{"id":47450,"date":"2025-04-11T08:20:11","date_gmt":"2025-04-11T06:20:11","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=47450"},"modified":"2025-04-11T08:20:10","modified_gmt":"2025-04-11T06:20:10","slug":"la-relacio-de-la-immunoglobulina-a-amb-la-microbiota-potencia-les-vacunes-de-la-pneumonia","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/la-relacio-de-la-immunoglobulina-a-amb-la-microbiota-potencia-les-vacunes-de-la-pneumonia\/","title":{"rendered":"La relaci\u00f3 de la immunoglobulina A amb la microbiota potencia les vacunes de la pneum\u00f2nia"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.imim.cat\/noticies\/1330\/mostren-la-relacio-entre-la-microbiota-intestinal-la-immunoglobulina-a-i-leficacia-de-les-vacunes\" target=\"_blank\" rel=\"noreferrer noopener\">Un estudi<\/a> liderat per <a href=\"https:\/\/ellipse.prbb.org\/ca\/el-club-del-microbioma-i-el-sistema-immunitari\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Andrea Cerutti<\/strong><\/a> (<a href=\"http:\/\/www.imim.es\/\" target=\"_blank\" rel=\"noreferrer noopener\">Hospital del Mar Research Institute<\/a>) ha trobat que <strong>la immunoglobulina A de l\u2019intest\u00ed potencia la resposta del cos contra les vacunes de <\/strong><a href=\"https:\/\/ellipse.prbb.org\/ca\/la-nebulitzacio-una-manera-mes-segura-dadministrar-antibiotics-per-a-la-pneumonia\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>la pneum\u00f2nia<\/strong><\/a>. L\u2019estudi s\u2019ha fet en col\u00b7laboraci\u00f3 amb l\u2019Institut d\u2019Investigacions Biom\u00e8diques Sant Pau (IIB-Sant Pau), l\u2019Hospital Vall d\u2019Hebron, la Universitat Weill Cornell i l\u2019Hospital Mont Sinai de Nova York i la Universitat de Boston.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">La investigaci\u00f3, portada a terme en ratolins i \u00e9ssers humans, ha vist que aquells ratolins que tenien una defici\u00e8ncia d\u2019immunoglobulina A no responien a <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/avaluant-leficacia-i-lacceptacio-de-la-vacuna-contra-la-covid-19\/\" target=\"_blank\">les vacunes<\/a> contra el pneumococ o ho feien de manera pobre. Aquestes vacunes no estan directament relacionades amb la immunoglobulina, sin\u00f3 que <strong>activen la resposta de la immunoglobulina G<\/strong> que genera els anticossos corresponents. No obstant aix\u00f2, aquest estudi posa de manifest que la immunoglobulina A \u00e9s necess\u00e0ria perqu\u00e8 la vacuna sigui totalment efica\u00e7.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Aix\u00f2 \u00e9s consistent amb el fet que en humans, la defici\u00e8ncia en immunoglobulina A comporta una resposta m\u00e9s ineficient no nom\u00e9s contra la vacuna del pneumococ, sin\u00f3 tamb\u00e9 la del t\u00e8tanus o la dift\u00e8ria.<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>La defici\u00e8ncia d\u2019immunoglobulina A afecta a 1 de cada 160 persones a Espanya.<\/p><\/blockquote>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">La hip\u00f2tesi amb la que treballen els investigadors i investigadores \u00e9s que la defici\u00e8ncia de la immunoglobulina A fa que <a href=\"https:\/\/ellipse.prbb.org\/ca\/la-microbiota-dels-nounats-mes-enlla-de-la-mare\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>la microbiota intestinal<\/strong><\/a><strong> estigui desregulada<\/strong>. Com a conseq\u00fc\u00e8ncia, el sistema immunitari es veu sobrestimulat i no pot generar <a href=\"https:\/\/ellipse.prbb.org\/ca\/el-sistema-immunitari-la-nostra-defensa-contra-els-agents-infecciosos\/\" target=\"_blank\" rel=\"noreferrer noopener\">els anticossos<\/a> contra la pneum\u00f2nia.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A m\u00e9s, la investigaci\u00f3 suggereix que <strong>tractar la defici\u00e8ncia d\u2019immunoglobulina A amb dosis d\u2019aquest antic\u00f2s <\/strong>de manera oral pot estimular la resposta del cos contra la vacuna. Tamb\u00e9, recomanen el tractament a una edat primerenca, ja que podria ser menys efica\u00e7 despr\u00e9s.<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>Sembla que els efectes de la defici\u00e8ncia d\u2019immunoglobulina A al sistema immunitari comencen al poc de n\u00e9ixer. Llavors, s\u2019hauria de comen\u00e7ar la ter\u00e0pia en nens perqu\u00e8 fos efectiva.<\/p><p><strong>Andrea Cerutti <\/strong>(Hospital del Mar Research Institute)<\/p><\/blockquote>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">La relaci\u00f3 de la microbiota amb la immunoglobulina G ja s\u2019havia observat anteriorment. En canvi, fins ara <strong>no s\u2019havia associat la triada immunoglobulina A-microbiota-immunoglobulina G<\/strong>. \u201cSabent que una bona resposta de la immunoglobulina G a les vacunes depenia d\u2019una <a href=\"https:\/\/ellipse.prbb.org\/ca\/la-microbiota-intestinal-un-escut-contra-els-efectes-de-lalcohol\/\" target=\"_blank\" rel=\"noreferrer noopener\">microbiota intestinal<\/a> sana, vam pensar que la immunoglobulina A, que cobreix el 30% dels bacteris de l\u2019intest\u00ed, podia jugar un paper important en aquest ecosistema. La immunoglobulina A <strong>maximitza la diversitat de la microbiota <\/strong>i promou funcions immunometab\u00f2liques beneficioses,\u201d explica Andrea Cerutti.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">L\u2019equip investigador recomana, a partir d\u2019ara, incloure l\u2019efecte de la immunoglobulina A als estudis sobre la relaci\u00f3 entre la microbiota intestinal i la resposta immunit\u00e0ria per l\u2019enlla\u00e7 funcional clar trobat entre les dues immunoglobulines.<\/p>\n\n\n\n<div style=\"height:70px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un equip de l\u2019Hospital del Mar Research Institute descobreix que la defici\u00e8ncia d\u2019immunoglobulina A limita l\u2019efecte de la vacuna de pneumococ a trav\u00e9s del seu impacte sobre la microbiota de l&#8217;intest\u00ed.<\/p>\n","protected":false},"author":34,"featured_media":47444,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[213,411,679,470,415],"new-type":[35],"class_list":["post-47450","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-imim","tag-immunologia","tag-infeccio","tag-microbioma","tag-vacunes","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/47450","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/34"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=47450"}],"version-history":[{"count":4,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/47450\/revisions"}],"predecessor-version":[{"id":47462,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/47450\/revisions\/47462"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/47444"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=47450"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=47450"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=47450"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=47450"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}