{"id":46867,"date":"2025-03-07T09:36:27","date_gmt":"2025-03-07T08:36:27","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=46867"},"modified":"2025-03-12T12:51:49","modified_gmt":"2025-03-12T11:51:49","slug":"miro-una-nova-mirada-als-models-tumorals","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/miro-una-nova-mirada-als-models-tumorals\/","title":{"rendered":"MIRO, una nova mirada als models tumorals"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Dos equips de l&#8217;<a rel=\"noreferrer noopener\" href=\"https:\/\/www.imim.es\/ca_index.html\" target=\"_blank\">Hospital del Mar Research Institute<\/a> i de <a rel=\"noreferrer noopener\" href=\"https:\/\/ibecbarcelona.eu\/ca\/\" target=\"_blank\">l\u2019Institut de Bioenginyeria de Catalunya (IBEC)<\/a> han desenvolupat <strong>MIRO, una nova plataforma tumoral que permetr\u00e0 personalitzar els tractaments contra el c\u00e0ncer<\/strong>. El nom de MIRO correspon a les sigles <em><u><a rel=\"noreferrer noopener\" href=\"https:\/\/www.imim.es\/noticies\/1321\/desenvolupen-un-dispositiu-que-replica-els-tumors-per-estudiar-leficacia-de-tractaments-amb-immunoterapia\" target=\"_blank\">Micro Immune Response On-chip<\/a><\/u><\/em>. \u00c9s un petit dispositiu microflu\u00eddic on es fan cr\u00e9ixer les c\u00e8l\u00b7lules tumorals humanes i les del seu entorn, anomenades <strong>microambient<\/strong>, per a veure com interaccionen. A difer\u00e8ncia d\u2019altres models microflu\u00eddics que no aconsegueixen captar <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/tumicc-mes-enlla-de-les-cellules-tumorals\/\" target=\"_blank\">la relaci\u00f3 de les c\u00e8l\u00b7lules canceroses amb el microambient<\/a>, <strong>aquest chip reprodueix l\u2019estructura tridimensional del tumor i el seu entorn <\/strong>per a entendre millor com <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/nous-avencos-pel-tractament-del-cancer-de-pell-colon-i-recte\/\" target=\"_blank\">es desenvolupa i lluita un tumor<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Amb aquest nou model, s\u2019ha pogut veure el mecanisme <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/pot-el-nostre-sistema-immunitari-eliminar-cel%c2%b7lules-tumorals\/\" target=\"_blank\">d\u2019acci\u00f3 de la immunoter\u00e0pia<\/a>. Aquest tractament \u00e9s efectiu en nom\u00e9s d\u2019un 20 a un 40% dels pacients. Gr\u00e0cies a aquest model, s\u2019ha vist <strong>que el microambient crea una barrera f\u00edsica que envolta el tumor<\/strong> i que impedeix que els anticossos penetrin en la majoria dels casos. Els estudis s\u2019han dut a terme <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/potencial-via-per-evitar-la-resistencia-al-tractament-dun-dels-cancers-de-mama-mes-agressius\/\" target=\"_blank\">en el c\u00e0ncer de mama HER2+<\/a>, per\u00f2 ja s\u2019est\u00e0 estudiant tant en <strong>el de colon com en el de pulm\u00f3<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Segons <strong>Alexandre Calon<\/strong>, responsable del projecte a l\u2019Hospital del Mar Research Institute, el model \u201ces pot fer servir per a l\u2019estudi d\u2019altres tractaments, no nom\u00e9s<a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/gran-empenta-a-la-immunoterapia-contra-el-cancer-de-mama-mes-agressiu\/\" target=\"_blank\"> immunoter\u00e0pia<\/a>. Permet avaluar, per exemple, els efectes adversos del microambient tumoral sobre altres ter\u00e0pies dirigides a la c\u00e8l\u00b7lula cancerosa. El sistema est\u00e0 dissenyat per a <strong>obtenir informacions sobre la immunitat antitumoral en 4 dies de cocultiu<\/strong>\u201d. Aquest model permetria identificar aviat el tractament adequat per a cada pacient i \u00e9s un salt en l\u2019aven\u00e7 de la medicina personalitzada.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Els dos centres, junt amb la <a rel=\"noreferrer noopener\" href=\"https:\/\/www.icrea.cat\/ca\/\" target=\"_blank\">Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA)<\/a>, <strong>han sol\u00b7licitat una patent per la tecnologia<\/strong> MIRO. Amb aix\u00f2, volen que la plataforma arribi el m\u00e9s aviat possible tant a hospitals com a la ind\u00fastria farmac\u00e8utica per a que es pugui fer servir amb els i les pacients.<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un xip que reprodueix l&#8217;estructura tridimensional del tumor i el seu entorn,, desenvolupat a l&#8217;Hospital del Mar Research Institute i l\u2019IBEC, obre una nova porta a la medicina personalitzada.<\/p>\n","protected":false},"author":34,"featured_media":46996,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[559,312,213,757],"new-type":[35],"class_list":["post-46867","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-bioenginyeria","tag-cancer-ca","tag-imim","tag-tractament","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/46867","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/34"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=46867"}],"version-history":[{"count":5,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/46867\/revisions"}],"predecessor-version":[{"id":46877,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/46867\/revisions\/46877"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/46996"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=46867"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=46867"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=46867"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=46867"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}