{"id":47131,"date":"2025-03-18T13:16:15","date_gmt":"2025-03-18T12:16:15","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=47131"},"modified":"2025-03-18T13:16:08","modified_gmt":"2025-03-18T12:16:08","slug":"reconstruint-lexpressio-genica-durant-el-desenvolupament","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/reconstruint-lexpressio-genica-durant-el-desenvolupament\/","title":{"rendered":"Reconstruint l&#8217;expressi\u00f3 g\u00e8nica durant el desenvolupament"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Un dels principals desafiaments en la <strong>biologia del desenvolupament<\/strong> \u00e9s la dificultat d&#8217;observar el <strong><a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/tag\/desenvolupament\/\" target=\"_blank\">desenvolupament embrionari<\/a> en temps real<\/strong>, especialment en mam\u00edfers, on la formaci\u00f3 d&#8217;\u00f2rgans s&#8217;esdev\u00e9 dins l&#8217;\u00fater. Per tant, els <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/tag\/embrio\/\" target=\"_blank\">embrions <\/a>s&#8217;estudien a trav\u00e9s d&#8217;instant\u00e0nies est\u00e0tiques en diferents etapes, la qual cosa proporciona una visi\u00f3 fragmentada i requereix una gran quantitat de mostres.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">El desafiament es torna encara m\u00e9s gran quan s&#8217;estudien<strong> els patrons d&#8217;expressi\u00f3 g\u00e8nica<\/strong>, ja que aquests no estan vinculats a estructures anat\u00f2miques fixes, la qual cosa complica encara m\u00e9s la interpretaci\u00f3 de les dades.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Per superar aquestes limitacions, cient\u00edfics i cient\u00edfiques del grup de <strong><a href=\"https:\/\/ellipse.prbb.org\/ca\/james-sharpe-embl-barcelona-donem-un-impuls-a-la-connexio-entre-la-ciencia-local-i-la-resta-deuropa\/\" target=\"_blank\" rel=\"noreferrer noopener\">James Sharpe<\/a><\/strong> al <a rel=\"noreferrer noopener\" href=\"https:\/\/www.embl.es\/\" target=\"_blank\">Laboratori Europeu de Biologia Molecular de Barcelona (EMBL Barcelona)<\/a><strong> han desenvolupat un <\/strong><a rel=\"noreferrer noopener\" href=\"https:\/\/www.embl.org\/news\/science-technology\/how-video-games-inspired-a-new-way-to-visualise-limb-development\/\" target=\"_blank\"><strong>nou m\u00e8tode per reconstruir una l\u00ednia de temps cont\u00ednua dels patrons d&#8217;expressi\u00f3 g\u00e8nica durant el desenvolupament de les extremitats dels ratolins.<\/strong><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Per aix\u00f2 van fer una <strong>estimaci\u00f3 de les dades d&#8217;expressi\u00f3 g\u00e8nica<\/strong> en els intervals entre els mesuraments reals. Van fer aquesta interpolaci\u00f3 <strong>per a segments de teixit individuals <\/strong>abans d&#8217;acoblar-los en una representaci\u00f3 completa. Aix\u00f2 els va permetre capturar la din\u00e0mica general de l&#8217;expressi\u00f3 g\u00e8nica durant el desenvolupament.<\/p>\n\n\n\n<div style=\"height:43px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p><em>Aquest m\u00e8tode permet visualitzar els canvis en l&#8217;expressi\u00f3 g\u00e8nica de forma din\u00e0mica, sense necessitat de recopilar dades addicionals.<\/em><\/p><\/blockquote>\n\n\n\n<div style=\"height:43px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Un aven\u00e7 clau va provenint d&#8217;una font inesperada: <strong>els videojocs<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Mentre jugava a un videojoc, l&#8217;estudiant de doctorat <strong>Laura Avi\u00f1\u00f3-Esteban <\/strong>es va fixar que els desenvolupadors de jocs utilitzaven interpolacions suaus per\u00f2 flexibles per als moviments de c\u00e0mera i les animacions. Les seves indagacions van portar el laboratori a adoptar aquestes funcions matem\u00e0tiques comunament utilitzades en els gr\u00e0fics per ordinador (anomenades B-Splines) per fer les reconstruccions de l&#8217;expressi\u00f3 g\u00e8nica.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">El m\u00e8tode es va aplicar amb \u00e8xit a <strong>Sox9<\/strong>, un gen implicat en el desenvolupament de l&#8217;esquelet, aix\u00ed com a altres processos com la <strong>formaci\u00f3 del tub neural<\/strong>, la qual cosa demostra la seva \u00e0mplia aplicabilitat.<\/p>\n\n\n\n<div style=\"height:48px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Utilitzant les matem\u00e0tiques dels desenvolupadors de videojocs, un equip investigador de l&#8217;EMBL Barcelona ha desenvolupat un m\u00e8tode per visualitzar els canvis en l&#8217;expressi\u00f3 g\u00e8nica de forma din\u00e0mica, mitjan\u00e7ant la interpolaci\u00f3 de dades.<\/p>\n","protected":false},"author":6,"featured_media":47095,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[277,279,686],"new-type":[35],"class_list":["post-47131","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-desenvolupament","tag-embl-barcelona-ca","tag-embrio","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/47131","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=47131"}],"version-history":[{"count":3,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/47131\/revisions"}],"predecessor-version":[{"id":47134,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/47131\/revisions\/47134"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/47095"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=47131"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=47131"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=47131"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=47131"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}