{"id":27750,"date":"2022-02-04T10:03:16","date_gmt":"2022-02-04T09:03:16","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=27750"},"modified":"2022-02-04T10:02:24","modified_gmt":"2022-02-04T09:02:24","slug":"descobreixen-una-nova-proteina-protectora-davant-del-cancer-de-pell","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/descobreixen-una-nova-proteina-protectora-davant-del-cancer-de-pell\/","title":{"rendered":"Descobreixen una nova prote\u00efna protectora davant del c\u00e0ncer de pell"},"content":{"rendered":"\n

Des del Centro de Regulaci\u00f3n Gen\u00f3mica (CRG)<\/a> s’ha fet un estudi en ratolins<\/strong> que planteja una nova l\u00ednia de defensa contra el <\/a>c\u00e0ncer<\/a> de pell<\/strong>. Els resultats obtinguts mostren que la prote\u00efna CSDE1<\/strong> podria tenir un paper clau en la supressi\u00f3 de tumors.<\/p>\n\n\n\n

Segons aquesta investigaci\u00f3<\/a>, la prote\u00efna CSDE1 regula certs mecanismes moleculars relacionats amb la senesc\u00e8ncia<\/strong>. Aquest \u00e9s un proc\u00e9s en qu\u00e8 la c\u00e8l\u00b7lula alenteix el seu creixement, sense arribar a causar la mort cel\u00b7lular. Es tracta d’un mecanisme de defensa davant l’amena\u00e7a de desenvolupar un tumor<\/a><\/strong>, ja que frena l’activitat cel\u00b7lular.<\/p>\n\n\n\n

Tot i aix\u00f2, la prote\u00efna CSDE1 no nom\u00e9s actua en la supressi\u00f3 de tumors mitjan\u00e7ant l’activaci\u00f3 de la senesc\u00e8ncia. A l’estudi amb aquest model animal <\/a>tamb\u00e9 s’ha vist com exerceix un rol clau en la detenci\u00f3 de l’activitat d’una altra prote\u00efna, la YBX1<\/strong>. Aquesta promou el creixement i l’agressivitat dels tumors; per aix\u00f2 CSDE1, en suspendre la funci\u00f3 de YBX1, frena tamb\u00e9 l’activitat tumoral.<\/p>\n\n\n\n

<\/div>\n\n\n\n

\u201cLa prote\u00efna CSDE1 t\u00e9 una dualitat impredictible segons el tipus de c\u00e8l\u00b7lula i el teixit en qu\u00e8 es trobi\u201d<\/p>

F\u00e1tima Gebauer<\/strong><\/p><\/blockquote>\n\n\n\n

<\/div>\n\n\n\n

Tot i aix\u00ed, el paper de CSDE1 com a defensa contra els tumors no \u00e9s tan clar. Com si es tract\u00e9s d’un Dr. Jekyll i Mr. Hide cel\u00b7lular<\/strong>, en estudis previs es va veure certa implicaci\u00f3 d’aquesta prote\u00efna en l’aparici\u00f3 i la met\u00e0stasi d’altres tumors. F\u00e1tima Gebauer<\/strong>, l\u00edder de l’equip de recerca, explica que \u201cCSDE1 t\u00e9 una dualitat impredictible<\/strong> segons el tipus de c\u00e8l\u00b7lula i teixit on es trobi\u201d i afegeix que \u201ccon\u00e8ixer la causa principal d’aquest fenomen tindr\u00e0 grans implicacions en el descobriment de nous tractaments personalitzats contra el c\u00e0ncer<\/a>\u201d.<\/p>\n\n\n\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

Un estudi realitzat en ratolins pel CRG revela el paper clau de la prote\u00efna CSDE1 en la supressi\u00f3 de tumors i els mecanismes d’acci\u00f3 en el cas del c\u00e0ncer de pell.<\/p>\n","protected":false},"author":28,"featured_media":27731,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[312,265,329],"new-type":[35],"class_list":["post-27750","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-cancer-ca","tag-crg-ca","tag-proteines","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/27750","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/28"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=27750"}],"version-history":[{"count":5,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/27750\/revisions"}],"predecessor-version":[{"id":27756,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/27750\/revisions\/27756"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/27731"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=27750"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=27750"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=27750"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=27750"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}