{"id":47228,"date":"2025-03-24T12:34:32","date_gmt":"2025-03-24T11:34:32","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=47228"},"modified":"2025-03-24T12:19:41","modified_gmt":"2025-03-24T11:19:41","slug":"la-formacio-del-fus-mitotic-depen-nomes-de-dues-proteines","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/la-formacio-del-fus-mitotic-depen-nomes-de-dues-proteines\/","title":{"rendered":"La formaci\u00f3 del fus mit\u00f2tic dep\u00e8n nom\u00e9s de dues prote\u00efnes"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Investigadors i investigadores del <a rel=\"noreferrer noopener\" href=\"http:\/\/www.crg.eu\/\" target=\"_blank\">Centre de Regulaci\u00f3 Gen\u00f2mica (CRG)<\/a> i la Universitat de Cambridge han descobert que nom\u00e9s <strong>la kinesina-5 i la dine\u00efna<\/strong>, dues prote\u00efnes motores, <strong>s\u00f3n imprescindibles per a formar un fus mit\u00f2tic funcional<\/strong>. Els altres factors involucrats nom\u00e9s estabilitzarien i refinarien el sistema.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">El fus mit\u00f2tic, format per unes varetes anomenades <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/entenent-la-formacio-i-creixement-dels-microtubuls\/\" target=\"_blank\">microt\u00fabuls<\/a>, \u00e9s la m\u00e0quina molecular responsable de la <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/descobert-el-mecanisme-per-a-la-separacio-de-les-cellules-durant-la-divisio-cellular\/\" target=\"_blank\">divisi\u00f3 cel\u00b7lular<\/a> o mitosis. Tot i que est\u00e0 amplament representat, el seu nom \u00e9s menys conegut. \u00c9s aquella <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/un-enzim-de-la-divisio-cellular-com-a-possible-diana-terapeutica-contra-el-cancer\/\" target=\"_blank\">estructura de forma ovalada<\/a> que es forma per separar els cromosomes. <strong>El fus mit\u00f2titc \u00e9s el responsable de separar el material gen\u00e8tic <\/strong>equitativament entre els dos pols per a formar les c\u00e8l\u00b7lules filles.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a rel=\"noreferrer noopener\" href=\"https:\/\/www.crg.eu\/en\/news\/cell-division-follows-rules-active-matter#2\" target=\"_blank\">L\u2019estudi<\/a> s\u2019ha dut a terme a trav\u00e9s de <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/lestructura-proteica-clau-en-levolucio-i-la-salut\/\" target=\"_blank\">simulacions computacionals<\/a> fent servir la plataforma Cytosim de <strong>Fran\u00e7ois N\u00e9d\u00e9lec<\/strong>, coautor principal de l\u2019article a Cambridge. Aquest <em>software<\/em> simula el comportament mec\u00e0nic i qu\u00edmic dels microt\u00fabuls i les prote\u00efnes associades. \u201cExplorar m\u00faltiples dissenys i propietats de prote\u00efnes en simulacions ens ajuda a entendre per qu\u00e8 aquestes prote\u00efnes han evolucionat fins la forma actual\u201d, explica <strong>Wei-Xiang Chew<\/strong>, investigador postdoctoral al grup de <strong><a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/la-vida-en-un-portaobjectes\/\" target=\"_blank\">Thomas Surrey del CRG<\/a><\/strong> i primer autor de l\u2019estudi.<\/p>\n\n\n\n<div style=\"height:41px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u00ab\u00c9s extraordinari com n&#8217;\u00e9s de senzill construir la forma b\u00e0sica d&#8217;un fus\u00bb<\/p><p><strong>Thomas Surrey<\/strong> (CRG), coautor principal de l&#8217;article i Professor d&#8217;Investigaci\u00f3 ICREA<\/p><\/blockquote>\n\n\n\n<div style=\"height:41px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Aquesta an\u00e0lisi podria ajudar a entendre <strong>malalties provocades per divisions cel\u00b7lulars irregulars<\/strong>, com \u00e9s el c\u00e0ncer. A m\u00e9s, con\u00e8ixer com est\u00e0 format el fus contribuiria a la seva construcci\u00f3 al laboratori, el que faria m\u00e9s f\u00e0cil la recerca dels tractaments de les mateixes malalties.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Equips del CRG i Cambridge han determinat que nom\u00e9s la kinesina-5 i la dine\u00efna s\u00f3n necessaris per impulsar l&#8217;autoorganitzaci\u00f3 dels microt\u00fabuls en un fus bipolar funcional que pugui separar l&#8217;ADN.<\/p>\n","protected":false},"author":34,"featured_media":47225,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[261,312,265,271,219,329],"new-type":[35],"class_list":["post-47228","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-bioinformatica","tag-cancer-ca","tag-crg-ca","tag-divisio-cellular","tag-microtubuls","tag-proteines","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/47228","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/34"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=47228"}],"version-history":[{"count":6,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/47228\/revisions"}],"predecessor-version":[{"id":47272,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/47228\/revisions\/47272"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/47225"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=47228"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=47228"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=47228"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=47228"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}