{"id":20957,"date":"2021-03-12T17:01:52","date_gmt":"2021-03-12T16:01:52","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=20957"},"modified":"2021-03-12T17:01:17","modified_gmt":"2021-03-12T16:01:17","slug":"descoberta-una-possible-diana-terapeutica-per-la-malaltia-de-huntington","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/descoberta-una-possible-diana-terapeutica-per-la-malaltia-de-huntington\/","title":{"rendered":"Possible diana terap\u00e8utica per la malaltia de Huntington"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Un <a rel=\"noreferrer noopener\" href=\"https:\/\/www.crg.eu\/en\/news\/new-therapeutic-target-huntingtons-treatment#2\" target=\"_blank\">estudi recent<\/a> de la UB, en el qual ha col\u00b7laborat el <a rel=\"noreferrer noopener\" href=\"http:\/\/www.crg.eu\/\" target=\"_blank\">Centre de Regulaci\u00f3 Gen\u00f2mica (CRG)<\/a>, ha determinat que els <strong>ARN petits (o sRNA)<\/strong>, unes mol\u00e8cules que <strong>intervenen en la regulaci\u00f3 dels <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/descobrint-el-naixement-de-gens-de-novo-en-llevats-mitjancant-la-transcriptomica\/\" target=\"_blank\">gens<\/a><\/strong>, s\u00f3n <strong>clau en el desenvolupament del Huntington<\/strong>, fent d&#8217;aquests una <strong>possible <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/la-ivermectina-podria-reduir-la-transmissio-viral-de-la-covid-19\/\" target=\"_blank\">diana terap\u00e8utica<\/a><\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Per analitzar el paper d&#8217;aquestes mol\u00e8cules, l&#8217;equip cient\u00edfic <strong>ha a\u00efllat sRNA del <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/el-cerebro-ilusionista\/\" target=\"_blank\">cervell <\/a>dels malalts de Huntington<\/strong> i de persones sanes per despr\u00e9s <strong>injectar-lo en el <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/la-memoria-a-curt-i-llarg-termini-segueixen-camins-diferents-al-cervell\/\" target=\"_blank\">cervell de ratolins<\/a> sans<\/strong>. Aix\u00ed han comprovat que els sRNA del cervell de pacients s\u00f3n suficients per al <strong>desenvolupament d&#8217;alteracions similars a la malaltia de Huntington en ratolins<\/strong>.<\/p>\n\n\n\n<div style=\"height:28px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u00abAquests resultats posen de manifest que diferents classes d&#8217;sRNA generats en el cervell dels pacients probablement participen en la patog\u00e8nesi\u00bb<br><strong>Eul\u00e0lia Mart\u00ed<\/strong>, investigadora al CRG i professora de la UB<\/p><\/blockquote>\n\n\n\n<div style=\"height:28px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Aquest <strong>innovador m\u00e8tode<\/strong> d&#8217;injectar sRNA d&#8217;humans al cervell de ratolins, s&#8217;ha realitzat en aquest estudi per primera vegada. Gr\u00e0cies a ell, la malaltia de Huntington, que provoca alteracions motores, cognitives i psiqui\u00e0triques, podria tenir una <strong>nova diana terap\u00e8utica<\/strong> a m\u00e9s de <strong>potencials <a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/terapia-del-cancer-basada-en-biomarcadors\/\" target=\"_blank\">biomarcadors <\/a>per a la seva detecci\u00f3.<\/strong><\/p>\n\n\n\n<div style=\"height:28px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Un estudi en el qual ha col\u00b7laborat el CRG ha analitzat el paper t\u00f2xic dels sRNA en la malaltia de Huntington. Aquestes petites mol\u00e8cules presents en el cervell dels malalts, podrien establir-se com a diana farmacol\u00f2gica.<\/p>\n","protected":false},"author":9,"featured_media":21250,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[555,263,265,332,317,225,221],"new-type":[40],"class_list":["post-20957","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-arn","tag-cervell","tag-crg-ca","tag-gens","tag-neurobiologia","tag-neurofarmacologia","tag-ratoli","new-type-foto-de-la-setmana"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/20957","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=20957"}],"version-history":[{"count":8,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/20957\/revisions"}],"predecessor-version":[{"id":21306,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/20957\/revisions\/21306"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/21250"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=20957"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=20957"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=20957"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=20957"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}