{"id":33569,"date":"2022-11-15T18:13:08","date_gmt":"2022-11-15T17:13:08","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=33569"},"modified":"2022-11-15T18:13:09","modified_gmt":"2022-11-15T17:13:09","slug":"un-peptid-que-vincula-la-diabetis-i-lalzheimer","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/un-peptid-que-vincula-la-diabetis-i-lalzheimer\/","title":{"rendered":"Un p\u00e8ptid que vincula la diabetis i l&#8217;Alzheimer"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">El <strong>p\u00e8ptid \u03b2-amiloide monom\u00e8ric <\/strong>\u00e9s secretat per totes les c\u00e8l\u00b7lules del cos, essent el <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/cicle-de-xerrades-cientifiques-el-nostre-cervell-aquest-gran-desconegut\/\" target=\"_blank\">cervell <\/a>all\u00e0 on m\u00e9s es produeix. Malgrat que la seva funci\u00f3 concreta encara es desconeix, <a rel=\"noreferrer noopener\" href=\"https:\/\/www.upf.edu\/web\/biomed\/news\/-\/asset_publisher\/CRcETTCV7Uyn\/content\/id\/262494621\/maximized\" target=\"_blank\">una col\u00b7laboraci\u00f3 recent<\/a> entre diversos grups del <a rel=\"noreferrer noopener\" href=\"https:\/\/www.upf.edu\/web\/biomed\" target=\"_blank\">Departament de Medicina i Ci\u00e8ncies de la Vida de la Universitat Pompeu Fabra (MELIS-UPF)<\/a> mostra com<strong> la seva funci\u00f3 canvia amb el pas dels anys<\/strong>, passant de contribuir a l&#8217;entrada de sucre a les neurones a la seva inhibici\u00f3.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">L\u2019equip investigador ha treballat amb cultius cel\u00b7lulars humans i preparat una an\u00e0lisi computacional que imita el funcionament fisiol\u00f2gic i patol\u00f2gic del <a href=\"https:\/\/ellipse.prbb.org\/ca\/la-intelligencia-artificial-revoluciona-el-mon-de-lestructura-de-proteines\/\" target=\"_blank\" rel=\"noreferrer noopener\">p\u00e8ptid<\/a>. Aix\u00f2 els ha perm\u00e8s veure que amb el pas del temps, el <strong>p\u00e8ptid \u03b2-amiloide<\/strong> es va <strong>agregant<\/strong> passant de la configuraci\u00f3 monom\u00e8rica a oligom\u00e8rica. Aquesta nova conformaci\u00f3 en fulles beta, <a href=\"https:\/\/ellipse.prbb.org\/ca\/assenyalen-dos-biomarcadors-sanguinis-que-detecten-els-primers-indicis-dalzheimer\/\" target=\"_blank\" rel=\"noreferrer noopener\">t\u00edpica de l&#8217;Alzheimer<\/a>, \u00e9s capa\u00e7 de <strong>bloquejar el receptor insul\u00ednic<\/strong> de les neurones, impedint que aquestes obtinguin la glucosa necess\u00e0ria per a funcionar.<\/p>\n\n\n\n<div style=\"height:23px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<blockquote class=\"wp-block-quote has-text-align-center is-layout-flow wp-block-quote-is-layout-flow\"><p>\u201c<em>Durant els primers estadis de l\u2019Alzheimer es veu una reducci\u00f3 de l\u2019activitat metab\u00f2lica de les neurones i de la captaci\u00f3 de la glucosa<\/em>\u201d <br><strong>Francisco Mu\u00f1oz, MELIS-UPF<\/strong><\/p><\/blockquote>\n\n\n\n<div style=\"height:23px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">L&#8217;estudi assenyala doncs, que l&#8217;acumulaci\u00f3 del \u03b2-amiloide que provoca Alzheimer produeix al mateix temps, resist\u00e8ncia a la <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/descobert-un-estabilitzador-genomic-que-regula-un-gen-de-la-diabetis\/\" target=\"_blank\">insulina<\/a>, malmetent el metabolisme neuronal. Aquests resultats indiquen que \u201cestudiar medicaments que ja es fan servir amb \u00e8xit per al tractament de la <strong>diabetis de tipus 2<\/strong>, podria ser \u00fatil per al tractament de l\u2019Alzheimer\u201d, afegeix <strong><a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/de-lalzheimer-al-cannabis-activitats-de-la-setmana-mundial-del-cervell\/\" target=\"_blank\">Francisco Mu\u00f1oz<\/a><\/strong>, investigador del MELIS-UPF. \u00a0\u00a0<\/p>\n\n\n\n<div style=\"height:46px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>El MELIS-UPF lidera un estudi que mostra com l&#8217;acumulaci\u00f3 del p\u00e8ptid \u03b2-amiloide, causant de l&#8217;Alzheimer, tamb\u00e9 provoca resist\u00e8ncia a la insulina. <\/p>\n","protected":false},"author":29,"featured_media":33578,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[320,263,806,273],"new-type":[35],"class_list":["post-33569","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-alzheimer","tag-cervell","tag-diabetis","tag-melis-upf-ca","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/33569","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/29"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=33569"}],"version-history":[{"count":14,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/33569\/revisions"}],"predecessor-version":[{"id":33607,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/33569\/revisions\/33607"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/33578"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=33569"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=33569"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=33569"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=33569"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}