{"id":31293,"date":"2022-08-04T12:33:20","date_gmt":"2022-08-04T10:33:20","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=31293"},"modified":"2022-08-04T12:33:35","modified_gmt":"2022-08-04T10:33:35","slug":"equilibri-durant-el-desenvolupament-cerebral","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/equilibri-durant-el-desenvolupament-cerebral\/","title":{"rendered":"Equilibri durant el desenvolupament cerebral"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Aquesta foto del laboratori de la <strong><a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/cristina-pujades-dcexs-upf-la-vida-al-laboratori-pot-ser-molt-dura-per-aixo-hem-destar-segurs-que-almenys-som-capacos-dapassionar-nos\/\" target=\"_blank\">Cristina Pujades <\/a><\/strong>del <a rel=\"noreferrer noopener\" href=\"https:\/\/www.upf.edu\/web\/biomed\" target=\"_blank\">Departament de Medicina i Ci\u00e8ncies de la vida, Universitat Pompeu Fabra (MELIS-UPF) <\/a>ens il\u00b7lustra el seu darrer estudi, en qu\u00e8 han observat, en el<strong> model de <a rel=\"noreferrer noopener\" href=\"https:\/\/www.upf.edu\/web\/biomed\/news\/-\/asset_publisher\/CRcETTCV7Uyn\/content\/id\/258773039\/maximized\" target=\"_blank\">peix <\/a>zebra<\/strong>, els mecanismes d&#8217;<strong>equilibri entre les c\u00e8l\u00b7lules mare del cervell i les neurones diferenciades durant el <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/autosabotatge-durant-el-desenvolupament-embrionari-en-mamifers\/\" target=\"_blank\">desenvolupament embrionari<\/a><\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">El grup de recerca ha estudiat les <strong><a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/isabelle-vernos-crg-encara-em-sorpren-la-bellesa-duna-cel%c2%b7lula-en-divisio\/\" target=\"_blank\">divisions cel\u00b7lulars<\/a><\/strong> que es donen a la <strong>frontera entre <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/receptes-per-fer-organismes\/\" target=\"_blank\">romb\u00f2mers<\/a><\/strong>. Aquests s\u00f3n cadascun dels 7 segments en qu\u00e8 es divideix el<strong> romboenc\u00e8fal o cervell posterior<\/strong>, una zona conservada al cervell de tots els vertebrats, durant el desenvolupament embrionari. D&#8217;aquesta manera, han aconseguit observar com les c\u00e8l\u00b7lules mare cerebrals segueixen un <strong>tipus de divisi\u00f3 asim\u00e8trica<\/strong>. \u00c9s a dir, quan una c\u00e8l\u00b7lula progenitora es divideix <strong>formar\u00e0 una neurona diferenciada, <\/strong>que ja no es podr\u00e0 dividir, i una <strong>nova c\u00e8l\u00b7lula progenitora <\/strong>amb la capacitat de continuar dividint-se. Tal com s&#8217;observa a la foto, s\u00f3n les c\u00e8l\u00b7lules de la frontera entre romb\u00f2mers les que generen neurones (en verd) alhora que mantenen un reservori proliferatiu de <strong>c\u00e8l\u00b7lules mare progenitores<\/strong> (en magenta).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">La<strong> Carolyn Engel-Pizcueta<\/strong>, autora de l&#8217;estudi, explica que \u201cusant <strong><a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/crispr-millorada-per-editar-el-genoma-dels-insectes\/\" target=\"_blank\">CRISPR<\/a> <\/strong>hem aconseguit inserir un gen reporter i generar una<strong> <\/strong><a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/els-vasos-sanguinis-regulen-la-proliferacio-i-diferenciacio-de-les-neurones-sensorials\/\" target=\"_blank\"><strong>l\u00ednia transg\u00e8nica de peix zebra<\/strong> on les c\u00e8l\u00b7lules que s\u00f3n del nostre inter\u00e8s expressen un marcador fluorescent <\/a>de manera que les podem observar i seguir en el temps\u201d.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Aix\u00ed, s&#8217;han pogut dilucidar els mecanismes d&#8217;equilibri que mantenen la proporci\u00f3 necess\u00e0ria de c\u00e8l\u00b7lules mare i neurones al cervell. Aix\u00f2 \u00e9s de gran import\u00e0ncia ja que, com apunta <strong><a href=\"https:\/\/ellipse.prbb.org\/ca\/cristina-pujades-cexs-upf-canviar-visio-universitats-centres-recerca\/\" target=\"_blank\" rel=\"noreferrer noopener\">Pujades<\/a>, \u201cdurant la formaci\u00f3 del cervell cal mantenir els processos de proliferaci\u00f3 i diferenciaci\u00f3 i regular-los de forma molt precisa<\/strong>. Sense aquesta coordinaci\u00f3 poden sorgir problemes que ocasionin desordres neuronals\u201d.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Aquesta foto del laboratori de la Cristina Pujades del Departament de Medicina i Ci\u00e8ncies de la vida, Universitat Pompeu Fabra (MELIS-UPF) ens il\u00b7lustra el seu darrer estudi, en qu\u00e8 han observat, en el model de peix zebra, els mecanismes d&#8217;equilibri entre les c\u00e8l\u00b7lules mare del cervell i les neurones diferenciades durant el desenvolupament embrionari. El [&hellip;]<\/p>\n","protected":false},"author":27,"featured_media":30941,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[427,263,277,273,406],"new-type":[40],"class_list":["post-31293","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-cellules-mare","tag-cervell","tag-desenvolupament","tag-melis-upf-ca","tag-neurodesenvolupament","new-type-foto-de-la-setmana"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/31293","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/27"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=31293"}],"version-history":[{"count":4,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/31293\/revisions"}],"predecessor-version":[{"id":31532,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/31293\/revisions\/31532"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/30941"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=31293"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=31293"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=31293"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=31293"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}