{"id":49946,"date":"2025-11-19T14:22:40","date_gmt":"2025-11-19T13:22:40","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=49946"},"modified":"2025-11-19T14:22:48","modified_gmt":"2025-11-19T13:22:48","slug":"fantasia-una-eina-dia-illumina-les-funcions-ocultes-de-24-milions-de-proteines","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/fantasia-una-eina-dia-illumina-les-funcions-ocultes-de-24-milions-de-proteines\/","title":{"rendered":"FANTASIA, una eina d’IA, il\u00b7lumina les funcions ocultes de 24 milions de prote\u00efnes"},"content":{"rendered":"\n

Un innovador estudi<\/a> co-dirigit per Rosa <\/a><\/strong>Fern\u00e1ndez<\/strong> <\/a>a l‘Institut de Biologia Evolutiva (IBE: CSIC-UPF)<\/a> i Ana Rojas <\/strong>al Centre Andal\u00fas de Biologia del Desenvolupament (CABD, CSIC-UPO) ha presentat FANTASIA<\/strong>, una eina d’intel\u00b7lig\u00e8ncia artificial<\/a><\/strong> capa\u00e7 de predir la funci\u00f3 de qualsevol prote\u00efna directament a partir de la seva seq\u00fc\u00e8ncia gen\u00e8tica. <\/strong>Utilitzant els mateixos principis darrere de models de llenguatge com ChatGPT, FANTASIA tracta l’ADN com un llenguatge biol\u00f2gic, desxifrant la seva \u00abgram\u00e0tica\u00bb per inferir el que fa cada prote\u00efna, sense dependre de les comparacions tradicionals entre prote\u00efnes basades en homologia.<\/p>\n\n\n\n

En una an\u00e0lisi exhaustiva de gaireb\u00e9 1.000 genomes animals<\/strong>, FANTASIA va anotar amb \u00e8xit 24 milions de gens pr\u00e8viament no caracteritzats <\/strong>amb notable precisi\u00f3. L‘eina, que \u00e9s d’acc\u00e9s obert, <\/strong>es pot executar de manera eficient en computadores est\u00e0ndard i p\u00e9s capa\u00e7 de processar un genoma complet en nom\u00e9s hores, la qual cosa posa l’an\u00e0lisi gen\u00f2mica d’alt nivell a l’abast de grups de recerca de tot el m\u00f3n. En revelar el \u00abproteoma fosc\u00bb,<\/a> la meitat de totes les prote\u00efnes les funcions de les quals continuen sent desconegudes, FANTASIA proporciona una finestra sense precedents a la complexitat i evoluci\u00f3 de la vida.<\/p>\n\n\n\n

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Tot i que coneixem la funci\u00f3 del voltant del 80-90% de les prote\u00efnes humanes, en altres organismes com els invertebrats, la funci\u00f3 de m\u00e9s de la meitat de totes les prote\u00efnes continua sent un misteri.<\/em><\/p><\/blockquote>\n\n\n\n

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M\u00e9s enll\u00e0 de les seves implicacions evolutives, l’eina t\u00e9 un gran potencial per a la innovaci\u00f3 biom\u00e8dica i biotecnol\u00f2gica<\/strong>. En identificar noves funcions proteiques, FANTASIA podria guiar el descobriment de noves dianes terap\u00e8utiques i enzims. Com ho descriuen les investigadores, aquest \u00abChatGPT de prote\u00efnes\u00bb est\u00e0 destinat a transformar la forma en qu\u00e8 explorem els fonaments moleculars de la vida.<\/p>\n\n\n\n

\u00abSabem que altres grups de recerca de tot el m\u00f3n ja estan utilitzant FANTASIA i que funciona no nom\u00e9s en animals, sin\u00f3 tamb\u00e9 en plantes, virus, fongs i protistes. El potencial per descobrir nous gens que podrien revolucionar la biotecnologia, la medicina o la conservaci\u00f3 de la biodiversitat \u00e9s il\u00b7limitat<\/strong>\u00ab, conclou Fern\u00e1ndez.<\/p>\n\n\n\n

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Una eina d’IA d’acc\u00e9s obert co-desenvolupada pel grup de Rosa Fern\u00e1ndez a l’IBE, \u00e9s capa\u00e7 de predir la funci\u00f3 de qualsevol prote\u00efna directament a partir de la seva seq\u00fc\u00e8ncia gen\u00e8tica.<\/p>\n","protected":false},"author":6,"featured_media":49936,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[283,859,211,329],"new-type":[35],"class_list":["post-49946","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-evolucio","tag-ia","tag-ibe-csic-upf","tag-proteines","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/49946","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=49946"}],"version-history":[{"count":6,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/49946\/revisions"}],"predecessor-version":[{"id":49952,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/49946\/revisions\/49952"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/49936"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=49946"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=49946"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=49946"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=49946"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}