{"id":35558,"date":"2023-03-06T10:23:39","date_gmt":"2023-03-06T09:23:39","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=35558"},"modified":"2023-03-06T10:23:41","modified_gmt":"2023-03-06T09:23:41","slug":"nous-avencos-pel-tractament-del-cancer-de-pell-colon-i-recte","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/nous-avencos-pel-tractament-del-cancer-de-pell-colon-i-recte\/","title":{"rendered":"Nous aven\u00e7os pel tractament del c\u00e0ncer de pell, c\u00f2lon i recte"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Dos equips investigadors de l\u2019<a rel=\"noreferrer noopener\" href=\"http:\/\/www.imim.es\/\" target=\"_blank\">Institut Hospital del Mar d\u2019Investigacions M\u00e8diques&nbsp;(IMIM)<\/a> han fet un parell de troballes que podrien millorar el tractament de diferents tipus de c\u00e0ncer. Han trobat procesos que expliquen la met\u00e0stasi (en c\u00e0ncer pell) o la manca de resposta al tractament (en c\u00e0ncer de c\u00f2lon i recte), i en ambd\u00f3s casos han trobat marcadors que poden ajudar a revertir la situaci\u00f3.<\/p>\n\n\n\n<div style=\"height:58px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>C\u00e0ncer de pell<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.imim.cat\/noticies\/1155\/descobreixen-un-marcador-per-saber-quan-un-tipus-de-cancer-de-pell-es-prepara-per-provocar-metastasi\">El primer estudi<\/a>, liderat per <strong>Inma Hern\u00e1ndez-Mu\u00f1oz<\/strong> del grup de recerca en <a rel=\"noreferrer noopener\" href=\"https:\/\/www.imim.es\/programesrecerca\/rct\/malatiesdermatol_giquesinflamat_ries.html\" target=\"_blank\">Malalties inflamat\u00f2ries i neopl\u00e0siques dermatol\u00f2giques <\/a>de l&#8217;IMIM, aporta noves dades sobre com el <strong>carcinoma escat\u00f3s<\/strong> (un tipus de tumor de pell) fa <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/descobert-un-dels-mecanismes-clau-per-entendre-la-metastasi-tumoral\/\" target=\"_blank\">met\u00e0stasi<\/a>.\u00a0<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A partir de l\u2019estudi d&#8217;un centenar de tumors, han trobat que quan baixen els nivells de la prote\u00efna <strong>disquerina<\/strong>, s\u2019indueix un canvi en el metabolisme de les c\u00e8l\u00b7lules tumorals, que passen de consumir glucosa a alimentar-se de l\u00edpids, en concret de mol\u00e8cules de colesterol LDL, el conegut com a <a href=\"https:\/\/ellipse.prbb.org\/ca\/no-es-colesterol-bo-tot-el-que-lluu\/\" target=\"_blank\" rel=\"noreferrer noopener\">colesterol dolent<\/a>. Aix\u00f2 els hi permet sobreviure a la migraci\u00f3 fins als ganglis limf\u00e0tics i, d&#8217;all\u00e0, a altres \u00f2rgans on proliferar.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">L\u2019estudi tamb\u00e9 va mostrar com el tractament amb <strong>estatines<\/strong>, que es fan servir per combatre els alts nivells de LDL, feia remetre el metabolisme dels l\u00edpids i evitava l&#8217;inici del proc\u00e9s de met\u00e0stasi.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Aquest treball ha comptat amb la col\u00b7laboraci\u00f3 de la Unitat de Prote\u00f2mica del <a rel=\"noreferrer noopener\" href=\"http:\/\/www.crg.eu\/\" target=\"_blank\">Centre de Regulaci\u00f3 Gen\u00f2mica (CRG)<\/a> i la Universitat Pompeu Fabra.<\/p>\n\n\n\n<div style=\"height:59px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>C\u00e0ncer de c\u00f2lon i recte<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">El <a href=\"https:\/\/www.imim.cat\/noticies\/1152\/descobreixen-el-mecanisme-pel-qual-les-cel%c2%b7lules-tumorals-es-fan-resistents-a-la-quimioterapia-en-cancer-de-colon-i-recte\">segon estudi<\/a> surt del <a href=\"https:\/\/www.imim.cat\/programesrecerca\/cancer\/recerca_traslacional_en_microentorn_tumoral.html\" target=\"_blank\" rel=\"noreferrer noopener\">Laboratori de Recerca traslacional en microambient tumoral<\/a>, liderat per <strong>Alexandre Calon<\/strong>, i tamb\u00e9 hi han participat diversos instituts de recerca i universitats de Catalunya i Espanya, aix\u00ed com el CIBER del c\u00e0ncer (CIBERONC).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">De nou a partir de mostres de pacients amb c\u00e0ncer de c\u00f2lon i recte avan\u00e7at, per\u00f2 tamb\u00e9 <a href=\"https:\/\/ellipse.prbb.org\/ca\/arnau-busquets-imim-els-cientifics-som-els-primers-que-volem-el-benestar-dels-animals-si-lanimal-no-esta-be-el-resultat-no-sera-valid\/\" target=\"_blank\" rel=\"noreferrer noopener\">pr\u00e8viament en models de ratol\u00ed<\/a>, han observat que quan s\u2019utilitza el tractament de quimioter\u00e0pia usual en aquests casos, el plat\u00ed s\u2019acumula a les c\u00e8l\u00b7lules sanes que rodegen les tumorals. Aquesta acumulaci\u00f3, que pot durar m\u00e9s de dos anys, d\u00f3na lloc a l\u2019activaci\u00f3 d\u2019alguns gens que pot fer disminuir la sensibilitat del c\u00e0ncer al tractament.<\/p>\n\n\n\n<div style=\"height:51px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u00abHem descobert un mecanisme de resist\u00e8ncia a l&#8217;oxaliplat\u00ed i un marcador d&#8217;aquesta resist\u00e8ncia en pacients amb c\u00e0ncer de c\u00f2lon i recte\u00bb<br><strong>Jenniffer Linares,<\/strong> primera autora de l&#8217;estudi (IMIM)<\/p><\/blockquote>\n\n\n\n<div style=\"height:51px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">A la vegada, s&#8217;ha descobert que els nivells de la prote\u00efna <strong>periostina <\/strong>es pot utilitzar com a <strong>marcador <\/strong>per identificar els tumors que no respondran b\u00e9 a la quimioter\u00e0pia. Aixi, el grup est\u00e0 ara investigant si la combinaci\u00f3 de la quimioter\u00e0pia amb un p\u00e8ptid que evita que el plat\u00ed s&#8217;acumuli als fibroblasts pot permetre restaurar la capacitat del tractament.<\/p>\n\n\n\n<div style=\"height:46px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dos grups de recerca de l&#8217;IMIM han fet troballes que ajudaran a millorar el tractament de diferents tipus de c\u00e0ncer: un ha trobat perqu\u00e8 fa met\u00e0stasi el c\u00e0ncer de pell, i l&#8217;altre perqu\u00e8 alguns tumors de c\u00f2lon s\u00f3n resistents al tractament.<\/p>\n","protected":false},"author":6,"featured_media":35559,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[312,213,215,205,757],"new-type":[35],"class_list":["post-35558","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-cancer-ca","tag-imim","tag-metastasis-ca","tag-organismes-model","tag-tractament","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/35558","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=35558"}],"version-history":[{"count":19,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/35558\/revisions"}],"predecessor-version":[{"id":35590,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/35558\/revisions\/35590"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/35559"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=35558"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=35558"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=35558"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=35558"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}