{"id":27018,"date":"2022-01-07T10:36:07","date_gmt":"2022-01-07T09:36:07","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=27018"},"modified":"2022-02-08T10:53:23","modified_gmt":"2022-02-08T09:53:23","slug":"atles-cellulars-per-a-facilitar-el-diagnostic-i-tractament-de-diferents-malalties","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/atles-cellulars-per-a-facilitar-el-diagnostic-i-tractament-de-diferents-malalties\/","title":{"rendered":"Atles cel\u00b7lulars per a facilitar el diagn\u00f2stic i tractament de diferents malalties"},"content":{"rendered":"\n

Dos equips del Centre de Regulaci\u00f3 Gen\u00f2mica (CRG)<\/a>, en col\u00b7laboraci\u00f3 amb diverses institucions alemanes, han desenvolupat, a partir de l’expressi\u00f3 g\u00e8nica de diferents l\u00ednies cel\u00b7lulars, atles <\/strong>per a millorar els diagn\u00f2stics cl\u00ednics de malalties hematol\u00f2giques<\/strong> i impulsar l’oncologia de precisi\u00f3<\/strong>, respectivament.<\/p>\n\n\n\n

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Atles cel\u00b7lular de la sang<\/h2>\n\n\n\n

Investigadores i investigadors del CRG han col\u00b7laborat en la creaci\u00f3<\/a> de l’atles de les c\u00e8l\u00b7lules sangu\u00ednies<\/a> i de la medul\u00b7la \u00f2ssia<\/a> humana m\u00e9s detallat<\/strong> fins ara.<\/strong><\/p>\n\n\n\n

L’estudi s’ha basat en l’an\u00e0lisi de l’expressi\u00f3 g\u00e8nica de m\u00e9s de 100.000 c\u00e8l\u00b7lules<\/strong> i podria servir per a millorar les t\u00e8cniques de diagn\u00f2stic actuals.<\/p>\n\n\n\n

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\u00abLa citometria de flux es basa en marcadors i metodologies dels anys 90 que han demostrat \u00e9sser molt imprecisos. Necessitem definir marcadors que reflecteixin m\u00e9s de prop la biologia del sistema\u201d
Lars Velten<\/strong>, cap de grup del CRG i coautor de l’estudi.<\/p><\/blockquote>\n\n\n\n

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L’an\u00e0lisi aporta nova informaci\u00f3 sobre la formaci\u00f3 de la sang i el que succeeix quan aquest proc\u00e9s falla. Aix\u00ed, amb els marcadors trobats en l’estudi es podria millorar el diagn\u00f2stic i la predicci\u00f3<\/strong> de malalties de la sang com la leuc\u00e8mia<\/a>.<\/p>\n\n\n\n

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C\u00e8l\u00b7lules immunes dels c\u00e0ncers humans<\/h2>\n\n\n\n

Un altre equip investigador, del CNAG-CRG, ha analitzat<\/a> el microambient dels tumor<\/strong>s – el conjunt de c\u00e8l\u00b7lules sangu\u00ednies, c\u00e8l\u00b7lules immunit\u00e0ries i el teixit connectiu en la proximitat immediata d’un tumor. En concret, s’han enfocat en l’estudi de m\u00e9s de 300.000 c\u00e8l\u00b7lules immunit\u00e0ries procedents de 217 pacients i 17 tipus de tumor diferents<\/strong>.<\/p>\n\n\n\n

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\u201cAquest atles de c\u00e8l\u00b7lules immunes ens ajuda a visualitzar els tumors com mai els hav\u00edem vist abans\u201d
Holger Heyn<\/strong>, l\u00edder del grup de Single Cell Genomics del CNAG-CRG i \u00faltim autor de l\u2019estudi.<\/p><\/blockquote>\n\n\n\n

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L’an\u00e0lisi ha perm\u00e8s definir 6 perfils immunol\u00f2gics que permetrien classificar el tipus de tumor<\/a><\/strong> segons els tipus, estats i ubicaci\u00f3 de les c\u00e8l\u00b7lules immunes infiltrades dins d’aquest. Determinar aquest perfil immunol\u00f2gic del tumor podria ajudar a predir si un pacient es beneficiar\u00e0 de la immunoter\u00e0pia<\/a>.<\/p>\n\n\n\n

Amb aquests resultats, els autors esperen que \u00abl\u2019atles funcioni millor<\/strong> que les estrat\u00e8gies d\u2019estratificaci\u00f3 que s\u2019apliquen actualment<\/strong> a l\u2019hora de predir el pron\u00f2stic del pacient i la resposta a la immunoter\u00e0pia\u00bb.<\/p>\n\n\n\n

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Dos equips del CRG han estudiat en profunditat l’expressi\u00f3 g\u00e8nica de les c\u00e8l\u00b7lules sangu\u00ednies i les c\u00e8l\u00b7lules immunes que s’infiltren en els tumors.<\/p>\n","protected":false},"author":9,"featured_media":26952,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[761,312,265,708,413,635],"new-type":[35,43],"class_list":["post-27018","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-biomarcadors","tag-cancer-ca","tag-crg-ca","tag-genetica","tag-immunoterapia","tag-leucemia","new-type-noticies","new-type-recomanem"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/27018","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=27018"}],"version-history":[{"count":6,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/27018\/revisions"}],"predecessor-version":[{"id":27072,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/27018\/revisions\/27072"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/26952"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=27018"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=27018"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=27018"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=27018"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}