{"id":51230,"date":"2026-04-20T11:58:53","date_gmt":"2026-04-20T09:58:53","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=51230"},"modified":"2026-04-20T11:58:55","modified_gmt":"2026-04-20T09:58:55","slug":"el-crg-descobreix-com-el-virus-de-lherpes-simple-remodela-el-genoma-huma-per-reproduir-se","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/el-crg-descobreix-com-el-virus-de-lherpes-simple-remodela-el-genoma-huma-per-reproduir-se\/","title":{"rendered":"El CRG descobreix com el virus de l&#8217;herpes simple remodela el genoma hum\u00e0 per reproduir-se"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Un cop una persona s\u2019infecta amb el <strong>virus de l\u2019herpes hum\u00e0 simple tipus 1 (VHS-1)<\/strong> \u00e9s portadora del virus per sempre. S\u2019estima doncs que uns 3,8 mil milions de persones menors de 50 anys arreu del m\u00f3n estan infectades amb aquest virus. En la majoria de casos, la infecci\u00f3 es asimptom\u00e0tica o causa herpes labial recurrentment. Per\u00f2 en persones immunodeprimides o nadons pot comportar complicacions greus com ceguesa o fins  ser potencialment mortal. Aix\u00ed doncs, la seva prevalen\u00e7a en la poblaci\u00f3 mundial presenta un repte en la salut global que cal adre\u00e7ar.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ara, un <a rel=\"noreferrer noopener\" href=\"https:\/\/www.crg.eu\/es\/news\/herpes-virus-plays-interior-designer-human-dna\" target=\"_blank\">estudi recent<\/a> del <a rel=\"noreferrer noopener\" href=\"https:\/\/www.crg.eu\/\" target=\"_blank\">Centre de Regulaci\u00f3 Gen\u00f2mica (CRG)<\/a> ha descobert un dels mecanismes que l\u2019HSV-1 fa servir per replicar-se dins les c\u00e8l\u00b7lules humanes. El treball mostra que el virus \u00e9s capa\u00e7 de <strong>remodelar de manera precisa l\u2019estructura tridimensional del genoma hum\u00e0<\/strong> per accedir a les regions que m\u00e9s li convenen i aprofitar millor els recursos de l\u2019hoste.<\/p>\n\n\n\n<div style=\"height:33px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u201cVHS-1 \u00e9s un interiorista oportunista que remodela el genoma hum\u00e0 amb gran precisi\u00f3 i tria amb quines parts entra en contacte. \u00c9s un nou mecanisme de manipulaci\u00f3 que no sab\u00edem que tenia el virus per aprofitar els recursos de l\u2019hoste\u201d <br><strong>Esther Gonz\u00e1lez Amela<\/strong><\/p><\/blockquote>\n\n\n\n<div style=\"height:33px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">L&#8217;equip tamb\u00e9 ha observat que inactivant la topoisomerasa I \u2014un enzim que ajuda a alleujar la tensi\u00f3 de l\u2019ADN durant processos clau de transcripci\u00f3 i organitzaci\u00f3 gen\u00f2mica\u2014, el VHS-1 perd la capacitat de reproduir-se.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A la imatge s&#8217;observa com el genoma hum\u00e0 est\u00e0 compactat dins de la c\u00e8l\u00b7lula despr\u00e9s d\u2019haver estat infectada amb el virus de l\u2019herpes. Una figura que s\u2019ha pogut obtenir gr\u00e0cies a la combinaci\u00f3 de <strong>microsc\u00f2pia de superresoluci\u00f3<\/strong> que permet observar estructures de fins a 20 nan\u00f2metres i<strong> Hi-C<\/strong>, una t\u00e8cnica que mostra els fragments d\u2019ADN que es toquen dins del nucli.<\/p>\n\n\n\n<div style=\"height:46px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Un cop una persona s\u2019infecta amb el virus de l\u2019herpes hum\u00e0 simple tipus 1 (VHS-1) \u00e9s portadora del virus per sempre. S\u2019estima doncs que uns 3,8 mil milions de persones menors de 50 anys arreu del m\u00f3n estan infectades amb aquest virus. En la majoria de casos, la infecci\u00f3 es asimptom\u00e0tica o causa herpes labial [&hellip;]<\/p>\n","protected":false},"author":29,"featured_media":50846,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[265,323,475],"new-type":[40],"class_list":["post-51230","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-crg-ca","tag-microscopia","tag-virus-ca","new-type-foto-de-la-setmana"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/51230","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/29"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=51230"}],"version-history":[{"count":10,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/51230\/revisions"}],"predecessor-version":[{"id":51251,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/51230\/revisions\/51251"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/50846"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=51230"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=51230"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=51230"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=51230"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}