{"id":20487,"date":"2021-02-22T09:38:04","date_gmt":"2021-02-22T08:38:04","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=20487"},"modified":"2021-03-03T16:51:13","modified_gmt":"2021-03-03T15:51:13","slug":"les-persones-amb-sindrome-de-down-mes-susceptibles-a-la-covid-19","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/les-persones-amb-sindrome-de-down-mes-susceptibles-a-la-covid-19\/","title":{"rendered":"Les persones amb S\u00edndrome de Down, m\u00e9s susceptibles a la COVID-19"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">En un <a rel=\"noreferrer noopener\" href=\"https:\/\/www.crg.eu\/en\/news\/people-down-syndrome-are-genetically-susceptible-covid-19#2\" target=\"_blank\">recent estudi<\/a>, investigadores i investigadors del <a rel=\"noreferrer noopener\" href=\"http:\/\/www.crg.eu\/\" target=\"_blank\">Centre de Regulaci\u00f3 Gen\u00f2mica (CRG)<\/a> han identificat <strong>diferents factors gen\u00e8tics associats a la S\u00edndrome de Down<\/strong> que predisposarien a la <a href=\"https:\/\/ellipse.prbb.org\/ca\/la-ivermectina-podria-reduir-la-transmissio-viral-de-la-covid-19\/\" target=\"_blank\" rel=\"noreferrer noopener\">COVID-19<\/a>. Aix\u00ed, s&#8217;han confirmat les dades d&#8217;estudis previs que afirmaven una <strong>mortalitat fins a 10 vegades major<\/strong> en persones amb S\u00edndrome de Down a causa de la infecci\u00f3 per SARS-CoV-2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">L&#8217;equip, liderat per <strong><a rel=\"noreferrer noopener\" href=\"https:\/\/ellipse.prbb.org\/ca\/reconeixement-social-per-la-ciencia\/\" target=\"_blank\">Mara Dierssen<\/a><\/strong>, ha analitzat totes les dades transcript\u00f3miques p\u00fabliques de la trisomia, i ha trobat <strong>diferents gens<\/strong> que podrien influir en la <strong><a href=\"https:\/\/ellipse.prbb.org\/ca\/analitzada-la-susceptibilitat-a-la-covid-19-en-deu-especies-animals\/\" target=\"_blank\" rel=\"noreferrer noopener\">susceptibilitat <\/a>cap a la COVID-19<\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>TMPRSS2<\/strong>: Codifica un enzim fonamental per a l&#8217;<strong>entrada del SARS-CoV-2<\/strong> en les c\u00e8l\u00b7lules humanes. Es troba expressat un 60% m\u00e9s en persones amb SD, el qu\u00e8 implica major susceptibilitat a la infecci\u00f3 per Covid-19.<\/li><li><strong>CXCL10<\/strong>: Provoca una inflamaci\u00f3 descontrolada, un <strong>atac a les pr\u00f2pies c\u00e8l\u00b7lules pulmonars<\/strong> i \u00e9s una de les possibles causes de complicacions a llarg termini com la <strong>fibrosi pulmonar<\/strong>. Tamb\u00e9 t\u00e9 nivells m\u00e9s alts en SD, per tant major susceptibilitat a COVID-19.<\/li><li><strong>NLRP3<\/strong>: Fonamental contra les <strong>infeccions pat\u00f2genes<\/strong>. Es troba en baixos nivells en SD, el qu\u00e8 implica major susceptibilitat a la Covid-19.<\/li><li><strong>IFNAR1 i IFNAR2<\/strong>: Relacionats amb la resposta a l&#8217;interfer\u00f3, que <strong>atura la replicaci\u00f3 viral dins de les c\u00e8l\u00b7lules<\/strong>. Aquesta resposta \u00e9s extremadament activa en SD, el qu\u00e8 implica una menor susceptibilitat a la COVID-19.<\/li><\/ul>\n\n\n\n<div style=\"height:29px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u00abLes persones amb s\u00edndrome de Down s\u2019haurien d\u2019incloure urgentment als grups prioritaris de vacunaci\u00f3 contra la COVID-19 globalment.\u201d<br><strong>Mara Dierssen<\/strong> (CRG), autora de l&#8217;estudi.<\/p><\/blockquote>\n\n\n\n<div style=\"height:29px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Amb aquests resultats, i a l&#8217;espera de <strong>continuar validant-los en estudis futurs<\/strong>, les autores recalquen la import\u00e0ncia d&#8217;incloure a les persones amb S\u00edndrome de Down entre els <strong>grups de prioritat en els calendaris de vacunaci\u00f3<\/strong> <strong>contra la COVID-19<\/strong> de tot el m\u00f3n.<\/p>\n\n\n\n<div style=\"height:29px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Un estudi del CRG ha trobat diferents factors gen\u00e8tics de susceptibilitat cap a la infecci\u00f3 i suggereix que es consideri a les persones amb S\u00edndrome de Down com a grup prioritari per a la vacunaci\u00f3.<\/p>\n","protected":false},"author":9,"featured_media":20590,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[721,265,706,332,625,415],"new-type":[35],"class_list":["post-20487","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-coronavirus-ca","tag-crg-ca","tag-genomica","tag-gens","tag-sindrome-de-down","tag-vacunes","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/20487","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=20487"}],"version-history":[{"count":8,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/20487\/revisions"}],"predecessor-version":[{"id":20990,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/20487\/revisions\/20990"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/20590"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=20487"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=20487"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=20487"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=20487"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}