{"id":29661,"date":"2022-05-06T10:42:28","date_gmt":"2022-05-06T08:42:28","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=29661"},"modified":"2022-05-06T10:42:11","modified_gmt":"2022-05-06T08:42:11","slug":"completen-el-primer-atles-cellular-dun-macaco","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/completen-el-primer-atles-cellular-dun-macaco\/","title":{"rendered":"Completen el primer atles cel\u00b7lular d’un macaco"},"content":{"rendered":"\n

Un equip internacional d’investigadors ha aconseguit completar el primer atles cel\u00b7lular<\/a> d’un primat no hum\u00e0<\/strong>, Macaca fascicularis<\/em>. \u00c9s a dir, han aconseguit descriure tots els tipus cel\u00b7lulars del macaco i crear un mapa de les seves c\u00e8l\u00b7lules<\/strong>. Aquest aven\u00e7 ha estat possible gr\u00e0cies a la col\u00b7laboraci\u00f3 entre equips de recerca del BGI-Research, la Universitat de Jilin i els Instituts de Biomedicina i Salut de Guangzhou a la Xina, juntament amb equips de 35 institucions internacionals entre les quals hi ha el Departament de Medicina i Ci\u00e8ncies de la vida, Universitat Pompeu Fabra (MELIS-UPF)<\/a>.<\/p>\n\n\n\n

En aquest treball<\/a>, han analitzat el transcriptoma cel\u00b7lular<\/strong> \u2013 \u00e9s a dir, el conjunt de tots els ARN<\/a> presents en una c\u00e8l\u00b7lula \u2013 d’1,14 milions de c\u00e8l\u00b7lules<\/strong> de 45 teixits diferents<\/strong>. Aix\u00ed, han aconseguit identificar 113 tipus de c\u00e8l\u00b7lules principals<\/strong>, segons el patr\u00f3 d’ARNs que expressen, i han completat el primer atles cel\u00b7lular del cos d’un primat no hum\u00e0.<\/p>\n\n\n\n

Pura Mu\u00f1oz-C\u00e1noves<\/a><\/strong>, autora de l’estudi i l\u00edder del Grup de Recerca en Biologia Cel\u00b7lular<\/a> (MELIS-UPF), remarca el gran esfor\u00e7 realitzat per l’equip de la Xina. A m\u00e9s, afegeix que \u201caquest treball ser\u00e0 una refer\u00e8ncia fonamental i ser\u00e0 molt \u00fatil per a futurs estudis en primats<\/a>, humans inclosos, ja que ajudar\u00e0 a entendre la naturalesa de la nostra pr\u00f2pia esp\u00e8cie\u201d. Per exemple, aquest mapa a nivell unicel\u00b7lular pot ajudar a identificar quines c\u00e8l\u00b7lules metabolitzen els greixos<\/strong> (cosa que pot ajudar a entendre l’obesitat<\/a>), o quines c\u00e8l\u00b7lules regulen circuits neuronals del cervell<\/a><\/strong> (el que pot ajudar a buscar tractaments per a malalties neurol\u00f2giques), entre altres.<\/p>\n\n\n\n

<\/div>\n\n\n\n

\u00abAquest treball ser\u00e0 una refer\u00e8ncia fonamental, ja que ajudar\u00e0 a entendre la naturalesa de la nostra pr\u00f2pia esp\u00e8cie\u00bb<\/p>

Pura Mu\u00f1oz-C\u00e1noves<\/strong>, MELIS-UPF<\/p><\/blockquote>\n\n\n\n

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Evolutivament, els primats no humans s\u00f3n les esp\u00e8cies m\u00e9s properes a la humana. Per aix\u00f2, la creaci\u00f3 d’aquesta base de dades<\/strong> pot aportar informaci\u00f3 molt rellevant quant al desenvolupament de m\u00e8todes de diagn\u00f2stic i tractament<\/strong> de malalties, l’avaluaci\u00f3 de l’efic\u00e0cia dels f\u00e0rmacs<\/a> cl\u00ednics<\/strong> o l’an\u00e0lisi de l’evoluci\u00f3<\/a> cel\u00b7lular<\/strong> entre esp\u00e8cies.<\/p>\n\n\n\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

Un estudi internacional en qu\u00e8 ha participat el MELIS-UPF ha aconseguit identificar els 113 tipus de c\u00e8l\u00b7lules principals d’un macaco, generant aix\u00ed el primer atles cel\u00b7lular d’un primat no hum\u00e0.<\/p>\n","protected":false},"author":28,"featured_media":29614,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[555,269,708,273],"new-type":[35],"class_list":["post-29661","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-arn","tag-biologia-cellular","tag-genetica","tag-melis-upf-ca","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/29661","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/28"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=29661"}],"version-history":[{"count":6,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/29661\/revisions"}],"predecessor-version":[{"id":29681,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/29661\/revisions\/29681"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/29614"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=29661"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=29661"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=29661"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=29661"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}