{"id":46759,"date":"2025-03-03T09:46:34","date_gmt":"2025-03-03T08:46:34","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=46759"},"modified":"2025-03-31T12:56:28","modified_gmt":"2025-03-31T10:56:28","slug":"domesticar-bacteris-pot-ajudar-a-tractar-malalties-de-la-pell","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/domesticar-bacteris-pot-ajudar-a-tractar-malalties-de-la-pell\/","title":{"rendered":"Domesticar bacteris pot ajudar a tractar malalties de la pell"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">L\u2019equip liderat per <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/marc-guell-hem-dexplotar-millor-el-talent-i-excellencia-que-te-barcelona-a-nivell-de-transferencia-de-coneixement\/\" target=\"_blank\">Marc G\u00fcell<\/a> del Departament de Medicina i Ci\u00e8ncies de la Vida (<a rel=\"noreferrer noopener\" href=\"https:\/\/www.upf.edu\/web\/biomed\/\" target=\"_blank\">MELIS<\/a>) de la Universitat Pompeu Fabra <a rel=\"noreferrer noopener\" href=\"https:\/\/www.upf.edu\/web\/focus\/w\/investigadors-upf-bacteri-mes-abundant-pell-afeccions-cutanies\" target=\"_blank\">ha dissenyat un conjunt d\u2019onze eines gen\u00e8tiques per a que el bacteri <em>Cutibacerium acnes <\/em>(<em>C. acnes<\/em>) <strong>secreti compostos terap\u00e8utics<\/strong><\/a>. Com a prova de concepte, el kit s\u2019ha provat perqu\u00e8 <strong>el bacteri produeixi antioxidants responent a l\u2019estr\u00e8s oxidatiu<\/strong> causat per la radiaci\u00f3 ultraviolada &#8211; una de les causes de l\u2019envelliment de la pell i que, en combinaci\u00f3 amb altres factors, pot causar c\u00e0ncer cutani. La investigaci\u00f3 s\u2019ha recollit a la revista <em><a rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1016\/j.cels.2025.101169\" target=\"_blank\">Cell Systems<\/a> <\/em>amb <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/un-jove-investigador-del-melis-upf-guanyador-de-leu-talenton-amb-un-projecte-sobre-cancer\/\" target=\"_blank\">Guillermo Nevot<\/a> i <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/skindev-un-projecte-de-biologia-sintetica-per-a-tractar-la-dermatitis\/\" target=\"_blank\">Javier Santos-Moreno<\/a> com a primers coautors, i podria suposar el primer pas per al desenvolupament d\u2019aplicacions t\u00f2piques.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">El conjunt d\u2019eines cont\u00e9, entre d\u2019altres, un <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/choanoflagellates-friends-una-conferencia-sobre-els-nostres-familiars-unicel%c2%b7lulars-mes-propers\/\" target=\"_blank\">plasmidi<\/a>. Aquesta mol\u00e8cula d\u2019ADN cont\u00e9 tota <strong>la informaci\u00f3 que controla la secreci\u00f3 dels compostos terap\u00e8utics<\/strong> i la seva quantitat segons els est\u00edmuls externs. Tamb\u00e9 cont\u00e9 un mecanisme de control perqu\u00e8 <em>C. acnes <\/em>no generi el seu propi aliment i que, aix\u00ed, nom\u00e9s proliferi quan \u00e9s alimentada externament i en el moment adequat.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">La introducci\u00f3 de <a href=\"https:\/\/ellipse.prbb.org\/ca\/medicina-viva-contra-les-afeccions-pulmonars\/\" target=\"_blank\" rel=\"noreferrer noopener\">bacteris modificats gen\u00e8ticament <\/a>per tractar les afeccions, coneguda com <strong>ter\u00e0pia amb productes bioterap\u00e8utics vius dissenyats<\/strong> (eLBPs per les seves sigles en angl\u00e8s), ja s\u2019havia provat a la pell. Tot i aix\u00ed, mai s\u2019havia fet amb <em>C. acnes<\/em>. Aquest bacteri \u00e9s el m\u00e9s abundant de la pell i, tot i que normalment <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/aliar-se-amb-els-bacteris-de-la-pell-per-tractar-patologies\/\" target=\"_blank\">s\u2019associa amb el desenvolupament de l\u2019acne<\/a>, la pres\u00e8ncia dels filotips II i III \u00e9s s\u00edmbol d\u2019una pell sana. S\u2019ha fet servir <strong><em>C. acnes<\/em> com a producte bioterap\u00e8utic viu perqu\u00e8 el seu genoma \u00e9s molt estable<\/strong> i no interacciona ni es recombina amb altres bacteris. A m\u00e9s, a difer\u00e8ncia d\u2019altres bacteris testats anteriorment, <strong>es pot trasplantar d\u2019un donant a un pacient<\/strong>. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Aquest estudi \u00e9s un primer pas per a poder desenvolupar <strong>cremes terap\u00e8utiques de llarga durada, m\u00e9s segures i assequibles<\/strong> que altres ter\u00e0pies. En un futur, els productes bioterap\u00e8utics vius d\u2019us t\u00f2pic podrien ser una soluci\u00f3 per a afeccions cut\u00e0nies cr\u00f2niques.<\/p>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Investigadors de MELIS-UPF han desenvolupat un conjunt d\u2019eines gen\u00e8tiques que modifiquen el bacteri C. acnes per a combatre els problemes cutanis.<\/p>\n","protected":false},"author":34,"featured_media":46753,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[477,307,273,470],"new-type":[35,43],"class_list":["post-46759","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-bacteris","tag-biologia-sintetica","tag-melis-upf-ca","tag-microbioma","new-type-noticies","new-type-recomanem"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/46759","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/34"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=46759"}],"version-history":[{"count":9,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/46759\/revisions"}],"predecessor-version":[{"id":46793,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/46759\/revisions\/46793"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/46753"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=46759"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=46759"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=46759"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=46759"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}