{"id":28506,"date":"2022-03-11T16:15:20","date_gmt":"2022-03-11T15:15:20","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=28506"},"modified":"2022-03-25T10:26:59","modified_gmt":"2022-03-25T09:26:59","slug":"de-cellules-mare-a-cellules-beta-pancreatiques-funcionals","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/de-cellules-mare-a-cellules-beta-pancreatiques-funcionals\/","title":{"rendered":"De c\u00e8l\u00b7lules mare a c\u00e8l\u00b7lules beta pancre\u00e0tiques funcionals"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Un equip cient\u00edfic de la Universitat d&#8217;H\u00e8lsinki en col\u00b7laboraci\u00f3 amb el <a rel=\"noreferrer noopener\" href=\"http:\/\/www.crg.eu\/\" target=\"_blank\">Centre de Regulaci\u00f3 Gen\u00f2mica (CRG)<\/a> ha aconseguit crear <strong>per primera vegada <a href=\"https:\/\/ellipse.prbb.org\/ca\/ratolins-peixos-i-organoides-contra-la-diabetis\/\" target=\"_blank\" rel=\"noreferrer noopener\">c\u00e8l\u00b7lules beta pancre\u00e0tiques<\/a> funcionals<\/strong>, tant en cultius cel\u00b7lulars com en ratolins, <strong>a partir de c\u00e8l\u00b7lules mare<\/strong>. Fins ara, les investigacions dutes a terme en aquest camp no havien aconseguit obtenir c\u00e8l\u00b7lules beta pancre\u00e0tiques completament madures, per la qual cosa aquesta troballa suposa un aven\u00e7 de gran import\u00e0ncia.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a rel=\"noreferrer noopener\" href=\"https:\/\/www.crg.eu\/en\/news\/fully-functional-pancreatic-beta-cells-created-stem-cells-first-time\" target=\"_blank\">Aquesta investigaci\u00f3<\/a> pot obrir el cam\u00ed a un millor tractament de la <strong><a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/ratolins-peixos-i-organoides-contra-la-diabetis\/\" target=\"_blank\">diabetis <\/a>tipus 1<\/strong>. En aquesta patologia es produeix una <strong>destrucci\u00f3 de les c\u00e8l\u00b7lules beta del p\u00e0ncrees<\/strong>, les quals s\u00f3n les encarregades de produir la insulina, hormona que regula els nivells de sucre a la sang. Fins ara s&#8217;estaven realitzant <strong>trasplantaments de c\u00e8l\u00b7lules beta a\u00efllades del p\u00e0ncrees de donants<\/strong> per tractar la malaltia. Aquesta t\u00e8cnica, per\u00f2, \u00e9s <strong>complexa i poc habitual<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Aquest nou estudi ha aconseguit produir, a partir de<a href=\"https:\/\/ellipse.prbb.org\/ca\/cellules-mare-al-rescat-de-la-retina\/\" target=\"_blank\" rel=\"noreferrer noopener\"> c\u00e8l\u00b7lules mare<\/a>, c\u00e8l\u00b7lules que <strong>imiten en estructura i funci\u00f3<\/strong> a aquelles dels illots pancre\u00e0tics. A m\u00e9s, s&#8217;ha demostrat la <strong>viabilitat d&#8217;aquestes c\u00e8l\u00b7lules tant en <a href=\"https:\/\/ellipse.prbb.org\/ca\/cel%c2%b7lules-immortals\/\" target=\"_blank\" rel=\"noreferrer noopener\">cultius cel\u00b7lulars<\/a> com en <a href=\"https:\/\/ellipse.prbb.org\/ca\/els-animals-en-la-recerca-biomedica\/\" target=\"_blank\" rel=\"noreferrer noopener\">ratolins<\/a><\/strong>, comprovant no nom\u00e9s la secreci\u00f3 d&#8217;insulina, sin\u00f3 tamb\u00e9 el metabolisme de la glucosa, els canals i\u00f2nics i l&#8217;expressi\u00f3 g\u00e8nica d&#8217;aquestes c\u00e8l\u00b7lules. De fet, <strong>en ratolins<\/strong> s&#8217;ha observat que el trasplantament de les c\u00e8l\u00b7lules beta derivades de c\u00e8l\u00b7lules mare donava <strong>millors resultats respecte al metabolisme de glucosa<\/strong> que el trasplantament de c\u00e8l\u00b7lules beta a\u00efllades de donants.<\/p>\n\n\n\n<div style=\"height:62px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>Aquest estudi, el m\u00e9s complet fins ara, ha aconseguit crear c\u00e8l\u00b7lules que imiten en estructura i funci\u00f3 aquelles dels illots pancre\u00e0tics<\/p><\/blockquote>\n\n\n\n<div style=\"height:62px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">A m\u00e9s, segons apunta <strong>Diego Balboa<\/strong>, primer autor de l&#8217;estudi i investigador del CRG, \u201cpodem generar milions d&#8217;aquestes c\u00e8l\u00b7lules al laboratori i fer-nos preguntes sobre els mecanismes de la diabetis o els defectes als gens o a la maquin\u00e0ria cel\u00b7lular que fan que les c\u00e8l\u00b7lules fallin\u201d. I afegeix que \u201cdesentranyar les causes moleculars precises de la diabetis pot ajudar a identificar noves dianes terap\u00e8utiques i explorar els efectes de nous medicaments\u201d.<\/p>\n\n\n\n<div style=\"height:62px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>En un estudi on ha col\u00b7laborat el CRG s&#8217;han aconseguit crear per primer cop c\u00e8l\u00b7lules beta pancre\u00e0tiques funcionals a partir de c\u00e8l\u00b7lules mare.<\/p>\n","protected":false},"author":28,"featured_media":28502,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[427,265,806],"new-type":[35,43],"class_list":["post-28506","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-cellules-mare","tag-crg-ca","tag-diabetis","new-type-noticies","new-type-recomanem"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/28506","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/28"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=28506"}],"version-history":[{"count":6,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/28506\/revisions"}],"predecessor-version":[{"id":28528,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/28506\/revisions\/28528"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/28502"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=28506"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=28506"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=28506"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=28506"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}