{"id":43841,"date":"2024-07-24T11:07:33","date_gmt":"2024-07-24T09:07:33","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=43841"},"modified":"2024-07-24T11:07:16","modified_gmt":"2024-07-24T09:07:16","slug":"descobreixen-com-es-formen-els-insulinomes-un-tipus-de-tumor-de-les-cellules-beta-del-pancrees-molt-poc-frequent","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/descobreixen-com-es-formen-els-insulinomes-un-tipus-de-tumor-de-les-cellules-beta-del-pancrees-molt-poc-frequent\/","title":{"rendered":"Descobreixen com es formen els insulinomes, un tipus de tumor de les c\u00e8l\u00b7lules beta del p\u00e0ncrees molt poc freq\u00fcent"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Els <strong>insulinomes <\/strong>(o tumor neuroendocr\u00ed de p\u00e0ncrees) s\u00f3n un<strong> tipus rar de tumor neuroendocr\u00ed <\/strong>que afecta les c\u00e8l\u00b7lules beta del p\u00e0ncrees, portant-les a expandir-se i produir insulina en exc\u00e9s. Es diagnostiquen anualment quatre persones de cada mili\u00f3 &#8211; Steve Jobs va ser un d&#8217;ells, donant visibilitat a aquest c\u00e0ncer rar.<\/p>\n\n\n<p>Ara, <a href=\"https:\/\/www.upf.edu\/web\/biomed\/inici\/ca\/-\/asset_publisher\/Us0jfwFAevmx\/content\/formacio_insulinomes\/10193\/maximized\" target=\"_blank\" rel=\"noopener noreferrer\">un nou estudi<\/a> liderat pel grup de<strong> Lorenzo Pasquali<\/strong> al <a href=\"https:\/\/www.upf.edu\/web\/biomed\" target=\"_blank\" rel=\"noopener noreferrer\">Departament de Medicina i Ci\u00e8ncies de la vida, Universitat Pompeu Fabra (MELIS-UPF)<\/a> ha <strong>analitzat 42 insulinomes<\/strong> i ha descrit el mecanisme de formaci\u00f3 d&#8217;aquests tumors. Es tracta d&#8217;una acumulaci\u00f3 de mutacions en gens implicats en la regulaci\u00f3 de l&#8217;expressi\u00f3 g\u00e8nica a les c\u00e8l\u00b7lules beta.<\/p>\n\n\n<p class=\"wp-block-paragraph\">\u00abAquesta acumulaci\u00f3 de mutacions poc freq\u00fcents convergeix en un canvi al perfil epigen\u00e8tic de les c\u00e8l\u00b7lules beta\u00bb, explica <strong>Mireia Ramos,<\/strong> coprimera autora de l&#8217;estudi. Tot i que les mutacions s\u00f3n diferents a cada insulinoma, el <strong>nou perfil epigen\u00e8tic <\/strong>que es genera \u00e9s el mateix, i comporta un canvi a la cromatina que<strong> passa de reprimir a sobreactivar l&#8217;expressi\u00f3 g\u00e8nica d&#8217;una s\u00e8rie d&#8217;oncogens,<\/strong> factors de creixement i de transcripci\u00f3 i gens relacionats amb la producci\u00f3 d\u00b4insulina.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">M\u00e9s enll\u00e0 de la import\u00e0ncia per a aquest tumor, les <strong>c\u00e8l\u00b7lules beta pancre\u00e0tiques <\/strong>tamb\u00e9 estan implicades en altres malalties com la diabetis mellitus. Per aix\u00f2, \u00abestem especialment<strong> interessats en entendre com aquestes c\u00e8l\u00b7lules perden el control<\/strong>, com es desregula l&#8217;expressi\u00f3 dels seus gens i s&#8217;altera la secreci\u00f3 d&#8217;insulina\u00bb, comenta Pasquali. El grup ja est\u00e0 treballant per entendre millor el mecanisme pel qual es d\u00f3na un sobrecreixement d&#8217;aquestes c\u00e8l\u00b7lules.<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Un grup de recerca del MELIS-UPF descobreix una acumulaci\u00f3 de mutacions que canvia el perfil epigen\u00e8tic de les c\u00e8l\u00b7lules beta als insulinomes.<\/p>\n","protected":false},"author":6,"featured_media":43833,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[229,273],"new-type":[35],"class_list":["post-43841","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-cancer-pancreatic","tag-melis-upf-ca","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/43841","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=43841"}],"version-history":[{"count":5,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/43841\/revisions"}],"predecessor-version":[{"id":43846,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/43841\/revisions\/43846"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/43833"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=43841"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=43841"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=43841"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=43841"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}