{"id":49049,"date":"2025-08-25T15:34:56","date_gmt":"2025-08-25T13:34:56","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=49049"},"modified":"2025-08-25T15:34:57","modified_gmt":"2025-08-25T13:34:57","slug":"how-the-malaria-parasite-traverses-the-blood-brain-barrier","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/how-the-malaria-parasite-traverses-the-blood-brain-barrier\/","title":{"rendered":"Com el par\u00e0sit de la mal\u00e0ria travessa la barrera hematoencef\u00e0lica"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>La mal\u00e0ria cerebral<\/strong>, quan la infecci\u00f3 per <em>Plasmodium falciparum<\/em> aconsegueix travessar la <a href=\"https:\/\/ellipse.prbb.org\/ca\/el-mur-protector-del-cervell-la-barrera-hematoencefalica\/\" target=\"_blank\" rel=\"noreferrer noopener\">barrera hematoencef\u00e0lica (BBB)<\/a> i arribar al cervell, \u00e9s una complicaci\u00f3 greu d&#8217;aquesta malaltia tropical i t\u00e9 altes taxes de mortalitat, fins i tot despr\u00e9s del tractament amb antipal\u00fadics efectius.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Els models experimentals actuals per tractar d\u2019estudiar aquesta etapa de la mal\u00e0ria s\u00f3n limitats. Per\u00f2 un equip del <a rel=\"noreferrer noopener\" href=\"https:\/\/www.embl.es\/\" target=\"_blank\">Laboratori Europeu de Biologia Molecular \u2013 Barcelona (EMBL Barcelona)<\/a> dirigit per <strong>Maria Bernabeu <\/strong>ha desenvolupat un <strong>Model 3D de barrera hematoencef\u00e0lica (BBB)<\/strong>, que ha utilitzat per proporcionar nous coneixements sobre com el par\u00e0sit aconsegueix impulsar la patog\u00e8nesi microvascular cerebral.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">La foto d&#8217;adalt mostra imatges de projecci\u00f3 z del seu model de <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/microvasos-cerebrals-per-entendre-els-anticossos-contra-la-malaria\/\" target=\"_blank\">microvasos 3D-BBB fets gr\u00e0cies a la<strong> bioenginyeria<\/strong><\/a>, fabricats en un hidrogel de col\u00b7lagen tipus I. En ella, podem observar l\u2019organitzaci\u00f3 espaial dels tres tipus de c\u00e8l\u00b7lules que formen el microvas:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Les c\u00e8l\u00b7lules <strong>endotelials microvasculars del cervell<\/strong>, que formen l\u2019interior dels vasos sanguinis, es tenyeixen de <strong>blanc <\/strong>(marcant la prote\u00efna VE-cadherina).<\/li><li>Els <strong>astr\u00f2cits primaris<\/strong>, el tipus principal de c\u00e8l\u00b7lules nervioses, es veuen en <strong>verd <\/strong>(a trav\u00e9s d\u2019una construcci\u00f3 GFP).<\/li><li>Els <strong>pericits<\/strong>, un tipus de c\u00e8l\u00b7lules que es troben a les parets dels petits vasos sanguinis i que ajuden a mantenir la seva integritat, estan etiquetats en <strong>rosa<\/strong>.<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">En <strong>blau<\/strong>, podem veure tots els <strong>nuclis <\/strong>cel\u00b7lulars.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Utilitzant aquest model de BBB, els autors i autores han demostrat en un <a rel=\"noreferrer noopener\" href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2024.10.15.618439v2.full\" target=\"_blank\"><em>preprint<\/em> recent <\/a>que els elements que allibera el <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/sincronitzant-els-parasits-de-la-malaria\/\" target=\"_blank\">par\u00e0sit de la mal\u00e0ria <\/a>quan abandona una c\u00e8l\u00b7lula hoste per anar a una altra s\u00f3n capa\u00e7os d<strong>\u2019induir processos d\u2019inflamaci\u00f3<\/strong>, alterar la morfologia de les unions endotelials i <strong>augmentar la permeabilitat de la barrera.<\/strong> Sobre la base d\u2019aquests resultats, suggereixen possibles vies per a ter\u00e0pies complement\u00e0ries.<\/p>\n\n\n\n<div style=\"height:47px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>La mal\u00e0ria cerebral, quan la infecci\u00f3 per Plasmodium falciparum aconsegueix travessar la barrera hematoencef\u00e0lica (BBB) i arribar al cervell, \u00e9s una complicaci\u00f3 greu d&#8217;aquesta malaltia tropical i t\u00e9 altes taxes de mortalitat, fins i tot despr\u00e9s del tractament amb antipal\u00fadics efectius. Els models experimentals actuals per tractar d\u2019estudiar aquesta etapa de la mal\u00e0ria s\u00f3n limitats. [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":49050,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[279,958,323],"new-type":[40],"class_list":["post-49049","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-embl-barcelona-ca","tag-malaria-ca","tag-microscopia","new-type-foto-de-la-setmana"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/49049","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=49049"}],"version-history":[{"count":10,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/49049\/revisions"}],"predecessor-version":[{"id":49197,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/49049\/revisions\/49197"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/49050"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=49049"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=49049"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=49049"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=49049"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}