{"id":29858,"date":"2022-11-03T10:47:03","date_gmt":"2022-11-03T09:47:03","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=29858"},"modified":"2022-11-04T12:27:22","modified_gmt":"2022-11-04T11:27:22","slug":"baldo-oliva-grib-per-funcionar-les-molecules-han-de-tenir-forma","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/baldo-oliva-grib-per-funcionar-les-molecules-han-de-tenir-forma\/","title":{"rendered":"Baldo Oliva (GRIB): \u00abPer funcionar, les mol\u00e8cules han de tenir forma\u00bb"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Per ser funcionals,<strong> les prote\u00efnes tenen una estructura<\/strong> determinada, que es <strong>modula <\/strong><a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/un-servidor-web-per-estudiar-les-xarxes-de-proteines-en-malalties\/\" target=\"_blank\"><strong>quan interaccionen<\/strong> les unes amb les altres<\/a>. Aquesta idea que aparentment pot semblar senzilla, fa anys que t\u00e9 intrigada a la comunitat cient\u00edfica, que intenta predir aquesta estructura. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">En el quart episodi de&nbsp;la segona temporada de <a rel=\"noreferrer noopener\" href=\"https:\/\/open.spotify.com\/show\/6CvUPu6hqk2vvBwJ7EqLYH?si=iJnSV3qcSJiJjCJuCz2zfw&amp;dl_branch=1\" target=\"_blank\">\u2018La mare de la ci\u00e8ncia\u2019<\/a>, descobrirem com s&#8217;estudia el &#8216;<strong>plegament de les prote\u00efnes<\/strong>&#8216; amb en&nbsp;<strong><a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/la-intelligencia-artificial-revoluciona-el-mon-de-lestructura-de-proteines\/\" target=\"_blank\">Baldo Oliva<\/a><\/strong>, cap del grup de <a rel=\"noreferrer noopener\" href=\"http:\/\/grib.imim.es\/about-us\/baldo-oliva\/\" target=\"_blank\">bioinform\u00e0tica estructural<\/a> al GRIB, un programa compartit entre l&#8217;<a rel=\"noreferrer noopener\" href=\"http:\/\/www.imim.es\/\" target=\"_blank\">Institut Hospital del Mar d\u2019Investigacions M\u00e8diques&nbsp;(IMIM)<\/a> i el <a rel=\"noreferrer noopener\" href=\"https:\/\/www.upf.edu\/web\/biomed\" target=\"_blank\">Departament de Medicina i Ci\u00e8ncies de la vida, Universitat Pompeu Fabra (MELIS-UPF)<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Con\u00e8ixer l&#8217;estructura de les prote\u00efnes \u00e9s clau per saber quina \u00e9s la seva part activa o com una mutaci\u00f3 pot afectar el seu funcionament. Per\u00f2 tamb\u00e9 \u00e9s una <strong>eina magn\u00edfica per a dissenyar<\/strong> noves mol\u00e8cules per fer materials o <strong>nous f\u00e0rmacs<\/strong>.  <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">L&#8217;estudi d&#8217;aquesta estructura, es basa en <strong>experiments te\u00f2rics<\/strong> on utilitzen <strong>programes inform\u00e0tics <\/strong>i <strong><a href=\"https:\/\/ellipse.prbb.org\/ca\/intel%c2%b7ligencia-artificial-el-camp-de-proves-definitiu\/\" target=\"_blank\" rel=\"noreferrer noopener\">eines d&#8217;intel\u00b7lig\u00e8ncia artificial<\/a><\/strong> per a comparar diferents seq\u00fc\u00e8ncies i patrons de plegament. Per\u00f2, curiosament, aquesta recerca de frontera conviu amb teories tant antigues com les lleis de Newton que ajuden a explicar el moviment de les mol\u00e8cules. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">I qu\u00e8 va passar l&#8217;estiu del 2021? Doncs que es van publicar <strong>Alpha Fold<\/strong> i <strong>RoseTTA Fold<\/strong>, dos softwares d&#8217;<strong>acc\u00e9s obert <\/strong>que permeten predir l&#8217;estructura de les prote\u00efnes. Tots dos <a href=\"https:\/\/ellipse.prbb.org\/ca\/la-intelligencia-artificial-revoluciona-el-mon-de-lestructura-de-proteines\/\" target=\"_blank\" rel=\"noreferrer noopener\">han revolucionat el camp<\/a> i han sigut classificats per la revista <em>Science<\/em> com a descobriment de l&#8217;any. I, malgrat que aquests programes encara tenen limitacions, ja han donat resposta a un dels enigmes m\u00e9s antics de la biomedicina.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Teniu ganes de saber-ne m\u00e9s? Escolteu-lo!<\/p>\n\n\n\n<figure class=\"wp-block-embed-spotify wp-block-embed is-type-rich is-provider-spotify wp-embed-aspect-21-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe title=\"Spotify Embed: EP04: El plegament de les prote\u00efnes amb el Baldo Oliva\" style=\"border-radius: 12px\" width=\"100%\" height=\"152\" frameborder=\"0\" allowfullscreen allow=\"autoplay; clipboard-write; encrypted-media; fullscreen; picture-in-picture\" loading=\"lazy\" src=\"https:\/\/open.spotify.com\/embed\/episode\/7zkXEZGIVdaxrGZRauWyBT?si=6ebc7f9b69ed41e0&#038;utm_source=oembed\"><\/iframe>\n<\/div><\/figure>\n\n\n\n<div style=\"height:66px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>En aquest episodi sentirem com l&#8217;estudi d&#8217;una de les q\u00fcestions m\u00e9s b\u00e0siques de la biologia, com \u00e9s el plegament de les prote\u00efnes, pot tenir un gran impacte en la ci\u00e8ncia que es far\u00e0 en els propers anys.<\/p>\n","protected":false},"author":26,"featured_media":33336,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[30],"tags":[550,261,515,213,765,273,764,329,617],"new-type":[35],"class_list":["post-29858","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ciencia-i-societat","tag-acces-obert","tag-bioinformatica","tag-divulgacio","tag-imim","tag-lmdlc","tag-melis-upf-ca","tag-podcast","tag-proteines","tag-somprbb","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/29858","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=29858"}],"version-history":[{"count":30,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/29858\/revisions"}],"predecessor-version":[{"id":33307,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/29858\/revisions\/33307"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/33336"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=29858"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=29858"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=29858"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=29858"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}