{"id":25168,"date":"2021-09-22T11:47:20","date_gmt":"2021-09-22T09:47:20","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=25168"},"modified":"2021-09-22T11:47:31","modified_gmt":"2021-09-22T09:47:31","slug":"ratolins-peixos-i-organoides-contra-la-diabetis","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/ratolins-peixos-i-organoides-contra-la-diabetis\/","title":{"rendered":"Ratolins, peixos i organoides contra la diabetis"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Gr\u00e0cies a una combinaci\u00f3 de <strong>models de ratol\u00ed i peix zebra, aix\u00ed com d&#8217;organoides humans<\/strong>, equips investigadors del <a rel=\"noreferrer noopener\" href=\"https:\/\/www.crg.eu\/\" target=\"_blank\">Centre de Regulaci\u00f3 Gen\u00f2mica (CRG)<\/a>, IDIBELL i la Universitat de Barcelona<a rel=\"noreferrer noopener\" href=\"https:\/\/www.crg.eu\/en\/news\/pancreatic-beta-cell-boost-mice-paves-way-future-diabetes-treatments\" target=\"_blank\"> han descobert el <strong>paper cr\u00edtic del gen REST per augmentar el nombre de c\u00e8l\u00b7lules productores d\u2019insulina<\/strong><\/a> durant el desenvolupament del p\u00e0ncrees en ratol\u00ed i peix zebra.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">En aquesta imatge dels conductes pancre\u00e0tics postnatals de ratol\u00ed, del laboratori <strong>Diabetes i gen\u00f2mica regulatoria dirigit per Jorgue Ferrer<\/strong>, podem veure l\u2019experiment on els autors van inactivar REST i van utilitzar anticossos marcats amb diferents colors per detectar diferents tipus de c\u00e8l\u00b7lules pancre\u00e0tiques. Concretament, es van utilitzar anticossos dirigits contra la citoqueratina 19 (en verd) per visualitzar les c\u00e8l\u00b7lules del conducte, la insulina (en turquesa) per a les c\u00e8l\u00b7lules \u03b2 i la RFP (en vermell) per als conductes i algunes c\u00e8l\u00b7lules \u03b4 de l\u2019illot perif\u00e8ric. En blau, podem veure els nuclis cel\u00b7lulars.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Els investigadors i investigadores van trobar que el gen del factor de transcripci\u00f3 silenciador RE1 (<strong>REST<\/strong>) s\u2019expressava en c\u00e8l\u00b7lules pancre\u00e0tiques embrion\u00e0ries i en c\u00e8l\u00b7lules adultes que formen el conducte pancre\u00e0tic, per\u00f2 no en les c\u00e8l\u00b7lules \u03b2 adultes que produeixen insulina. <strong>Quan s\u2019inhibia l\u2019expressi\u00f3 de REST en ratolins i peixos d&#8217;hora, abans que es form\u00e9s el p\u00e0ncrees, els animals adults tenien el doble del nombre de c\u00e8l\u00b7lules \u03b2<\/strong> <strong>productores d\u2019insulina<\/strong>. Aix\u00f2 no succeia si la inhibici\u00f3 tenia lloc despr\u00e9s de la formaci\u00f3 del p\u00e0ncrees. Aix\u00f2 es demostra que REST \u00e9s un supressor de la diferenciaci\u00f3 endocrina.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Curiosament, per\u00f2, la inhibici\u00f3 de REST en <strong>organoides pancre\u00e0tics humans <\/strong>no va conduir a la formaci\u00f3 de c\u00e8l\u00b7lules \u03b2, tot i que va augmentar l&#8217;activitat dels gens endocrins. Aix\u00f2 demostra que<strong> REST no \u00e9s l&#8217;\u00fanic que entra en joc en la diferenciaci\u00f3 endocrina i la formaci\u00f3 de c\u00e8l\u00b7lules \u03b2<\/strong>. No obstant aix\u00f2, \u00absi algun dia arribem a un futur c\u00f2ctel de f\u00e0rmacs per augmentar les c\u00e8l\u00b7lules productores d&#8217;insulina al p\u00e0ncrees, sospito que els inhibidors REST formarien part de la recepta\u00bb, diu Ferrer, l\u00edder de l&#8217;estudi.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"has-text-color has-cyan-bluish-gray-color wp-block-paragraph\">Vols veure la teva foto aqu\u00ed? Envieu-nos les vostres imatges relacionades amb la ci\u00e8ncia o la vida al PRBB a ellipse@prbb.org.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gr\u00e0cies a una combinaci\u00f3 de models de ratol\u00ed i peix zebra, aix\u00ed com d&#8217;organoides humans, equips investigadors del Centre de Regulaci\u00f3 Gen\u00f2mica (CRG), IDIBELL i la Universitat de Barcelona han descobert el paper cr\u00edtic del gen REST per augmentar el nombre de c\u00e8l\u00b7lules productores d\u2019insulina durant el desenvolupament del p\u00e0ncrees en ratol\u00ed i peix zebra. [&hellip;]<\/p>\n","protected":false},"author":27,"featured_media":25129,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[265,205,561],"new-type":[40],"class_list":["post-25168","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-crg-ca","tag-organismes-model","tag-organoides-ca","new-type-foto-de-la-setmana"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/25168","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/27"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=25168"}],"version-history":[{"count":6,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/25168\/revisions"}],"predecessor-version":[{"id":25187,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/25168\/revisions\/25187"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/25129"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=25168"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=25168"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=25168"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=25168"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}