{"id":25831,"date":"2021-10-27T23:35:58","date_gmt":"2021-10-27T21:35:58","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=25831"},"modified":"2021-10-27T23:39:28","modified_gmt":"2021-10-27T21:39:28","slug":"identificat-un-nou-mecanisme-dautoreparacio-de-cellules-musculars-independent-de-les-cellules-mare-de-teixit","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/identificat-un-nou-mecanisme-dautoreparacio-de-cellules-musculars-independent-de-les-cellules-mare-de-teixit\/","title":{"rendered":"Identificat un nou mecanisme d’autoreparaci\u00f3 de c\u00e8l\u00b7lules musculars independent de les c\u00e8l\u00b7lules mare de teixit"},"content":{"rendered":"\n

El teixit muscular est\u00e0 sotm\u00e8s a un estr\u00e8s mec\u00e0nic constant a causa dels moviments de contracci\u00f3, que poden provocar danys cel\u00b7lulars. Per tant, aquest teixit, fet de c\u00e8l\u00b7lules fibroses multinucleades, es troba en constant regeneraci\u00f3.<\/p>\n\n\n\n

Normalment, la regeneraci\u00f3 muscular es basa en les c\u00e8l\u00b7lules mare musculars. Per\u00f2 ara personal investigador del laboratori de Biologia Cel\u00b7lular del Departament de Ci\u00e8ncies Experimentals i de la Salut, Universitat Pompeu Fabra (DCEXS-UPF)<\/a>, juntament amb personal del Centro Nacional de Investigationes Cardiovasculares (CNIC)<\/a>, CIBERNED<\/a> i l’Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes (iMM, Portugal)<\/a> han descrit un mecanisme regeneratiu alternatiu, independent de les c\u00e8l\u00b7lules mare del teixit<\/a><\/strong>. <\/p>\n\n\n\n

Aquest mecanisme aut\u00f2nom de la fibra muscular<\/strong> s’activa despr\u00e9s de la lesi\u00f3<\/strong>, quan els nuclis es desplacen al lloc del dany<\/strong>. Aix\u00ed, acceleren la reparaci\u00f3 de les unitats contr\u00e0ctils degut a l’augment de la s\u00edntesi de prote\u00efnes in situ<\/em><\/strong>.<\/p>\n\n\n\n

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\u201cEls nostres experiments amb c\u00e8l\u00b7lules musculars al laboratori van demostrar que el moviment dels nuclis als llocs de lesi\u00f3 conduien a l’augment local de mol\u00e8cules d’ARNm. Aquestes mol\u00e8cules es van traduir a prote\u00efnes al lloc de la lesi\u00f3 per actuar com a blocs de construcci\u00f3 per a poder reparar la musculatura\u201d<\/p>

William Roman<\/strong> – primer autor de l’estudi (DCEXS- UPF) <\/p><\/blockquote>\n\n\n\n

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Tot i que encara es desconeix el motiu del moviment dels nuclis<\/strong>, el personal investigador ha demostrat, per primera vegada, que aquest proc\u00e9s t\u00e9 una funci\u00f3.<\/p>\n\n\n\n

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\u201cAquest proc\u00e9s d’autoreparaci\u00f3 de la fibra muscular es produeix r\u00e0pidament, tant en ratolins com en humans, despr\u00e9s d’una lesi\u00f3 muscular indu\u00efda per l’exercici. Per tant representa un mecanisme de protecci\u00f3 eficient en temps i energia per a la reparaci\u00f3 de lesions menors\u201d<\/p>

Pura Mu\u00f1oz-C\u00e1noves<\/strong> – autora principal de l’estudi (DCEXS- UPF)<\/p><\/blockquote>\n\n\n\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

La reordenaci\u00f3 dels nuclis de les c\u00e8l\u00b7lules musculars impulsa aquest mecanisme de reparaci\u00f3 aut\u00f2nom que mostra, per primera vegada, una funci\u00f3 associada al moviment dels nuclis cel\u00b7lulars.<\/p>\n","protected":false},"author":26,"featured_media":25802,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[269,427,273],"new-type":[35],"class_list":["post-25831","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-biologia-cellular","tag-cellules-mare","tag-melis-upf-ca","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/25831","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=25831"}],"version-history":[{"count":10,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/25831\/revisions"}],"predecessor-version":[{"id":25860,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/25831\/revisions\/25860"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/25802"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=25831"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=25831"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=25831"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=25831"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}