{"id":33660,"date":"2022-11-23T10:07:52","date_gmt":"2022-11-23T09:07:52","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=33660"},"modified":"2022-11-23T10:07:54","modified_gmt":"2022-11-23T09:07:54","slug":"entenent-el-moviment-de-les-cellules-metastatiques","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/entenent-el-moviment-de-les-cellules-metastatiques\/","title":{"rendered":"Entenent el moviment de les c\u00e8l\u00b7lules metast\u00e0tiques"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/toni-celia-terrassa-imim-mes-del-90-de-les-morts-per-cancer-son-degudes-a-una-metastasi\/\" target=\"_blank\">El 90% de les <strong>morts<\/strong> relacionades amb el <strong>c\u00e0ncer<\/strong> es donen un cop les c\u00e8l\u00b7lules fan <strong>met\u00e0stasi<\/strong><\/a>. Entendre com les c\u00e8l\u00b7lules es desplacen, \u00e9s crucial per a descobrir noves dianes terap\u00e8utiques contra aquesta malaltia. Un equip multidisciplinar i internacional que inclou el <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/descobert-un-dels-mecanismes-clau-per-entendre-la-metastasi-tumoral\/\" target=\"_blank\">Laboratori de Fisiologia Molecular<\/a> del <a rel=\"noreferrer noopener\" href=\"https:\/\/www.upf.edu\/web\/biomed\" target=\"_blank\">Departament de Medicina i Ci\u00e8ncies de la Vida, Universitat Pompeu Fabra (MELIS-UPF)<\/a>, ha passat <a rel=\"noreferrer noopener\" href=\"https:\/\/www.upf.edu\/web\/focus\/noticies\/-\/asset_publisher\/qOocsyZZDGHL\/content\/id\/262478378\/maximized#.Y3srn3bMKUm\" target=\"_blank\">sis anys estudiant<\/a> com aquestes c\u00e8l\u00b7lules es desplacen i com s\u2019adapten a la viscositat.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Per a con\u00e8ixer com les c\u00e8l\u00b7lules metast\u00e0tiques es desplacen, l\u2019equip investigador ha dissenyat <strong>suports tridimensionals generats per <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/bioenginyeria-dorgans\/\" target=\"_blank\">bioenginyeria<\/a><\/strong> i ha utilitzat <strong>microsc\u00f2pia d\u2019alta resoluci\u00f3 <\/strong>per observar els moviments i l\u2019activitat el\u00e8ctrica. Un primer estudi ha mostrat com el transport d\u2019ions permet a les c\u00e8l\u00b7lules canceroses agafar aigua de la part anterior i expulsar-la en la posterior, per a propulsar-se. I una segona investigaci\u00f3 ha assenyalat com, contr\u00e0riament al que es podria pensar, els fluids m\u00e9s viscosos promouen la migraci\u00f3 cel\u00b7lular gr\u00e0cies als canvis en el citoesquelet.<\/p>\n\n\n\n<div style=\"height:23px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<blockquote class=\"wp-block-quote has-text-align-center is-layout-flow wp-block-quote-is-layout-flow\"><p>\u201c<em>Les c\u00e8l\u00b7lules tumorals poden moure\u2019s en espais confinats simplement transferint aigua de la part anterior a la posterior de la c\u00e8l\u00b7lula<\/em>\u201d<br><strong>Miguel Valverde, MELIS-UPF<\/strong><\/p><\/blockquote>\n\n\n\n<div style=\"height:23px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">L\u2019equip investigador ha observat que l\u2019encarregat de produir la <strong>propulsi\u00f3 per aigua<\/strong> \u00e9s el <strong><a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/travessant-els-canals\/\" target=\"_blank\">transport i\u00f2nic<\/a><\/strong> que provoquen el <a href=\"https:\/\/ellipse.prbb.org\/ca\/transportant-clor\/\" target=\"_blank\" rel=\"noreferrer noopener\">transportador <\/a>de sodi\/prot\u00f3 <strong>NHE1<\/strong>, concentrat a la part davantera de la c\u00e8l\u00b7lula, i el canal de clorur <strong>SWELL1<\/strong> que es troba a la part posterior. El canal NHE1 s\u2019encarrega de promoure l\u2019augment de la pressi\u00f3 osm\u00f2tica, que permet l\u2019entrada d\u2019aigua a la c\u00e8l\u00b7lula. Al mateix temps, aquest augment activa SWELL1, que expulsa l\u2019aigua, provocant el <strong>moviment<\/strong> sense necessitat que la c\u00e8l\u00b7lula estableixi interaccions amb el teixit que l\u2019envolta.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Pel que fa la <strong>viscositat<\/strong>, l&#8217;equip ha descobert que, quan les c\u00e8l\u00b7lules detecten un medi visc\u00f3s, no nom\u00e9s responen modificant el citoesquelet i els mecanismes motors, sin\u00f3 que tamb\u00e9 poden<strong> desenvolupar mem\u00f2ria<\/strong> a l&#8217;exposici\u00f3 a aquest medi. Concretament, l\u2019alta viscositat \u00e9s detectada per l\u2019<strong>actina<\/strong> de l\u2019esquelet cel\u00b7lular, <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/desxifrant-el-codi-de-senyalitzacio-cellular-el-paper-de-les-%ce%b2-arrestines\/\" target=\"_blank\">desencadenant una resposta molecular<\/a>. Aix\u00f2 activa el canal <strong><a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/descobert-un-dels-mecanismes-clau-per-entendre-la-metastasi-tumoral\/\" target=\"_blank\">TRPV4<\/a><\/strong>, que tamb\u00e9 desencadena una s\u00e8rie d\u2019esdeveniments que <strong>reforcen l\u2019esquelet i les prote\u00efnes motores<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Aquests treballs aporten, per primer cop, informaci\u00f3 sobre com les c\u00e8l\u00b7lules canceroses i els tumors es disseminen i com responen als canvis de viscositat dels diferents teixits durant la progressi\u00f3 de la <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/identificada-una-proteina-dunio-a-larn-involucrada-en-la-metastasi-del-melanoma\/\" target=\"_blank\">met\u00e0stasi<\/a>. \u201cCreiem que les mol\u00e8cules i la via que identifiquem al nostre estudi es poden fer servir com a objectius farmacol\u00f2gics per a possibles ter\u00e0pies contra el <a href=\"https:\/\/ellipse.prbb.org\/ca\/cancer-un-problema-de-frens-i-acceleradors\/\" target=\"_blank\" rel=\"noreferrer noopener\">c\u00e0ncer<\/a>\u201d conclou <strong>Miguel Valverde<\/strong>, investigador del MELIS-UPF. <\/p>\n\n\n\n<div style=\"height:46px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>El MELIS-UPF participa en un estudi internacional que conclou que les c\u00e8l\u00b7lules canceroses es desplacen gr\u00e0cies a la propulsi\u00f3 d\u2019aigua i que la viscositat elevada promou la seva migraci\u00f3.<\/p>\n","protected":false},"author":29,"featured_media":33716,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[559,312,273,323],"new-type":[35],"class_list":["post-33660","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-bioenginyeria","tag-cancer-ca","tag-melis-upf-ca","tag-microscopia","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/33660","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/29"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=33660"}],"version-history":[{"count":19,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/33660\/revisions"}],"predecessor-version":[{"id":33755,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/33660\/revisions\/33755"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/33716"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=33660"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=33660"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=33660"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=33660"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}