{"id":36422,"date":"2023-04-28T15:26:55","date_gmt":"2023-04-28T13:26:55","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=36422"},"modified":"2023-04-28T15:21:40","modified_gmt":"2023-04-28T13:21:40","slug":"sincronitzant-els-parasits-de-la-malaria","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/sincronitzant-els-parasits-de-la-malaria\/","title":{"rendered":"Sincronitzant els par\u00e0sits de la mal\u00e0ria"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Aquesta fotografia de la s\u00e8rie \u00abvida al laboratori\u00bb, es va fer a trav\u00e9s d\u2019un microscopi vertical al laboratori dirigit per la <strong>Maria Bernabeu<\/strong>, al <a rel=\"noopener noreferrer\" href=\"https:\/\/www.embl.es\/\" target=\"_blank\">Laboratori Europeu de Biologia Molecular \u2013 Barcelona (EMBL Barcelona)<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Com ens explica en <strong>Fran\u00e7ois Korbmacher<\/strong>, postdoc del laboratori que va preparar aquesta mostra, el grup estudia la <strong>interacci\u00f3 dels par\u00e0sits de la mal\u00e0ria amb els <a rel=\"noopener noreferrer\" href=\"https:\/\/ellipse.prbb.org\/ca\/un-xip-per-desxifrar-la-biologia-placentaria\/\" target=\"_blank\">vasos sanguinis del cervell <em>in vitro<\/em><\/a><\/strong> per a comprendre millor els <strong>mecanismes patog\u00e8nics de les infeccions de mal\u00e0ria. <\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Els par\u00e0sits de la mal\u00e0ria poden cr\u00e9ixer <em>in vitro <\/em>infectant gl\u00f2buls vermells, que el laboratori rep peri\u00f2dicament del banc de sang. Per a observar el creixement del par\u00e0sit, els membres del laboratori <strong>fixen i tenyeixen frotis de sang<\/strong>, un dels m\u00e8todes m\u00e9s r\u00e0pids per a avaluar el desenvolupament del par\u00e0sit i que <strong>s\u2019utilitza \u00e0mpliament per al diagn\u00f2stic en pa\u00efsos end\u00e8mics<\/strong>.<\/p>\n\n\n\n<div style=\"height:23px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-medium\"><img loading=\"lazy\" decoding=\"async\" width=\"283\" height=\"224\" src=\"https:\/\/ellipse.prbb.org\/wp-content\/uploads\/2023\/04\/smear-283x224.jpg\" alt=\"\" class=\"wp-image-36176\" srcset=\"https:\/\/ellipse.prbb.org\/wp-content\/uploads\/2023\/04\/smear-283x224.jpg 283w, https:\/\/ellipse.prbb.org\/wp-content\/uploads\/2023\/04\/smear-758x600.jpg 758w, https:\/\/ellipse.prbb.org\/wp-content\/uploads\/2023\/04\/smear-768x608.jpg 768w, https:\/\/ellipse.prbb.org\/wp-content\/uploads\/2023\/04\/smear-1536x1215.jpg 1536w, https:\/\/ellipse.prbb.org\/wp-content\/uploads\/2023\/04\/smear-2048x1620.jpg 2048w\" sizes=\"auto, (max-width: 283px) 100vw, 283px\" \/><figcaption>Frotis de sang per a estudiar el creixement del par\u00e0sit de la mal\u00e0ria. <\/figcaption><\/figure><\/div>\n\n\n\n<div style=\"height:33px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">El par\u00e0sit hum\u00e0 <strong>infecta els <a rel=\"noopener noreferrer\" href=\"https:\/\/ellipse.prbb.org\/ca\/phf19-regula-la-generacio-de-les-cellules-sanguinies\/\" target=\"_blank\">gl\u00f2buls vermells <\/a><\/strong>en un <strong>cicle asexual d\u2019unes 48 hores<\/strong>. Donat que s\u00f3n principalment els par\u00e0sits madurs els que mostren efectes patol\u00f2gics, el laboratori est\u00e0 interessat en els par\u00e0sits de m\u00e9s de 24 hores despr\u00e9s de la infecci\u00f3 dels gl\u00f2buls vermells. Per tant, els par\u00e0sits <strong>es cultiven de forma sincronitzada<\/strong>, per la qual cosa \u00e9s necessari avaluar el moment adequat mitjan\u00e7ant tincions de frotis sanguini. Per tant, l\u2019equip necessita fer un seguiment diari del creixement al laboratori, com fa la Mar\u00eda Gestal Mato en aquesta foto de sota.<\/p>\n\n\n\n<div style=\"height:28px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"799\" height=\"600\" src=\"https:\/\/ellipse.prbb.org\/wp-content\/uploads\/2023\/04\/IMG_20230418_114509-799x600.jpg\" alt=\"\" class=\"wp-image-36170\" srcset=\"https:\/\/ellipse.prbb.org\/wp-content\/uploads\/2023\/04\/IMG_20230418_114509-799x600.jpg 799w, https:\/\/ellipse.prbb.org\/wp-content\/uploads\/2023\/04\/IMG_20230418_114509-298x224.jpg 298w, https:\/\/ellipse.prbb.org\/wp-content\/uploads\/2023\/04\/IMG_20230418_114509-768x577.jpg 768w, https:\/\/ellipse.prbb.org\/wp-content\/uploads\/2023\/04\/IMG_20230418_114509-1536x1153.jpg 1536w, https:\/\/ellipse.prbb.org\/wp-content\/uploads\/2023\/04\/IMG_20230418_114509-2048x1538.jpg 2048w\" sizes=\"auto, (max-width: 799px) 100vw, 799px\" \/><\/figure>\n\n\n\n<div style=\"height:33px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Quan els par\u00e0sits estan llestos, poden utilitzar-se per a la <strong>perfusi\u00f3 de microvasos cerebrals <em>in vitro<\/em><\/strong><em> <\/em><strong>creats per <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/bioenginyeria-dorgans\/\" target=\"_blank\">bioenginyeria<\/a><\/strong>.<em> <\/em>D\u2019aquesta manera, el laboratori pot estudiar la interacci\u00f3 del par\u00e0sit amb els vasos sanguinis i el seu impacte en la seva salut i funci\u00f3.<\/p>\n\n\n\n<div style=\"height:28px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Aquesta fotografia de la s\u00e8rie \u00abvida al laboratori\u00bb, es va fer a trav\u00e9s d\u2019un microscopi vertical al laboratori dirigit per la Maria Bernabeu, al Laboratori Europeu de Biologia Molecular \u2013 Barcelona (EMBL Barcelona). Com ens explica en Fran\u00e7ois Korbmacher, postdoc del laboratori que va preparar aquesta mostra, el grup estudia la interacci\u00f3 dels par\u00e0sits de [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":36086,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[279,323,568],"new-type":[40],"class_list":["post-36422","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-embl-barcelona-ca","tag-microscopia","tag-sang","new-type-foto-de-la-setmana"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/36422","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=36422"}],"version-history":[{"count":2,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/36422\/revisions"}],"predecessor-version":[{"id":36424,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/36422\/revisions\/36424"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/36086"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=36422"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=36422"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=36422"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=36422"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}