{"id":42147,"date":"2024-04-25T14:46:42","date_gmt":"2024-04-25T12:46:42","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=42147"},"modified":"2024-04-25T14:46:44","modified_gmt":"2024-04-25T12:46:44","slug":"lestres-a-la-mitjana-edat-i-a-la-infancia-sassocien-al-risc-dalzheimer-en-edats-avancades","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/lestres-a-la-mitjana-edat-i-a-la-infancia-sassocien-al-risc-dalzheimer-en-edats-avancades\/","title":{"rendered":"L\u2019estr\u00e8s a la mitjana edat i a la inf\u00e0ncia s\u2019associen al risc d\u2019Alzheimer en edats avan\u00e7ades"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">L\u2019<a rel=\"noreferrer noopener\" href=\"https:\/\/www.isglobal.org\/ca\/\" target=\"_blank\">Institut de Salut Global de Barcelona (ISGlobal)<\/a> ha liderat <a rel=\"noreferrer noopener\" href=\"https:\/\/www.isglobal.org\/ca\/-\/vivencies-estressants-i-alzheimer\" target=\"_blank\">un estudi que associa les <strong>experi\u00e8ncies estressants en la mitjana edat<\/strong> amb <strong>el risc de patir Alzheimer<\/strong><\/a> en edats m\u00e9s avan\u00e7ades. Tamb\u00e9 han trobat una relaci\u00f3 entre <strong>l&#8217;estr\u00e8s infantil<\/strong> <strong>i <\/strong><a href=\"https:\/\/ellipse.prbb.org\/ca\/vida-sana-cervell-jove-lenvelliment-no-depen-nomes-de-ledat\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>la inflamaci\u00f3 del cervell<\/strong> en l\u2019edat adulta<\/a>, un tret tamb\u00e9 associat a l\u2019Alzheimer i altres malalties neurodegeneratives. En l\u2019estudi tamb\u00e9 hi ha participat el<a href=\"https:\/\/www.barcelonabeta.org\/ca\" target=\"_blank\" rel=\"noreferrer noopener\"> Barcelona\u03b2eta Brain Reserach Center <\/a>(BBRC), centre de recerca de la Fundaci\u00f3 Pasqual Maragall.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>La <a href=\"https:\/\/ellipse.prbb.org\/ca\/estudi-pensa-una-aposta-per-la-prevencio-primaria-en-lalzheimer\/\" target=\"_blank\" rel=\"noreferrer noopener\">dem\u00e8ncia<\/a> afecta 50 milions de persones<\/strong> a tot el m\u00f3n i s\u2019espera que aquest nombre es tripliqui cap a l\u2019any 2050. La causa m\u00e9s comuna de dem\u00e8ncia \u00e9s <a href=\"https:\/\/ellipse.prbb.org\/ca\/jugar-per-a-monitoritzar-el-declivi-cognitiu\/\" target=\"_blank\" rel=\"noreferrer noopener\">la malaltia d\u2019Alzheimer<\/a>, que es presenta amb acumulaci\u00f3 de diverses prote\u00efnes al cervell (\u03b2-amiloide i tau fosforilada), neurodegeneraci\u00f3, degradaci\u00f3 cognitiva i neuroinflamaci\u00f3 (inflamaci\u00f3 del cervell).&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">L\u2019equip de recerca ha fet un seguiment d\u2019aquests biomarcadors de l\u2019Alzheimer a <strong>una cohort de 1.290 persones,<\/strong> sense degeneraci\u00f3 cognitiva per\u00f2 amb antecedents familiars de la malaltia. Tamb\u00e9 se\u2019ls hi ha fet un seguiment de l\u2019estr\u00e8s, mitjan\u00e7ant &nbsp;entrevistes, i s\u2019ha buscat la relaci\u00f3 entre els esdeveniments vitals estressants i la pres\u00e8ncia d\u2019aquests<a href=\"https:\/\/ellipse.prbb.org\/ca\/assenyalen-dos-biomarcadors-sanguinis-que-detecten-els-primers-indicis-dalzheimer\/\" target=\"_blank\" rel=\"noreferrer noopener\"> biomarcadors <\/a>en edats m\u00e9s avan\u00e7ades. Nom\u00e9s s\u2019ha trobat una relaci\u00f3 en persones que han patit estr\u00e8s en la mitjana edat i la inf\u00e0ncia.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00abEls nostres resultats suggereixen que <strong>els mecanismes a trav\u00e9s dels quals els <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/com-podem-promoure-un-entorn-laboral-saludable-una-taula-rodona-sobre-el-benestar-mental\/\" target=\"_blank\">factors estressants de la vida<\/a> afecten la salut cerebral d&#8217;homes i dones s\u00f3n diferents<\/strong>: acumulaci\u00f3 de prote\u00efna amiloide en els homes i atr\u00f2fia cerebral en les dones\u00bb, explica <strong>Eider Arenaza-Urquijo<\/strong>, investigadora d\u2019ISGlobal.&nbsp; Mentre que en els homes de mitjana edat l\u2019estr\u00e8s provoca acumulaci\u00f3 de la prote\u00efna amiloide en edats m\u00e9s avan\u00e7ades, en les dones de mitjana edat s\u2019observa l\u2019evoluci\u00f3 a una disminuci\u00f3 de la subst\u00e0ncia grisa.&nbsp;&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Aquesta disminuci\u00f3 de&nbsp;subst\u00e0ncia grisa&nbsp;tamb\u00e9 s\u2019ha vist en persones amb historial psiqui\u00e0tric, junt amb l\u2019acumulaci\u00f3 de la prote\u00efna tau i la interleuquina-6, que tamb\u00e9 s\u00f3n biomarcadors de l\u2019Alzheimer. Aquestes dades suggereixen que <strong>les <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/youth-gems-unir-esforcos-per-millorar-la-salut-mental-del-jovent\/\" target=\"_blank\">persones amb historial psiqui\u00e0tric<\/a> s\u00f3n m\u00e9s vulnerables als esdeveniments vitals estressants<\/strong>, potser per tenir una menor capacitat per afrontar-los, i per tant presenten m\u00e9s risc neurodegeneratiu.&nbsp;<\/p>\n\n\n\n<div style=\"height:70px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Un estudi liderat per ISGlobal fa un seguiment a 1.290 persones amb antecedents familiars d\u2019Alzheimer i relaciona l\u2019estr\u00e8s amb diversos biomarcadors de la malaltia. A m\u00e9s, han vist que l\u2019estr\u00e8s afecta de forma diferent a homes i dones.<\/p>\n","protected":false},"author":32,"featured_media":42148,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[320,263,295,317],"new-type":[35],"class_list":["post-42147","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-alzheimer","tag-cervell","tag-isglobal-cat","tag-neurobiologia","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/42147","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/32"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=42147"}],"version-history":[{"count":11,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/42147\/revisions"}],"predecessor-version":[{"id":42271,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/42147\/revisions\/42271"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/42148"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=42147"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=42147"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=42147"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=42147"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}