{"id":49092,"date":"2026-01-05T10:24:51","date_gmt":"2026-01-05T09:24:51","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=49092"},"modified":"2026-01-05T10:28:34","modified_gmt":"2026-01-05T09:28:34","slug":"un-punt-feble-del-parasit-de-la-malaria","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/un-punt-feble-del-parasit-de-la-malaria\/","title":{"rendered":"Un punt feble del par\u00e0sit de la mal\u00e0ria"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Aquesta imatge de la setmana, presa amb un <strong>microscopi electr\u00f2nic<\/strong>, mostra la <strong>ultraestructura del <em>Plasmodium falciparum<\/em> alterat per PfGNA1<\/strong>. <strong>Presa per Maria Pia Alberione<\/strong>, estudiant de doctorat de <a rel=\"noopener noreferrer\" href=\"https:\/\/www.isglobal.org\/ca\/\" target=\"_blank\">l&#8217;Institut de Salut Global de Barcelona (ISGlobal)<\/a>, la imatge forma part d&#8217;un <a rel=\"noopener noreferrer\" href=\"https:\/\/www.isglobal.org\/ca\/-\/un-punto-debil-en-el-parasito-de-la-malaria\" target=\"_blank\">estudi recent<\/a> que ha descobert una nova forma potencial i segura d&#8217;atacar els <a rel=\"noopener noreferrer\" href=\"https:\/\/ellipse.prbb.org\/ca\/sincronitzant-els-parasits-de-la-malaria\/\" target=\"_blank\">par\u00e0sits de la mal\u00e0ria<\/a>, actuant sobre un dels seus passos metab\u00f2lics clau.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Un dels reptes a l&#8217;hora de<a href=\"https:\/\/ellipse.prbb.org\/ca\/microvasos-cerebrals-per-entendre-els-anticossos-contra-la-malaria\/\" target=\"_blank\" rel=\"noopener noreferrer\"> tractar la mal\u00e0ria<\/a> \u00e9s el fet que els par\u00e0sits <em>Plasmodium<\/em> que causen la malaltia s\u00f3n organismes eucariotes, igual que nosaltres. Aix\u00f2 significa que \u00e9s dif\u00edcil trobar f\u00e0rmacs que siguin letals per a ells per\u00f2 segurs per als \u00e9ssers humans, com \u00e9s el cas dels antibi\u00f2tics, que nom\u00e9s ataquen els bacteris.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">No obstant aix\u00f2, l&#8217;equip d&#8217;ISGlobal, dirigit per <strong>Luis Izquierdo<\/strong>, ha trobat un punt feble en una via metab\u00f2lica que el par\u00e0sit utilitza per fixar prote\u00efnes cr\u00edtiques a la seva superf\u00edcie i ajudar a mantenir la seva estructura. En concret, van observar que l&#8217;<strong>enzim PfGNA1<\/strong>, essencial per a aquesta via, \u00e9s estructuralment <strong>molt diferent del seu equivalent en els \u00e9ssers humans<\/strong>. I quan <strong>van interrompre<\/strong> el gen <em>PfGNA1<\/em> en el par\u00e0sit, van observar una p\u00e8rdua dr\u00e0stica d&#8217;aquestes prote\u00efnes d&#8217;ancoratge, cosa que va provocar una detenci\u00f3 del desenvolupament del par\u00e0sit, impedint la seva fuita dels gl\u00f2buls vermells i <strong>bloquejant efica\u00e7ment noves invasions<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Aquests resultats apunten PfGNA1 com un <strong>possible objectiu per a futurs f\u00e0rmacs<\/strong> que podrien afectar el par\u00e0sit sense atacar les prote\u00efnes humanes.<\/p>\n\n\n\n<div style=\"height:57px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Aquesta imatge de la setmana, presa amb un microscopi electr\u00f2nic, mostra la ultraestructura del Plasmodium falciparum alterat per PfGNA1. Presa per Maria Pia Alberione, estudiant de doctorat de l&#8217;Institut de Salut Global de Barcelona (ISGlobal), la imatge forma part d&#8217;un estudi recent que ha descobert una nova forma potencial i segura d&#8217;atacar els par\u00e0sits de [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":48956,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[295,958],"new-type":[40],"class_list":["post-49092","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-isglobal-cat","tag-malaria-ca","new-type-foto-de-la-setmana"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/49092","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=49092"}],"version-history":[{"count":4,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/49092\/revisions"}],"predecessor-version":[{"id":50341,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/49092\/revisions\/50341"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/48956"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=49092"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=49092"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=49092"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=49092"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}