{"id":4343,"date":"2017-01-15T14:25:20","date_gmt":"2017-01-15T14:25:20","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=4343"},"modified":"2019-01-31T16:49:54","modified_gmt":"2019-01-31T16:49:54","slug":"classificant-les-proteines-a-la-cel%c2%b7lula","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/classificant-les-proteines-a-la-cel%c2%b7lula\/","title":{"rendered":"Classificant les prote\u00efnes a la c\u00e8l\u00b7lula"},"content":{"rendered":"<p>En aquesta imatge de microsc\u00f2pia de fluoresc\u00e8ncia, que va fer Julia von Blume quan era al <a href=\"https:\/\/www.crg.eu\/en\/programmes-groups\/malhotra-lab\" target=\"_blank\" rel=\"noopener\">grup de recerca de Compartimentaci\u00f3 Intracel\u00b7lular<\/a>\u00a0dirigit per Vivek Malhotra al <a href=\"http:\/\/www.crg.eu\/\" target=\"_blank\" rel=\"noopener\">Centre de Regulaci\u00f3 Gen\u00f2mica (CRG)<\/a>, <strong>podem veure algunes <a href=\"https:\/\/ellipse.prbb.org\/ca\/cel%c2%b7lules-immortals\/\" target=\"_blank\" rel=\"noopener\">c\u00e8l\u00b7lules HeLa<\/a><\/strong>: el tipus cel\u00b7lular hum\u00e0 m\u00e9s utilitzat en recerca. Les c\u00e8l\u00b7lules van ser transfectades amb ADF\/cofilina amb una <strong>t\u00e8cnica anomenada siRNA<\/strong>, que inhibeix gens espec\u00edfics, en aquest cas la cofilina. Aleshores, les c\u00e8l\u00b7lules es van tenyir amb fal\u00b7lo\u00efdina (en color verd), TGN46 (en vermell) i DAPI (en blau).<\/p>\n<p>La fal\u00b7lo\u00efdina s&#8217;uneix als filaments d&#8217;actina, un dels <strong>elements del citoesquelet cel\u00b7lular<\/strong>. TGN46 \u00e9s un marcador per <strong>la xarxa del trans Golgi<\/strong>, un subdomini de l&#8217;aparell de Golgi. Aquest \u00e9s l&#8217;org\u00e0nul cel\u00b7lular que s\u2019encarrega d\u2019empaquetar les prote\u00efnes que s\u2019acaben de formar en ves\u00edcules de membrana i d\u2019enviar-les al seu dest\u00ed final. Finalment, DAPI tenyeix l&#8217;<strong>ADN al nucli cel\u00b7lular<\/strong>.<\/p>\n<p>En aquest experiment, els investigadors estaven <strong>investigant el paper de la cofilina<\/strong>, una mol\u00e8cula que regula la din\u00e0mica dels filaments d\u2019actina i sembla estar implicada en la classificaci\u00f3 i exportaci\u00f3 de prote\u00efnes des de l&#8217;aparell de Golgi.<\/p>\n<p><span style=\"color: #808080;\">Vols veure la teva foto aqu\u00ed? Envia\u2019ns imatges relacionades amb la ci\u00e8ncia o la vida al PRBB a<\/span> <a href=\"mailto:ellipse@prbb.org\" target=\"_blank\" rel=\"noopener\">ellipse@prbb.org.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>L&#8217;aparell de Golgi \u00e9s l&#8217;org\u00e0nul cel\u00b7lular que s\u2019encarrega d\u2019empaquetar les prote\u00efnes que s\u2019acaben de formar en ves\u00edcules de membrana i d\u2019enviar-les al seu dest\u00ed final. <\/p>\n","protected":false},"author":7,"featured_media":4340,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[269,265,323,329],"new-type":[40],"class_list":["post-4343","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-biologia-cellular","tag-crg-ca","tag-microscopia","tag-proteines","new-type-foto-de-la-setmana"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/4343","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=4343"}],"version-history":[{"count":5,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/4343\/revisions"}],"predecessor-version":[{"id":4388,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/4343\/revisions\/4388"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/4340"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=4343"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=4343"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=4343"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=4343"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}