{"id":43074,"date":"2026-05-11T14:24:49","date_gmt":"2026-05-11T12:24:49","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=43074"},"modified":"2026-05-11T14:27:49","modified_gmt":"2026-05-11T12:27:49","slug":"lera-dels-omics","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/lera-dels-omics\/","title":{"rendered":"L\u2019era dels \u201comics\u201d"},"content":{"rendered":"\n

La investigaci\u00f3 biol\u00f2gica d\u2019avui en dia \u00e9s a gran escala<\/strong>. Encara \u00e9s essencial fer experiments espec\u00edfics per entendre com funciona una determinada prote\u00efna o qu\u00e8 li passa a una c\u00e8l\u00b7lula o teixit concrets en un moment determinat. Per\u00f2 a gran part de la recerca puntera, els experiments biol\u00f2gics no tracten d\u2019un gen o d\u2019una prote\u00efna tan sols, sin\u00f3 de milers. Es tracta de les t\u00e8cniques que en angl\u00e8s es coneixen com \u201comics<\/strong>\u201d.<\/p>\n\n\n\n

La gen\u00f2mica <\/a><\/strong>(l\u2019estudi de milers de gens alhora) i la prote\u00f2mica <\/a><\/strong>(la determinaci\u00f3 de totes les prote\u00efnes d\u2019una c\u00e8l\u00b7lula) ja son comuns a molts laboratoris. Per\u00f2 no estan soles. Comencen a fer aparicions cada vegada m\u00e9s freq\u00fcents la transcript\u00f2mica <\/strong>(l\u2019an\u00e0lisi de tots els gens expressats en un moment donat), la metabol\u00f2mica <\/a><\/strong>(l\u2019estudi del metabolisme de l\u2019organisme a gran escala, analitzant les diferents vies alhora), la farmacogen\u00f2mica<\/a> <\/strong>(l\u2019estudi quantitatiu de com la gen\u00e8tica d\u2019un individu afecta la seva resposta a les drogues) o la fisi\u00f2mica <\/strong>(la din\u00e0mica de la fisiologia de tot l\u2019organisme).<\/p>\n\n\n\n

Estem preparats per l\u2019enorme quantitat d\u2019informaci\u00f3 que obtindrem d\u2019aquestes disciplines? Aquesta \u00e9s una de les q\u00fcestions que fan que la bioinform\u00e0tica <\/a><\/strong>sigui cada vegada m\u00e9s necess\u00e0ria en la recerca biom\u00e8dica<\/strong>, que al seu torn est\u00e0 esdevenint m\u00e9s multidisciplinar<\/strong>.<\/p>\n\n\n\n

Per entendre com funciona un organisme de forma global s\u00f3n necess\u00e0ries totes aquestes disciplines. L\u2019anomenada biologia de sistemes<\/strong> \u00e9s un camp dins la biomedicina que busca precisament la integraci\u00f3 de totes aquestes dades (dels milers de gens, tr\u00e0nscripts, prote\u00efnes i metab\u00f2lits) per comprendre finalment com som i com funcionem.<\/p>\n\n\n\n

<\/div>\n\n\n\n

Els \u201comics\u201d al PRBB<\/strong><\/h2>\n\n\n\n

Al PRBB, aquest canvi d\u2019escala no \u00e9s una idea abstracta. Diverses plataformes tecnol\u00f2giques dels centres que l\u2019integren ajuden els equips de recerca a generar dades \u00f2miques i a estudiar ADN, ARN i prote\u00efnes a gran escala. En l\u2019\u00e0mbit de la gen\u00f2mica, la Genomics Unit del CRG<\/a> ofereix serveis de seq\u00fcenciaci\u00f3 de nova generaci\u00f3 per a m\u00faltiples aplicacions d\u2019ADN i ARN, mentre que la Genomics Core Facility de la UPF<\/a> proporciona m\u00e8todes d\u2019an\u00e0lisi d\u2019ADN i ARN, incloent seq\u00fcenciaci\u00f3, PCR, control de qualitat i suport bioinform\u00e0tic. En prote\u00f2mica, la CRG\/UPF Proteomics Unit<\/a> dona suport a la recerca biom\u00e8dica amb serveis d\u2019an\u00e0lisi de prote\u00efnes i tecnologies avan\u00e7ades d\u2019espectrometria de masses. Aquestes infraestructures mostren com els \u201comics\u201d han passat de ser una promesa tecnol\u00f2gica a una eina habitual per entendre millor com funcionen les c\u00e8l\u00b7lules, els teixits i els organismes.<\/p>\n\n\n\n

<\/p>\n\n\n\n

<\/div>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Hi ha un munt de disciplines entorn els \u00abomics\u00bb, i totes formen part de la biologia de sistemes, que fan que la ci\u00e8ncia sigui cada cop m\u00e9s multidisciplinar.<\/p>\n","protected":false},"author":33,"featured_media":43075,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[30],"tags":[513,233,706,620],"new-type":[35],"class_list":["post-43074","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ciencia-i-societat","tag-ciencia-al-descobert","tag-farmacologia","tag-genomica","tag-proteomica","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/43074","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/33"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=43074"}],"version-history":[{"count":9,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/43074\/revisions"}],"predecessor-version":[{"id":51468,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/43074\/revisions\/51468"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/43075"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=43074"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=43074"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=43074"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=43074"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}