{"id":42859,"date":"2024-06-06T12:14:36","date_gmt":"2024-06-06T10:14:36","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=42859"},"modified":"2024-06-06T12:14:38","modified_gmt":"2024-06-06T10:14:38","slug":"organitzar-els-embrions-la-feina-de-nkx1-2","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/organitzar-els-embrions-la-feina-de-nkx1-2\/","title":{"rendered":"Organitzar els embrions: la feina de NKX1-2"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Quan un <strong>embri\u00f3<\/strong> es desenvolupa,&nbsp;augmenta el seu nombre de c\u00e8l\u00b7lules, aquestes s\u2019especialitzen i tenen lloc multitud d\u2019altres processos. Per\u00f2 tot aix\u00f2 no es dona a l\u2019atzar: \u00e9s un <strong>proc\u00e9s altament regulat<\/strong>. De fet, una de les encarregades d\u2019organitzar totes aquestes etapes \u00e9s la <strong>prote\u00efna NKX1-2<\/strong>, estudiada recentment en una <a rel=\"noreferrer noopener\" href=\"https:\/\/www.crg.eu\/en\/news\/how-conductor-makes-sense-chaos-early-embryos#2\" target=\"_blank\">investigaci\u00f3<\/a> del laboratori de <strong><a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/maria-pia-cosma-crg-volem-mantenir-vius-els-ulls-dels-donants-durant-un-mes\/\" target=\"_blank\">Pia Cosma<\/a><\/strong> al <a rel=\"noreferrer noopener\" href=\"http:\/\/www.crg.eu\/\" target=\"_blank\">Centre de Regulaci\u00f3 Gen\u00f2mica (CRG)<\/a> en col\u00b7laboraci\u00f3 amb el <a rel=\"noreferrer noopener\" href=\"https:\/\/www.czbiohub.org\/ny\/\" target=\"_blank\">Chan Zuckerberg Biohub New York<\/a>.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">L\u2019NKX1-2 fa que tot passi a l\u2019instant que toca, ja que organitza la c\u00e8l\u00b7lula per a qu\u00e8 faci prote\u00efnes i per a qu\u00e8 ordeni i distribueixi els cromosomes correctament en moments concrets. Tot aix\u00f2 s\u2019ha vist en<strong> embrions de ratol\u00ed<\/strong>, ja que els processos de <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/how-an-egg-becomes-a-man-or-a-woman\/\" target=\"_blank\">desenvolupament primerenc<\/a> d&#8217;aquest animal i els humans s\u00f3n molt semblants. El que l\u2019equip investigador ha pogut observar \u00e9s que <strong>quan NKX1-2 no fa la seva funci\u00f3, no es produeixen <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/la-vida-dinamica-dels-ribosomes-per-ivan-milenkovic\/\" target=\"_blank\">ribosomes<\/a><\/strong>, les parts de la c\u00e8l\u00b7lula encarregades de fabricar prote\u00efnes. A m\u00e9s, els embrions d\u2019entre 2 i 4 c\u00e8l\u00b7lules amb NKX1-2 inhibida<strong> deixen de cr\u00e9ixer perqu\u00e8 no distribueixen b\u00e9 els cromosomes<\/strong>.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Quan la maquin\u00e0ria encarregada de fer que les c\u00e8l\u00b7lules es divideixin i els cromosomes se separin funciona malament, hi ha <strong>problemes en el desenvolupament embrionari<\/strong>, com quan hi ha un <strong>avortament espontani<\/strong>. \u00c9s per aix\u00f2 que con\u00e8ixer m\u00e9s en detall les <a href=\"https:\/\/ellipse.prbb.org\/ca\/una-proteina-de-la-resposta-immunitaria-interve-en-el-desenvolupament-embrionari\/\" target=\"_blank\" rel=\"noreferrer noopener\">prote\u00efnes<\/a> que regulen aquests processos permetr\u00e0 entendre millor qu\u00e8 passa i qu\u00e8 s\u2019hi pot fer. <\/p>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un estudi del CRG mostra que la prote\u00efna NKX1-2 t\u00e9 un paper crucial en la divisi\u00f3 cel\u00b7lular, la diferenciaci\u00f3 i la formaci\u00f3 d\u2019\u00f2rgans en el desenvolupament embrionari. <\/p>\n","protected":false},"author":33,"featured_media":42869,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[265,277,686,329],"new-type":[35],"class_list":["post-42859","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-crg-ca","tag-desenvolupament","tag-embrio","tag-proteines","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/42859","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/33"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=42859"}],"version-history":[{"count":14,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/42859\/revisions"}],"predecessor-version":[{"id":43084,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/42859\/revisions\/43084"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/42869"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=42859"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=42859"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=42859"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=42859"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}