{"id":47299,"date":"2025-03-31T09:19:27","date_gmt":"2025-03-31T07:19:27","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=47299"},"modified":"2025-03-31T09:19:20","modified_gmt":"2025-03-31T07:19:20","slug":"inhibeix-i-venceras-el-pas-a-ladultesa-de-la-mosca-drosophila","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/inhibeix-i-venceras-el-pas-a-ladultesa-de-la-mosca-drosophila\/","title":{"rendered":"Inhibeix i vencer\u00e0s: el pas a l\u2019adultesa de la mosca Drosophila"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Un grup d\u2019investigadors i investigadores de <a rel=\"noreferrer noopener\" href=\"https:\/\/www.ibe.upf-csic.es\/\" target=\"_blank\">l\u2019Institut de Biologia Evolutiva (IBE: CSIC-UPF)<\/a> ha determinat que <strong>el pas de la fase de pupa a l\u2019adultesa <\/strong>de la <strong>mosca de la fruita<\/strong> comen\u00e7a quan <strong>el gen <em>E93<\/em> reprimeix el gen <em>Broad<\/em><\/strong>, <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/hem-redefinit-el-proces-de-la-metamorfosi\/\" target=\"_blank\">encarregat del desenvolupament de la pupa<\/a>. Estudis anteriors havien concl\u00f2s que el gen<em> E93<\/em> activava els processos de desenvolupament de la mosca (<a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/de-mosques-i-humans\/\" target=\"_blank\"><em>Drosophila melanogaster<\/em><\/a>) a la seva fase adulta. No obstant aix\u00f2, <a rel=\"noreferrer noopener\" href=\"https:\/\/www.ibe.upf-csic.es\/home\/-\/asset_publisher\/T2caeLMECPvW\/content\/discovery-of-the-genetic-mechanism-that-regulates-the-transition-from-adolescence-to-adulthood-in-insects\/maximized\" target=\"_blank\">en aquest estudi<\/a>, en el que han participat tamb\u00e9 investigadors del <a rel=\"noreferrer noopener\" href=\"http:\/\/www.crg.eu\/\" target=\"_blank\">Centre de Regulaci\u00f3 Gen\u00f2mica (CRG)<\/a>, s\u2019ha vist que l\u2019expressi\u00f3 del gen <em>Broad<\/em> bloqueja el desenvolupament adult. Una vegada el gen <em>E93<\/em> inhibeix el gen <em>Broad<\/em>, la mosca arriba a l\u2019adultesa.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">L\u2019estudi analitza a nivell g\u00e8nic <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/lexpert-en-metamorfosi-dels-insectes-xavier-belles-publica-un-nou-llibre\/\" target=\"_blank\">la metamorfosi de la mosca<\/a> i la relaci\u00f3 dels tres gens principals en aquest proc\u00e9s, <em>Chinmo<\/em>, <em>Broad<\/em> i <em>E93<\/em>. El primer \u00e9s l\u2019encarregat del desenvolupament durant la fase larva, l\u2019etapa juvenil de la mosca, mentre que els altres dos s\u2019associen amb les etapes de pupa i adultesa respectivament. Aix\u00ed, ha determinat que el gen <em>Broad<\/em> tamb\u00e9 evita que els processos de la fase pupa comencin abans de temps, \u00e9s a dir, a l\u2019etapa larva. <strong><a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/josefa-cruz-ibe-avui-dia-sense-la-passio-no-et-dediques-a-la-ciencia\/\" target=\"_blank\">Josefa Cruz<\/a><\/strong> primera autora de l\u2019article diu que \u201c<strong>el gen <em>Broad<\/em> seria un gen \u201cPeter Pan\u201d <\/strong>que mant\u00e9 a l\u2019insecte en una fase interm\u00e8dia entre la juvenil i l\u2019adulta, donant temps perqu\u00e8 els \u00f2rgans es desenvolupin correctament abans de la transici\u00f3 a l\u2019adultesa\u201d.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">L\u2019estudi dels <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/reconstruint-lexpressio-genica-durant-el-desenvolupament\/\" target=\"_blank\">mecanismes d\u2019activaci\u00f3 i inhibici\u00f3 d\u2019aquests gens<\/a> pot ser <strong>clau per entendre el desenvolupament del c\u00e0ncer en alguns casos<\/strong>. Els gens hom\u00f2legs a <em>Broad<\/em>, <em>E93<\/em> i <em>Chinmo<\/em> als humans tenen un paper fonamental als processos cancer\u00edgens. El gen de l\u2019etapa juvenil s\u2019encarrega d\u2019afavorir el creixement dels teixits. En canvi, els de les etapes posteriors funcionen en humans com supressors tumorals, limitant la proliferaci\u00f3 descontrolada i afavorint la maduraci\u00f3 cel\u00b7lular. Comprendre la relaci\u00f3 entre ells <strong>pot obrir portes a noves ter\u00e0pies oncol\u00f2giques<\/strong> basades en els processos de divisi\u00f3 i diferenciaci\u00f3 cel\u00b7lular, aix\u00ed com oferir noves perspectives sobre l\u2019evoluci\u00f3 humana.<\/p>\n\n\n\n<div style=\"height:59px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Un nou estudi realitzat a l\u2019IBE:CSIC-UPF dilucida el mecanisme g\u00e8nic de la metamorfosi de la mosca de la fruita.<\/p>\n","protected":false},"author":34,"featured_media":47292,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[312,338,283,332,211],"new-type":[35],"class_list":["post-47299","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-cancer-ca","tag-drosophila","tag-evolucio","tag-gens","tag-ibe-csic-upf","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/47299","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/34"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=47299"}],"version-history":[{"count":5,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/47299\/revisions"}],"predecessor-version":[{"id":47360,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/47299\/revisions\/47360"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/47292"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=47299"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=47299"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=47299"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=47299"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}