{"id":47179,"date":"2025-03-20T08:46:27","date_gmt":"2025-03-20T07:46:27","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=47179"},"modified":"2025-03-20T08:46:00","modified_gmt":"2025-03-20T07:46:00","slug":"dades-massives-per-a-predir-la-resposta-a-la-immunoterapia","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/dades-massives-per-a-predir-la-resposta-a-la-immunoterapia\/","title":{"rendered":"Dades massives per a predir la resposta a la immunoter\u00e0pia"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Nom\u00e9s un 20% dels pacients de c\u00e0ncer de bufeta responen al tractament d\u2019immunoter\u00e0pia. Ara, equips d\u2019investigadores al PRBB han utilitzat <strong><a href=\"https:\/\/www.imim.es\/noticies\/1324\/lanalisi-massiva-de-dades-permet-avancar-en-la-comprensio-de-com-funciona-la-immunoterapia\" target=\"_blank\" rel=\"noreferrer noopener\">l\u2019an\u00e0lisi massiva de dades per a identificar marcadors clau del c\u00e0ncer de bufeta<\/a> que podran ajudar a determinar el nivell de resposta a la immunoter\u00e0pia<\/strong>. L\u2019equip, coordinat per <strong><a href=\"https:\/\/ellipse.prbb.org\/ca\/mar-alba-nova-directora-del-grib-rep-una-erc-de-25-milions-deuros\/\" target=\"_blank\" rel=\"noreferrer noopener\">Mar Alb\u00e0<\/a> <\/strong>(codirectora del Programa de <a href=\"https:\/\/grib.upf.edu\/\" target=\"_blank\" rel=\"noreferrer noopener\">Recerca en Inform\u00e0tica Biom\u00e8dica (GRIB)<\/a>), <strong>J\u00falia Perera<\/strong> y <strong>Joaquim Bellmunt <\/strong>(<a href=\"http:\/\/www.imim.es\/\" target=\"_blank\" rel=\"noreferrer noopener\">Hospital del Mar Research Institute<\/a>) i en el que ha col\u00b7laborat <strong>Robert Castelo <\/strong>(<a href=\"https:\/\/www.upf.edu\/web\/biomed\/\" target=\"_blank\" rel=\"noreferrer noopener\">Departament de Medicina i Ci\u00e8ncies de la Vida, MELIS-UPF<\/a>), ha analitzat les dades de <strong>m\u00e9s de 700 pacients amb c\u00e0ncer de bufeta <\/strong>de sis cohorts diferents.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Les investigadores i els investigadors han desenvolupat <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/noves-eines-i-algoritmes-dia-per-detectar-millor-el-cancer-les-malalties-genetiques-i-les-infeccions-viriques\/\" target=\"_blank\">un algoritme d\u2019aprenentatge autom\u00e0tic<\/a> per veure com <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/que-es-la-immunoterapia\/\" target=\"_blank\">respon el pacient a la immunoter\u00e0pia<\/a> segons el subtipus de c\u00e0ncer de bufeta. Amb ell, han descobert que <strong>el subtipus neuronal<\/strong>, tot i ser el menys com\u00fa dels cinc subtipus, <strong>\u00e9s el que millor respon al tractament<\/strong>. Gr\u00e0cies a l\u2019algoritme, han detectat que els marcadors que millor determinen l\u2019\u00e8xit del tractament s\u00f3n el n\u00famero de mutacions introdu\u00efdes per la fam\u00edlia d\u2019enzims APOBEC, el n\u00famero de mutacions del tumor i la quantitat de macr\u00f2fags antiinflamatoris. Tamb\u00e9 han identificat alguns marcadors al <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/miro-una-nova-mirada-als-models-tumorals\/\" target=\"_blank\">microambient tumoral<\/a> i, gr\u00e0cies al gran n\u00famero de pacients, han detectat noves mutacions rares que farien que el tumor fos invisible al sistema immunitari.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u00ab\u00c9s important entendre els mecanismes de resposta dins dels diferents subgrups, perqu\u00e8 hi ha una gran heterogene\u00eftat tumoral\u00bb<\/p><p><strong>Lilian Marie Boll<\/strong>, primera autora de l&#8217;article<\/p><\/blockquote>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Aquest estudi ajuda a analitzar els mecanismes de resposta dels diferents subtipus de c\u00e0ncer de bufeta davant la immunoter\u00e0pia. A m\u00e9s, <strong>destaca la gran diversitat que hi ha <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/microproteines-per-generar-vacunes-contra-el-cancer\/\" target=\"_blank\">als tumors<\/a><\/strong>, el que complica el seu tractament. L\u2019equip investigador ressalta <strong>la necessitat de tenir una gran quantitat de dades<\/strong> per a poder desenvolupar models predictius que permetin tractar els tumors individualment.<\/p>\n\n\n\n<div style=\"height:56px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>L\u2019estudi, realitzat \u00edntegrament dins del programa de Recerca en Inform\u00e0tica Biom\u00e8dica (GRIB) de l\u2019Hospital del Mar Research Institute i del Departament de Medicina i Ci\u00e8ncies de la Vida (MELIS-UPF), s\u2019ha enfocat al c\u00e0ncer de bufeta.<\/p>\n","protected":false},"author":34,"featured_media":47169,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[261,761,312,500,213,273],"new-type":[35],"class_list":["post-47179","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-bioinformatica","tag-biomarcadors","tag-cancer-ca","tag-cancer-de-bufeta","tag-imim","tag-melis-upf-ca","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/47179","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/34"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=47179"}],"version-history":[{"count":4,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/47179\/revisions"}],"predecessor-version":[{"id":47202,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/47179\/revisions\/47202"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/47169"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=47179"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=47179"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=47179"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=47179"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}