<strong><a href=\"https:\/\/www.imim.es\/\">Hospital del Mar Research Institute<\/a><\/strong> i l\u2019<strong><a rel=\"noreferrer noopener\" href=\"https:\/\/www.irbbarcelona.org\/\" target=\"_blank\">IRB Barcelona<\/a><\/strong> han <strong>identificat un biomarcador que podria ajudar els cl\u00ednics a predir millor quins pacients tenen m\u00e9s probabilitats de respondre, alhora que aporta nova informaci\u00f3 sobre el pron\u00f2stic<\/strong>. L\u2019estudi s\u2019ha publicat a <em>Gut<\/em>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">El marcador s\u2019anomena <strong>CTHRC1<\/strong> i no es troba en les mateixes c\u00e8l\u00b7lules tumorals, sin\u00f3 en c\u00e8l\u00b7lules del voltant del tumor conegudes com a <strong>fibroblasts associats al c\u00e0ncer<\/strong>. Aquestes c\u00e8l\u00b7lules formen part del <strong>microambient tumoral<\/strong>: el teixit que envolta el tumor i que contribueix a determinar com creix el c\u00e0ncer, com interactua amb el sistema immunitari i com respon al tractament. Segons l\u2019estudi, la <strong>pres\u00e8ncia<\/strong> d\u2019aquests fibroblasts positius per a CTHRC1 s\u2019associa a una <strong>menor immunogenicitat, pitjors resultats i un benefici m\u00e9s limitat de la immunoter\u00e0pia<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Un dels aspectes m\u00e9s rellevants del treball \u00e9s la seva possible utilitat en contextos cl\u00ednics reals. Els investigadors mostren que aquest biomarcador es pot detectar mitjan\u00e7ant <strong>immunohistoqu\u00edmica<\/strong>, una t\u00e8cnica est\u00e0ndard que s\u2019utilitza de manera rutin\u00e0ria als serveis d\u2019anatomia patol\u00f2gica. Per validar la troballa, l\u2019equip va analitzar 17 cohorts, incloent-hi mostres de prop de 3.000 pacients, i va confirmar els resultats en mostres de diversos hospitals nacionals i internacionals, entre ells l\u2019<a rel=\"noreferrer noopener\" href=\"https:\/\/www.hospitaldelmar.cat\/en\/\" target=\"_blank\">Hospital del Mar<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">M\u00e9s enll\u00e0 d\u2019ajudar a identificar qui es podria beneficiar de la immunoter\u00e0pia, el biomarcador tamb\u00e9 <strong>podria millorar el pron\u00f2stic<\/strong>. L\u2019estudi relaciona nivells elevats de <strong>CTHRC1<\/strong> amb l\u2019activitat de <strong>TGF-beta<\/strong> al microambient tumoral, una via associada a una pitjor evoluci\u00f3 de la malaltia i a resist\u00e8ncia al tractament. En aquest sentit, el treball no nom\u00e9s apunta a un nou marcador cl\u00ednic, sin\u00f3 tamb\u00e9 a un mecanisme biol\u00f2gic que, eventualment, <strong>podria ser una diana terap\u00e8utica<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">En conjunt, els resultats reforcen una idea que ha esdevingut cada cop m\u00e9s important en la recerca en c\u00e0ncer: <strong>per entendre com es comportar\u00e0 un tumor, no n\u2019hi ha prou amb mirar nom\u00e9s el tumor en si<\/strong>. Les c\u00e8l\u00b7lules que l\u2019envolten tamb\u00e9 importen. En el c\u00e0ncer colorectal, aquesta visi\u00f3 m\u00e9s \u00e0mplia podria ajudar ara a afinar les decisions terap\u00e8utiques amb eines que els hospitals ja tenen al seu abast.<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Un equip liderat per l\u2019Hospital del Mar Research Institute i l\u2019IRB Barcelona ha identificat un biomarcador vinculat al pron\u00f2stic i a la probable resposta a la immunoter\u00e0pia en c\u00e0ncer de c\u00f2lon i de recte.<\/p>\n","protected":false},"author":37,"featured_media":51388,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[312,213,413],"new-type":[35],"class_list":["post-51393","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-cancer-ca","tag-imim","tag-immunoterapia","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/51393","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/37"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=51393"}],"version-history":[{"count":3,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/51393\/revisions"}],"predecessor-version":[{"id":51396,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/51393\/revisions\/51396"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/51388"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=51393"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=51393"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=51393"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=51393"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}