{"id":48915,"date":"2025-07-14T10:57:02","date_gmt":"2025-07-14T08:57:02","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=48915"},"modified":"2025-07-14T11:46:39","modified_gmt":"2025-07-14T09:46:39","slug":"una-nova-diana-per-evitar-la-metastasi-abans-que-es-manifesti","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/una-nova-diana-per-evitar-la-metastasi-abans-que-es-manifesti\/","title":{"rendered":"Una nova diana per evitar la met\u00e0stasi abans que es manifesti"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Aturar la met\u00e0stasi abans que s\u2019inici\u00ef<\/strong>. Aquest \u00e9s l\u2019horitz\u00f3 ideal per acabar amb les <a href=\"https:\/\/ellipse.prbb.org\/ca\/toni-celia-terrassa-imim-mes-del-90-de-les-morts-per-cancer-son-degudes-a-una-metastasi\/\">met\u00e0stasis, causants de m\u00e9s del 90% de les morts per c\u00e0ncer<\/a>. Ara, <a rel=\"noreferrer noopener\" href=\"https:\/\/www.imim.cat\/noticies\/1361\/identifiquen-les-llavors-de-la-metastasi-una-nova-diana-per-evitar-la-metastasi-en-cancer-de-mama-abans-que-es-manifesti\" target=\"_blank\">un nou estudi <\/a> liderat des de l&#8217;<a rel=\"noreferrer noopener\" href=\"http:\/\/www.imim.es\/\" target=\"_blank\">Hospital del Mar Research Institute<\/a> ha trobat el qu\u00e8 podria ser un element clau per aconseguir-ho.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Els equips investigadors, liderats per <strong><a href=\"https:\/\/ellipse.prbb.org\/ca\/toni-celia-terrassa-imim-mes-del-90-de-les-morts-per-cancer-son-degudes-a-una-metastasi\/\" target=\"_blank\" rel=\"noreferrer noopener\">Toni Celi\u00e0-Terrassa <\/a><\/strong>al HMRI, han identificat el paper que juga <strong>la prote\u00efna TIM-3<\/strong> en les <strong>c\u00e8l\u00b7lules m\u00e9s agressives iniciadores de met\u00e0stasi<\/strong>, les \u201cllavors\u201d de la met\u00e0stasi. Aquestes s\u00f3n les c\u00e8l\u00b7lules que marxen del tumor primari per expandir-se a d\u2019altres \u00f2rgans. El moment d\u2019instal\u00b7lar-se al seu nou territori, quan encara s\u00f3n molt poques c\u00e8l\u00b7lules, \u00e9s el m\u00e9s cr\u00edtic; per aix\u00f2 atacar a les c\u00e8l\u00b7lules en aquest moment seria una gran oportunitat terap\u00e8utica.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Utilitzant un<a href=\"https:\/\/ellipse.prbb.org\/ca\/els-animals-en-la-recerca-biomedica\/\" target=\"_blank\" rel=\"noreferrer noopener\"> <strong>model de ratol\u00ed<\/strong><\/a>, els i les cient\u00edfiques han demostrat que TIM3 permet a les c\u00e8l\u00b7lules tumorals <strong>suprimir el sistema immunitari quan arriben als \u00f2rgans distants<\/strong> i aix\u00ed assegurar la seva superviv\u00e8ncia. L\u2019estudi s\u2019ha fet amb <strong>c\u00e8l\u00b7lules de <\/strong><a href=\"https:\/\/ellipse.prbb.org\/ca\/un-model-per-a-predir-el-risc-individual-de-cancer-de-mama\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>c\u00e0ncer de mama<\/strong> <\/a>amb met\u00e0stasi al fetge.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Els resultats de l\u2019estudi amb ratolins semblen compatibles amb el qu\u00e8 han trobat en mostres d\u2019una cohort de pacients de l\u2019Hospital del Mar. \u201cEls que tenien <strong>tumors amb nivells alts de TIM-3 presentaven m\u00e9s risc de met\u00e0stasi i de mal pron\u00f2stic<\/strong>\u201d, apunta la <strong>Catalina Rozal\u00e9n<\/strong>, investigadora predoctoral i primera autora de l\u2019article.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ja existeixen f\u00e0rmacs que bloquegen l\u2019acci\u00f3 de TIM-3, i potencialment es podrien utilitzar en pacients d\u2019alt risc (amb alts nivells de TIM-3), per evitar l\u2019aparici\u00f3 de nous tumors. Per\u00f2 \u201c<strong>encara falta molta recerca en <a href=\"https:\/\/ellipse.prbb.org\/ca\/iris-lioba-matilla-vaz-imim-sense-assaigs-clinics-la-medicina-no-podria-avancar\/\" target=\"_blank\" rel=\"noreferrer noopener\">assajos cl\u00ednics<\/a><\/strong> amb el disseny apropiat per arribar a aquest punt\u201d, emfatitza <strong><a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/joan-albanell-de-cancer-de-mama-no-nhi-ha-nomes-un\/\" target=\"_blank\">Joan Albanell<\/a>,<\/strong> tamb\u00e9 autor de l\u2019estudi.<\/p>\n\n\n\n<div style=\"height:51px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un estudi liderat des de l&#8217;Hospital del Mar Research Institute  ha identificat el paper de la prote\u00efna TIM-3 durant l&#8217;inici de la met\u00e0stasi.<\/p>\n","protected":false},"author":6,"featured_media":48918,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[312,497,213,215,205,221],"new-type":[35],"class_list":["post-48915","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-cancer-ca","tag-cancer-de-mama","tag-imim","tag-metastasis-ca","tag-organismes-model","tag-ratoli","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/48915","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=48915"}],"version-history":[{"count":8,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/48915\/revisions"}],"predecessor-version":[{"id":48943,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/48915\/revisions\/48943"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/48918"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=48915"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=48915"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=48915"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=48915"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}