{"id":49902,"date":"2025-11-28T09:54:46","date_gmt":"2025-11-28T08:54:46","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=49902"},"modified":"2025-12-04T13:06:21","modified_gmt":"2025-12-04T12:06:21","slug":"la-depressio-resistent-al-tractament-molecularment-diferent-a-la-depressio-comuna","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/la-depressio-resistent-al-tractament-molecularment-diferent-a-la-depressio-comuna\/","title":{"rendered":"La depressi\u00f3 resistent al tractament, molecularment diferent a la depressi\u00f3 comuna"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><a rel=\"noreferrer noopener\" href=\"https:\/\/www.upf.edu\/web\/biomed\/inici\/ca\/-\/asset_publisher\/Us0jfwFAevmx\/content\/depresion-resistente-tratamiento\/229891609\/maximized\" target=\"_blank\">Un estudi internacional ha identificat que la<strong> depressi\u00f3 resistent al tractament (DRT) <\/strong>presenta una biologia diferenciada de la depressi\u00f3 major comuna<\/a>. Analitzant <strong>sang de 300 persones amb trastorn depressiu major<\/strong>, els investigadors i investigadores han descobert <strong>m\u00e9s de 5.000 gens que es comporten de manera diferent<\/strong> en els pacients amb <a href=\"https:\/\/ellipse.prbb.org\/ca\/la-depressio-afecta-a-mes-del-6-de-la-poblacio-europea\/\" target=\"_blank\" rel=\"noreferrer noopener\">depressi\u00f3 <\/a>resistent comparats amb els de depressi\u00f3 no-resistent. Molts d&#8217;aquests gens estan relacionats amb el sistema immunitari, la regulaci\u00f3 gen\u00e8tica i la neuroplasticitat. Aix\u00f2 suggereix que la DRT no \u00e9s nom\u00e9s una forma m\u00e9s greu de depressi\u00f3, sin\u00f3 un subtipus molecular amb mecanismes propis.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">L\u2019<a href=\"https:\/\/www.imim.cat\/noticies\/1390\/identifiquen-la-depressio-resistent-al-tractament-com-un-subtipus-molecular-diferent\" target=\"_blank\" rel=\"noreferrer noopener\">estudi<\/a>, liderat per institucions com l\u2019<a rel=\"noreferrer noopener\" href=\"http:\/\/www.imim.es\/\" target=\"_blank\">Hospital del Mar Research Institute<\/a>, la Universitat Pompeu Fabra, la Universitat de Brescia i el Paris Brain Institute, destaca que <strong>una resposta immunit\u00e0ria redu\u00efda podria explicar per qu\u00e8 els antidepressius habituals sovint no funcionen en aquests casos<\/strong>. Aquesta troballa obre la porta al desenvolupament de tractaments m\u00e9s espec\u00edfics i personalitzats per als pacients amb DRT.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Els resultats formen part del projecte europeu PROMPT, que <strong>utilitza <a href=\"https:\/\/ellipse.prbb.org\/ca\/la-ia-que-ajudara-a-atendre-persones-amb-risc-de-suicidi\/\" target=\"_blank\" rel=\"noreferrer noopener\">eines d\u2019aprenentatge autom\u00e0tic per predir quins pacients<\/a> podrien desenvolupar DRT<\/strong>. Els equips investigadors esperen que la combinaci\u00f3 de dades cl\u00edniques i moleculars permeti crear <strong>models de psiquiatria de precisi\u00f3<\/strong>, algoritmes capa\u00e7os d&#8217;ajustar el tractament segons la biologia de cada pacient i d\u2019evitar ter\u00e0pies ineficaces.<\/p>\n\n\n\n<div style=\"height:63px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Un estudi a nivell molecular, co-dirigit per J\u00falia Perera-Bel del GRIB (Hospital del Mar Research Institute-UPF), podria ajudar al desenvolupament de tractaments m\u00e9s espec\u00edfics per aquest subtipus de depressi\u00f3.<\/p>\n","protected":false},"author":6,"featured_media":49904,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[213,273,317,676],"new-type":[35],"class_list":["post-49902","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-imim","tag-melis-upf-ca","tag-neurobiologia","tag-salut-mental","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/49902","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=49902"}],"version-history":[{"count":10,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/49902\/revisions"}],"predecessor-version":[{"id":50152,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/49902\/revisions\/50152"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/49904"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=49902"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=49902"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=49902"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=49902"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}