{"id":30298,"date":"2022-05-30T18:06:52","date_gmt":"2022-05-30T16:06:52","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=30298"},"modified":"2022-05-31T15:58:18","modified_gmt":"2022-05-31T13:58:18","slug":"descoberta-una-relacio-positiva-entre-un-aminoacid-de-la-dieta-i-la-depressio","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/descoberta-una-relacio-positiva-entre-un-aminoacid-de-la-dieta-i-la-depressio\/","title":{"rendered":"Descoberta una relaci\u00f3 positiva entre un amino\u00e0cid de la dieta i la depressi\u00f3"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Investigadors de l\u2019<a rel=\"noreferrer noopener\" href=\"https:\/\/idibgi.org\/\" target=\"_blank\">Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Girona (IDIBGI)<\/a> i la <a rel=\"noreferrer noopener\" href=\"https:\/\/www.upf.edu\/inici\" target=\"_blank\">Universitat Pompeu Fabra (UPF)<\/a> han realitzat una recerca sobre el paper de la prolina en la depressi\u00f3. <a href=\"https:\/\/www.upf.edu\/web\/biomed\/news\/-\/asset_publisher\/CRcETTCV7Uyn\/content\/id\/257735006\/maximized\" target=\"_blank\" rel=\"noreferrer noopener\">L\u2019estudi<\/a> ha analitzat com afecta aquest amino\u00e0cid en humans, ratolins i mosques de la fruita i conclou que la <strong>relaci\u00f3 entre una dieta rica en prolina i la <\/strong><a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/tot-un-micromon-dins-teu\/\" target=\"_blank\"><strong>microbiota intestinal<\/strong><\/a> pot portar a un <strong>estat an\u00edmic m\u00e9s depressiu<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Els equips dirigits per <a rel=\"noreferrer noopener\" href=\"https:\/\/idibgi.org\/personal\/jose-manuel-fernandez-real-lemos\/\" target=\"_blank\">Jos\u00e9 Manuel Fern\u00e1ndez-Real<\/a> i <a rel=\"noreferrer noopener\" href=\"https:\/\/idibgi.org\/personal\/jordi-mayneris-perxachs\/\" target=\"_blank\">Jordi Mayneris-Perxachs<\/a> de l\u2019<a href=\"https:\/\/idibgi.org\/grups\/nes-nutricio-eumetabolisme-i-salut\/\" target=\"_blank\" rel=\"noreferrer noopener\">IDIBIG<\/a> i en <a href=\"https:\/\/www.upf.edu\/web\/neurophar\" target=\"_blank\" rel=\"noreferrer noopener\">Rafael Maldonado<\/a> de la UPF i adscrit a <a rel=\"noreferrer noopener\" href=\"https:\/\/www.imim.es\/\" target=\"_blank\">l\u2019Institut Hospital del Mar d\u2019Investigacions M\u00e8diques (IMIM)<\/a>, han estudiat com l\u2019amino\u00e0cid prolina, afecta l\u2019estat depressiu en humans. Per a fer-ho, el primer pas va ser passar un <strong>q\u00fcestionari<\/strong> per a mesurar l\u2019<strong>\u00e0nim depressiu<\/strong> en 116 pacients de l&#8217;Hospital Universitari Dr. Josep Trueta&nbsp;i van analitzar el tipus i quantitat <strong>d\u2019amino\u00e0cids a la seva dieta<\/strong>. L\u2019amino\u00e0cid m\u00e9s repetit entre els pacients m\u00e9s depressius va ser la <strong>prolina<\/strong> i en van analitzar les <strong>concentracions plasm\u00e0tiques<\/strong>. Els resultats van mostrar que, malgrat que les persones amb altes concentracions de prolina tendeixen a ser m\u00e9s depressives, l\u2019alt consum de l\u2019amino\u00e0cid no sempre comporta altes concentracions sangu\u00ednies. Va ser aix\u00f2 el que els va portar a pensar que la <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/descobreixen-marcadors-epigenetics-relacionats-amb-laddiccio-al-menjar\/\" target=\"_blank\">microbiota intestinal<\/a> podria tenir un <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/trobada-la-relacio-entre-lobesitat-i-la-deterioracio-de-la-memoria\/\" target=\"_blank\">paper en el transport de la prolina cap al cervell<\/a>.<\/p>\n\n\n\n<div style=\"height:61px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Transplantar microbiota a ratolins i mosques<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">El primer pas per a comprovar-ho va ser el <strong>trasplantament de microbiota dels participants de l&#8217;estudi a ratolins<\/strong>, mostrant que els rosegadors m\u00e9s deprimits eren aquells que rebien bacteris de participants amb altes concentracions de prolina. La segona comprovaci\u00f3 va analitzar l\u2019estat d\u2019\u00e0nim depressiu en <strong><a href=\"https:\/\/ellipse.prbb.org\/ca\/de-mosques-i-humans\/\">mosques de la fruita<\/a><\/strong> (<em>Drosophila<\/em>) introduint bacteris associats al consum de prolina en la seva dieta. Es va observar que les mosques que ingerien <em>Lactobacillus <\/em>\u2013associat a menys depressi\u00f3 en ratolins\u2013 eren m\u00e9s propenses a superar les dificultats que aquelles que ingerien <em>Enterobacter <\/em>\u2013associat a m\u00e9s depressi\u00f3 en humans\u2013.&nbsp; Per \u00faltim, l\u2019eliminaci\u00f3 dels canals cerebrals de transport de prolina en mosques gen\u00e8ticament modificades, va suposar l\u2019obtenci\u00f3 d\u2019individus molt m\u00e9s resilients a la depressi\u00f3.<\/p>\n\n\n\n<div style=\"height:61px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u201c<em>La demostraci\u00f3 que <em>el transplantament de microbiota<\/em><\/em> <em>transfereix el fenotip depressiu d\u2019humans a ratolins<\/em> <em>i genera alteracions en el transport de la prolina indica una possible associaci\u00f3 causal amb l\u2019estat d\u2019\u00e0nim depressiu<\/em>\u201d<br><em><strong>Rafael Maldonado <\/strong>(MELIS-UPF)<\/em><\/p><\/blockquote>\n\n\n\n<div style=\"height:61px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">L\u2019estudi demostra que la prolina t\u00e9 un efecte en l\u2019estat depressiu de les persones, els ratolins i les mosques i la descoberta del paper d\u2019aquest amino\u00e0cid en la malaltia, obre portes a plantejar<strong> noves vies de tractament m\u00e9s eficients per a la depressi\u00f3 basades en la dieta.<\/strong><\/p>\n\n\n\n<div style=\"height:61px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>L\u2019estudi liderat per l\u2019IDIBGI i la UPF revela que una dieta rica en prolina pot causar un estat m\u00e9s depressiu en humans, ratolins i mosques i que la microbiota intestinal tamb\u00e9 pot jugar un paper clau en la malaltia.<\/p>\n","protected":false},"author":29,"featured_media":30318,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26,4],"tags":[338,213,273,470,221],"new-type":[13,35],"class_list":["post-30298","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","category-research","tag-drosophila","tag-imim","tag-melis-upf-ca","tag-microbioma","tag-ratoli","new-type-news","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/30298","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/29"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=30298"}],"version-history":[{"count":26,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/30298\/revisions"}],"predecessor-version":[{"id":30415,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/30298\/revisions\/30415"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/30318"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=30298"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=30298"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=30298"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=30298"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}