{"id":27046,"date":"2022-01-18T10:44:19","date_gmt":"2022-01-18T09:44:19","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=27046"},"modified":"2022-01-18T10:44:05","modified_gmt":"2022-01-18T09:44:05","slug":"la-interaccio-entre-mutacions-podria-ser-determinant-en-el-desenvolupament-del-cancer","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/la-interaccio-entre-mutacions-podria-ser-determinant-en-el-desenvolupament-del-cancer\/","title":{"rendered":"La interacci\u00f3 entre mutacions podria ser determinant en el desenvolupament del c\u00e0ncer"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Un <a rel=\"noreferrer noopener\" href=\"https:\/\/www.crg.eu\/ben_lehner\" target=\"_blank\">equip de biologia computacional<\/a> del <a rel=\"noreferrer noopener\" href=\"http:\/\/www.crg.eu\/\" target=\"_blank\">Centre de Regulaci\u00f3 Gen\u00f2mica (CRG)<\/a> ha <a rel=\"noreferrer noopener\" href=\"https:\/\/www.crg.eu\/en\/news\/one-mutation-or-two-researchers-discover-why-some-genes-require-one-or-two-hits-promote-cancer#2\" target=\"_blank\">participat recentment<\/a> en un estudi que ha llan\u00e7at llum sobre perqu\u00e8 una mateixa mutaci\u00f3 pot a vegades causar <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/un-grafiti-epic\/\" target=\"_blank\">c\u00e0ncer <\/a>i altres no. L&#8217;estudi, realitzat en col\u00b7laboraci\u00f3 amb el CNIO i l&#8217;IRB, ha concl\u00f2s que el secret est\u00e0 en les <strong>interaccions entre <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/el-genoma-huma-20-anys-de-historia\/\" target=\"_blank\">mutacions<\/a><\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/ellipse.prbb.org\/ca\/ivo-gut-cnag-crg-pan-cancer-ha-estat-el-projecte-de-sequenciacio-del-genoma-del-cancer-mes-gran-del-mon\/\" target=\"_blank\" rel=\"noreferrer noopener\">Utilitzant dades de l&#8217;Atlas de Genoma del C\u00e0ncer <\/a>(The Cancer Genome Atlas, TCGA), l&#8217;equip ha analitzat les <strong>xarxes d&#8217;interaccions<\/strong> que existeixen entre les alteracions gen\u00e8tiques de m\u00e9s de 200 gens presents en m\u00e9s de 10.000 tumors humans i ha comprovat que <strong>la capacitat d&#8217;una mutaci\u00f3 de provocar c\u00e0ncer dep\u00e8n de la seva relaci\u00f3 amb una altra mutaci\u00f3 i fins i tot d&#8217;aquesta parella de mutacions amb una tercera.<\/strong> \u00c9s a dir, la millor manera d&#8217;atacar una mutaci\u00f3 cancer\u00edgena podria ser, de fet, atacant una 2a o 3a mutaci\u00f3 relacionada.<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u201cFins ara, la recerca s&#8217;ha enfocat en les alteracions en un \u00fanic gen sobre el qual actuar amb f\u00e0rmacs, per\u00f2 aquest estudi implica que cal considerar les associacions entre diferents gens implicats en el c\u00e0ncer\u201d<br><strong>Solip Park<\/strong>, Cap del Grup de Gen\u00f2mica Computacional del C\u00e0ncer del CNIO i coautora de l&#8217;estudi.<\/p><\/blockquote>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Amb aquests resultats es podria millorar el <strong>diagn\u00f2stic gen\u00e8tic<\/strong> i, amb aix\u00f2, <strong>facilitar la <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/un-acord-estrategic-per-accelerar-el-desenvolupament-de-nous-farmacs\/\" target=\"_blank\">cerca de dianes terap\u00e8utiques<\/a><\/strong> que anessin dirigides cap a una o m\u00e9s de les mutacions que intervenen en un mateix tumor.<\/p>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Un estudi en qu\u00e8 ha participat el CRG ha analitzat, gr\u00e0cies al big data i a avan\u00e7ades t\u00e8cniques de computaci\u00f3, les interaccions entre mutacions de m\u00e9s de 10.000 tumors.<\/p>\n","protected":false},"author":9,"featured_media":27037,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26,4],"tags":[261,312,265,708,332],"new-type":[13,35],"class_list":["post-27046","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","category-research","tag-bioinformatica","tag-cancer-ca","tag-crg-ca","tag-genetica","tag-gens","new-type-news","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/27046","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=27046"}],"version-history":[{"count":4,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/27046\/revisions"}],"predecessor-version":[{"id":27075,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/27046\/revisions\/27075"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/27037"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=27046"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=27046"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=27046"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=27046"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}