{"id":27591,"date":"2022-01-27T14:20:04","date_gmt":"2022-01-27T13:20:04","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=27591"},"modified":"2022-03-04T10:09:36","modified_gmt":"2022-03-04T09:09:36","slug":"la-transcripcio-vista-molecula-a-molecula","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/la-transcripcio-vista-molecula-a-molecula\/","title":{"rendered":"La transcripci\u00f3 vista mol\u00e8cula a mol\u00e8cula"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Un estudi dirigit des del <a rel=\"noreferrer noopener\" href=\"http:\/\/www.crg.eu\/\" target=\"_blank\">Centre de Regulaci\u00f3 Gen\u00f2mica (CRG)<\/a> ha fet servir la <strong>microsc\u00f2pia de superresoluci\u00f3<\/strong> per aconseguir <strong>les imatges m\u00e9s precises fins ara de la <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/la-transcripcio-canvia-lestructura-de-ladn\/\" target=\"_blank\">transcripci\u00f3<\/a><\/strong>. Per aix\u00f2 han col\u00b7laborat amb l&#8217;Institut de Ci\u00e8ncies Fot\u00f2niques (ICFO), el Laboratori Bioland de l&#8217;Institut de Biomedicina i Salut de Guangzhou (GIBH), a la Xina, i la Universitat de Pennsilv\u00e0nia.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/es\/genes-proteinas-y-arn-no-codificante\/\" target=\"_blank\">La transcripci\u00f3 \u00e9s el pas de la informaci\u00f3 en forma d&#8217;ADN a l&#8217;ARN, en el cam\u00ed cap a la formaci\u00f3 de prote\u00efnes<\/a>. La <strong>t\u00e8cnica utilitzada permet obtenir la posici\u00f3 de mol\u00e8cules individuals<\/strong>, cosa que combinada amb an\u00e0lisis computacionals, ha perm\u00e8s obtenir m\u00e9s informaci\u00f3 sobre com es disposa l&#8217;ARN en una c\u00e8l\u00b7lula humana durant aquest proc\u00e9s.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Els resultats, amb una <strong>resoluci\u00f3 fins a 10 vegades m\u00e9s gran <\/strong>que l&#8217;aconseguida amb microsc\u00f2pia de fluoresc\u00e8ncia, mostren amb precisi\u00f3 nanom\u00e8trica que <strong>les mol\u00e8cules d&#8217;ARN acabades de transcriure s&#8217;organitzen en petits dominis<\/strong>. A m\u00e9s, s&#8217;ha observat com aquests nanodominis es relacionen f\u00edsicament amb la cromatina i la resta de maquin\u00e0ria de la transcripci\u00f3. Aix\u00ed, s&#8217;ha demostrat que \u201cla transcripci\u00f3 \u00e9s un proc\u00e9s m\u00e9s fi, prec\u00eds i regulat del que es pensava fins ara\u201d, segons apunta \u00c1lvaro Castells, investigador del GIBH i alumni del CRG.<\/p>\n\n\n\n<div style=\"height:70px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"602\" height=\"322\" src=\"https:\/\/ellipse.prbb.org\/wp-content\/uploads\/2022\/01\/imagen-2-1.png\" alt=\"\" class=\"wp-image-27545\" srcset=\"https:\/\/ellipse.prbb.org\/wp-content\/uploads\/2022\/01\/imagen-2-1.png 602w, https:\/\/ellipse.prbb.org\/wp-content\/uploads\/2022\/01\/imagen-2-1-400x214.png 400w\" sizes=\"auto, (max-width: 602px) 100vw, 602px\" \/><figcaption>Les imatges obtingudes presenten una resoluci\u00f3 10 vegades m\u00e9s gran que l&#8217;aconseguida amb les t\u00e8cniques de microsc\u00f2pia de fluoresc\u00e8ncia convencional. Cr\u00e8dit: CRG.<\/figcaption><\/figure><\/div>\n\n\n\n<div style=\"height:38px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">L&#8217;\u00fas d&#8217;aquesta t\u00e8cnica de microsc\u00f2pia ha obert la porta a comprendre millor el funcionament de la transcripci\u00f3 i organitzaci\u00f3 de les mol\u00e8cules durant aquest proc\u00e9s. Tal com diu <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/maria-pia-cosma-crg-volem-mantenir-vius-els-ulls-dels-donants-durant-un-mes\/\" target=\"_blank\">Pia Cosma<\/a>, investigadora principal del CRG i l\u00edder de l&#8217;estudi, \u201caquest estudi ens ha ajudat a <strong>visualitzar i ubicar els ARN emergents amb una precisi\u00f3 sense precedents<\/strong>\u201d, i afegeix que \u201cde cara al futur es podr\u00e0 fer servir aquest tipus de an\u00e0lisi per comprendre l&#8217;expressi\u00f3 gen\u00e8tica amb m\u00e9s precisi\u00f3\u201d.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>El CRG ha utilitzat les t\u00e8cniques de microsc\u00f2pia de superresoluci\u00f3 per visualitzar com s&#8217;organitza la transcripci\u00f3 a les c\u00e8l\u00b7lules humanes i per ubicar cadascun dels seus components amb precisi\u00f3 nanom\u00e8trica.<\/p>\n","protected":false},"author":28,"featured_media":27538,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[555,265,323],"new-type":[35,43],"class_list":["post-27591","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-arn","tag-crg-ca","tag-microscopia","new-type-noticies","new-type-recomanem"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/27591","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/28"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=27591"}],"version-history":[{"count":9,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/27591\/revisions"}],"predecessor-version":[{"id":27620,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/27591\/revisions\/27620"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/27538"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=27591"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=27591"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=27591"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=27591"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}