{"id":45597,"date":"2024-12-11T09:59:37","date_gmt":"2024-12-11T08:59:37","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=45597"},"modified":"2024-12-11T09:59:13","modified_gmt":"2024-12-11T08:59:13","slug":"una-nova-forma-de-lluitar-contra-la-resistencia-als-antibiotics","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/una-nova-forma-de-lluitar-contra-la-resistencia-als-antibiotics\/","title":{"rendered":"Una nova forma de lluitar contra la resist\u00e8ncia als antibi\u00f2tics"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">La <a rel=\"noopener noreferrer\" href=\"https:\/\/ellipse.prbb.org\/ca\/resistencies-microbianes-als-anitibiotics-on-estem\/\" target=\"_blank\"><strong>resist\u00e8ncia als antibi\u00f2tics<\/strong><\/a> \u00e9s un problema urgent de salut global, i l&#8217;equip de<a rel=\"noopener noreferrer\" href=\"https:\/\/ellipse.prbb.org\/ca\/jordi-garcia-ojalvo-dcexs-upf-volem-crear-models-acurats-i-personalitzats-del-cervell-de-cada-pacient\/\" target=\"_blank\"><strong> Jordi Garcia-Ojalvo<\/strong><\/a> al <a rel=\"noopener noreferrer\" href=\"https:\/\/www.upf.edu\/web\/biomed\/\" target=\"_blank\">Departament de Medicina i Ci\u00e8ncies de la Vida (MELIS-UPF)<\/a>, en col\u00b7laboraci\u00f3 amb cient\u00edfics i cient\u00edfiques de la Universitat de Calif\u00f2rnia a San Diego, <a rel=\"noopener noreferrer\" href=\"https:\/\/www.upf.edu\/web\/biomed\/news\/-\/asset_publisher\/CRcETTCV7Uyn\/content\/nova-via-resistencies-antibacterianes-sense-crear-nous-antibiotics\/10193\/maximized\" target=\"_blank\">han descobert una estrat\u00e8gia innovadora<\/a> per abordar-lo.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">L\u2019estudi revela que <strong>limitar la disponibilitat de magnesi (Mg\u00b2\u207a) per a bacteris resistents als antibi\u00f2tics podria dificultar la seva superviv\u00e8ncia<\/strong> i evitar la propagaci\u00f3 de la resist\u00e8ncia sense necessitat de desenvolupar nous antibi\u00f2tics.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">La investigaci\u00f3 se centra en el <strong>ribosoma<\/strong>, un component cr\u00edtic de les c\u00e8l\u00b7lules que \u00e9s objectiu d\u2019antibi\u00f2tics com l\u2019eritromicina. Una <strong>soca mutant de&nbsp;<em>Bacillus subtilis<\/em><\/strong>&nbsp;(L22) t\u00e9 alteracions ribos\u00f2miques que li confereixen resist\u00e8ncia als antibi\u00f2tics. Tanmateix, aquestes mutacions imposen un cost fisiol\u00f2gic: <a rel=\"noopener noreferrer\" href=\"https:\/\/ellipse.prbb.org\/ca\/el-magnesi-afavoreix-la-supervivencia-dels-bacteris-front-a-antibiotics\/\" target=\"_blank\">els <strong>ribosomes mutants acumulen m\u00e9s magnesi<\/strong><\/a>, deixant-ne menys de disponible per a processos essencials com la producci\u00f3 d\u2019ATP, que \u00e9s crucial per a l\u2019energia cel\u00b7lular. Aquest desavantatge es fa m\u00e9s evident quan el magnesi ambiental \u00e9s esc\u00e0s, <strong>restringint la superviv\u00e8ncia de les soques mutants en comparaci\u00f3 amb les no mutades<\/strong>.<\/p>\n\n\n\n<div style=\"height:32px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>Limitar els nivells de magnesi a l\u2019entorn podria ajudar a restringir la propagaci\u00f3 de soques resistents als antibi\u00f2tics.<\/p><\/blockquote>\n\n\n\n<div style=\"height:32px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Mitjan\u00e7ant models computacionals, els investigadors han confirmat la connexi\u00f3 entre la din\u00e0mica del Mg\u00b2\u207a i la capacitat de sobreviure dels bacteris. Els resultats suggereixen que <strong>manipular els nivells de magnesi a l\u2019entorn podria ser una aproximaci\u00f3 innovadora per limitar la propagaci\u00f3 de soques resistents als antibi\u00f2tics<\/strong>, oferint una nova dimensi\u00f3 en <a rel=\"noopener noreferrer\" href=\"https:\/\/ellipse.prbb.org\/ca\/una-base-de-dades-de-genomes-de-bacteris-i-els-seus-hostes-pel-desenvolupament-dantibiotics\/\" target=\"_blank\">la lluita contra la resist\u00e8ncia antimicrobiana<\/a>.<\/p>\n\n\n\n<div style=\"height:56px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Una nova recerca d&#8217;un equip del MELIS-UPF suggereix que dirigir-se a les vulnerabilitats bacterianes, com ara la depend\u00e8ncia de magnesi, podria ser una eina valuosa per combatre la resist\u00e8ncia als antibi\u00f2tics.<\/p>\n","protected":false},"author":6,"featured_media":45573,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[711,477,261,273],"new-type":[35],"class_list":["post-45597","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-antibiotic-ca","tag-bacteris","tag-bioinformatica","tag-melis-upf-ca","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/45597","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=45597"}],"version-history":[{"count":5,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/45597\/revisions"}],"predecessor-version":[{"id":45631,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/45597\/revisions\/45631"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/45573"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=45597"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=45597"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=45597"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=45597"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}