{"id":32516,"date":"2022-09-29T14:42:37","date_gmt":"2022-09-29T12:42:37","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=32516"},"modified":"2022-09-29T14:42:38","modified_gmt":"2022-09-29T12:42:38","slug":"una-proteina-de-la-resposta-immunitaria-interve-en-el-desenvolupament-embrionari","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/una-proteina-de-la-resposta-immunitaria-interve-en-el-desenvolupament-embrionari\/","title":{"rendered":"Una prote\u00efna de la resposta immunit\u00e0ria interv\u00e9 en el desenvolupament embrionari"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Aquesta imatge d&#8217;embrions de ratol\u00ed molt primerencs, pertany a un recent estudi de l&#8217;equip cient\u00edfic del <a rel=\"noreferrer noopener\" href=\"http:\/\/www.crg.eu\/\" target=\"_blank\">Centre for Genomic Regulation (CRG)<\/a> liderat per en <strong><a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/thomas-graf-crg-per-ser-un-cientific-amb-exit-cal-jugar-i-passar-sho-be\/\" target=\"_blank\">Thomas Graf<\/a><\/strong>, que ha descobert l&#8217;essencial rol de la <strong>citocina IL-6<\/strong> en  la diferenciaci\u00f3 cel\u00b7lular en les primeres etapes embrion\u00e0ries en mam\u00edfers.  Aix\u00ed, aquesta prote\u00efna, coneguda per actuar durant la <strong>resposta immunit\u00e0ria<\/strong> impulsada per una <strong>infecci\u00f3 bacteriana<\/strong>, sembla tenir tamb\u00e9 un paper important en el <a href=\"https:\/\/ellipse.prbb.org\/ca\/autosabotatge-durant-el-desenvolupament-embrionari-en-mamifers\/\"><strong>desenvolupament embrionari<\/strong> de mam\u00edfers<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Anteriorment l\u2019equip havia observat que la prote\u00efna <strong>C\/EBPa<\/strong>, que interv\u00e9 en la <strong>desdiferenciaci\u00f3 de c\u00e8l\u00b7lules adultes cap a c\u00e8l\u00b7lules pluripotents<\/strong>, requereix d\u2019IL-6 per a fer-ho, i que alhora C\/EBPa regula l\u2019expressi\u00f3 de la citocina. &nbsp;Aquesta troballa els va fer pensar que aquestes mol\u00e8cules podrien estar implicades tamb\u00e9 en el proc\u00e9s de <a href=\"https:\/\/ellipse.prbb.org\/ca\/troben-un-element-clau-de-la-diferenciacio-de-cel%c2%b7lules-mare-embrionaries\/\" target=\"_blank\" rel=\"noreferrer noopener\">formaci\u00f3 de c\u00e8l\u00b7lules mare (pluripotents) durant el desenvolupament embrionari.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Concretament, han estudiat com es formen dos teixits durant el desenvolupament: el <strong>trofectoderma<\/strong>, la capa externa de l\u2019embri\u00f3 que esdevindr\u00e0 la placenta, i la <strong>massa cel\u00b7lular interna<\/strong>, que donar\u00e0 lloc a les estructures de l\u2019embri\u00f3. Els resultats han mostrat que tant C\/EBPa com IL-6 s\u2019expressen a la capa externa, i que a la capa interior s\u2019expressa el receptor de la IL-6. Tamb\u00e9 han comprovat que <strong>nivells baixos d\u2019IL-6 retarden el progr\u00e9s de l\u2019embri\u00f3<\/strong>. Els resultats mostren per primera vegada que en el desenvolupament embrionari hi ha<strong> comunicaci\u00f3 del trofectoderma cap a la capa interna<\/strong>, i que, sorprenentment, hi est\u00e0 implicada una mol\u00e8cula que, en adults, participa en la inflamaci\u00f3.<\/p>\n\n\n\n<div style=\"height:23px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u00abAquest descobriment planteja la possibilitat que la via de senyalitzaci\u00f3 C\/EBPa IL-6 reguli altres gens restringits al trofectoderma i potser actui com a impulsor del desenvolupament d\u2019aquest teixit\u00bb<br><strong>Marcos Plana<\/strong>, primer autor de l&#8217;estudi (CRG)<\/p><\/blockquote>\n\n\n\n<div style=\"height:23px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Malgrat que els experiments s\u2019han realitzat amb cultius cel\u00b7lulars i <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/els-animals-en-la-recerca-biomedica\/\" target=\"_blank\">embrions de ratol\u00ed<\/a>, els resultats suggereixen que en humans es podria donar el mateix proc\u00e9s.<\/p>\n\n\n\n<div style=\"height:46px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Aquesta imatge d&#8217;embrions de ratol\u00ed molt primerencs, pertany a un recent estudi de l&#8217;equip cient\u00edfic del Centre for Genomic Regulation (CRG) liderat per en Thomas Graf, que ha descobert l&#8217;essencial rol de la citocina IL-6 en la diferenciaci\u00f3 cel\u00b7lular en les primeres etapes embrion\u00e0ries en mam\u00edfers. Aix\u00ed, aquesta prote\u00efna, coneguda per actuar durant la resposta [&hellip;]<\/p>\n","protected":false},"author":29,"featured_media":32521,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[265,277,411,205,221],"new-type":[40],"class_list":["post-32516","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-crg-ca","tag-desenvolupament","tag-immunologia","tag-organismes-model","tag-ratoli","new-type-foto-de-la-setmana"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/32516","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/29"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=32516"}],"version-history":[{"count":15,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/32516\/revisions"}],"predecessor-version":[{"id":32648,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/32516\/revisions\/32648"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/32521"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=32516"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=32516"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=32516"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=32516"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}