{"id":39930,"date":"2024-01-03T15:53:34","date_gmt":"2024-01-03T14:53:34","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=39930"},"modified":"2024-04-30T15:25:35","modified_gmt":"2024-04-30T13:25:35","slug":"cultius-dorganoides-per-comprendre-el-cancer","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/cultius-dorganoides-per-comprendre-el-cancer\/","title":{"rendered":"Cultius d&#8217;organoides per comprendre el c\u00e0ncer"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Talya Dayton<\/strong>, una jove nova cap de grup recentment arribada al <a rel=\"noreferrer noopener\" href=\"https:\/\/www.embl.es\/\" target=\"_blank\"><strong>Laboratori Europeu de Biologia Molecular \u2013 Barcelona (EMBL Barcelona)<\/strong><\/a>, acaba de publicar <a rel=\"noreferrer noopener\" href=\"https:\/\/www.embl.org\/news\/science\/unveiling-the-vulnerabilities-of-pulmonary-neuroendocrine-tumours\/\" target=\"_blank\">un estudi que permet investigar els <\/a><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/www.embl.org\/news\/science\/unveiling-the-vulnerabilities-of-pulmonary-neuroendocrine-tumours\/\" target=\"_blank\">tumors neuroendocrins<\/a> (TNEs)<\/strong> mitjan\u00e7ant el cultiu de models d&#8217;organoides. Dayton ha aconseguit cultivar TNEs pulmonars per primer cop, treballant amb equips del <a rel=\"noreferrer noopener\" href=\"https:\/\/www.hubrecht.eu\/\" target=\"_blank\">Hubrecht Institute<\/a> i d&#8217;altres institucions d&#8217;Holanda, aix\u00ed com l&#8217;<a rel=\"noreferrer noopener\" href=\"https:\/\/www.iarc.who.int\/\" target=\"_blank\">Ag\u00e8ncia Internacional de Recerca del C\u00e0ncer (IARC)<\/a> a Li\u00f3, Fran\u00e7a.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Els TNEs s\u00f3n tumors rars, per\u00f2 la seva incid\u00e8ncia va en augment. <strong>L&#8217;evoluci\u00f3 d&#8217;aquests tumors \u00e9s molt dif\u00edcil de predir<\/strong> i, encara que alguns s\u00f3n de creixement lent, en alguns casos esdevenen agressius. El <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/cultivant-cellules-per-a-la-recerca\/\" target=\"_blank\">cultiu<\/a> al laboratori d&#8217;aquest tumor era fins ara molt dif\u00edcil, per\u00f2 Dayton i els seus col\u00b7laboradors, quan ella encara es trobava a l&#8217;Hubrecht Institute, van aconseguir crear <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/organoides-la-revolucio-de-les-tres-dimensions-en-una-placa-de-petri\/\" target=\"_blank\">organoides<\/a> de TNEs derivats de pacients. Gr\u00e0cies a aquests, s&#8217;ha pogut establir una relaci\u00f3 entre el <strong>factor de creixement epid\u00e8rmic (EFG)<\/strong> i el creixement d&#8217;aquests tumors, obrint vies per al desenvolupament de <strong>noves estrat\u00e8gies terap\u00e8utiques<\/strong>.<\/p>\n\n\n\n<div style=\"height:39px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u00abEstem utilitzant els models d&#8217;organoides tumorals derivats de pacients que vaig generar i descriure en aquest estudi per comprendre millor com els NETs progressen i es tornen agressius\u00bb.<\/p><p><strong>Talya Dayton<\/strong>, EMBL Barcelona<\/p><\/blockquote>\n\n\n\n<div style=\"height:48px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Aquest descobriment \u00e9s sorprenent perqu\u00e8 desafia la creen\u00e7a convencional que els tumors s\u00f3n independents dels factors de creixement. Segons aquest estudi amb <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/oganoids-derivats-de-pulmo\/\" target=\"_blank\">models d&#8217;organoides<\/a>, la <strong>depend\u00e8ncia dels factors de creixement <\/strong>podria explicar per qu\u00e8 els tumors creixen lentament \u2013 i perqu\u00e8, quan els tumors es tornen independents d&#8217;aquests factors, poden tornar-se agressius.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00abAquest treball que s&#8217;acaba de publicar estableix les <strong>bases de la recerca<\/strong> que el <a rel=\"noreferrer noopener\" href=\"https:\/\/www.embl.org\/groups\/dayton\/\" target=\"_blank\">meu grup<\/a> est\u00e0 realitzant actualment a EMBL Barcelona\u00bb, explica Dayton. \u00abEstem utilitzant els models d&#8217;organoides tumorals derivats de pacients que vaig generar i descriure en aquest estudi per comprendre millor com els NETs progressen i es tornen agressius\u00bb.<\/p>\n\n\n\n<div style=\"height:41px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Un nou model d&#8217;organoides imita el comportament dels tumors neuroendocrins i proporciona una poderosa eina per estudiar-los al laboratori.<\/p>\n","protected":false},"author":32,"featured_media":39952,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[269,312,279,561],"new-type":[35],"class_list":["post-39930","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-biologia-cellular","tag-cancer-ca","tag-embl-barcelona-ca","tag-organoides-ca","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/39930","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/32"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=39930"}],"version-history":[{"count":12,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/39930\/revisions"}],"predecessor-version":[{"id":42343,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/39930\/revisions\/42343"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/39952"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=39930"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=39930"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=39930"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=39930"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}