{"id":18818,"date":"2020-11-09T14:25:19","date_gmt":"2020-11-09T13:25:19","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=18818"},"modified":"2020-12-16T17:33:16","modified_gmt":"2020-12-16T16:33:16","slug":"26-me-per-a-desxifrar-els-misteris-de-la-biologia-cellular-i-tractar-el-deficit-cognitiu-en-sindrome-de-down","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/26-me-per-a-desxifrar-els-misteris-de-la-biologia-cellular-i-tractar-el-deficit-cognitiu-en-sindrome-de-down\/","title":{"rendered":"26 M\u20ac per a desxifrar els misteris de la biologia cel\u00b7lular i tractar el d\u00e8ficit cognitiu en s\u00edndrome de Down"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Els investigadors del <a rel=\"noreferrer noopener\" href=\"http:\/\/www.crg.eu\/\" target=\"_blank\">Centre de Regulaci\u00f3 Gen\u00f2mica (CRG)<\/a>, Vivek Malhotra i Thomas Surrey, formen part de <strong>dos consorcis internacionals que <a rel=\"noreferrer noopener\" href=\"https:\/\/www.crg.eu\/en\/news\/20-million-euros-unlock-secrets-cell-division-and-test-liquid-crystal-hypothesis\" target=\"_blank\">han rebut beques ERC Synergy, de 10 milions d&#8217;euros cadascuna<\/a><\/strong>. Aquest any, el programa de recerca i innovaci\u00f3 de la UE, <a rel=\"noreferrer noopener\" href=\"https:\/\/erc.europa.eu\/news\/erc-2020-synergy-grants-results\" target=\"_blank\">Horitz\u00f3 2020, ha atorgat 34 beques d&#8217;aquest tipus, d&#8217;entre els 440 projectes presentats<\/a>. Tots dos investigadors s&#8217;embarquen en estudis que intentaran recrear processos de biologia cel\u00b7lular b\u00e0sica <em>in vitro<\/em> per tal de comprendre&#8217;ls millor.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Malhotra <\/strong>s&#8217;unir\u00e0 a un projecte coordinat pel Centre Nacional de la Recherche Scientifique (CNRS) amb la participaci\u00f3 de l&#8217;University College de Londres i la Universitat Complutense de Madrid. Intentaran <strong>demostrar la seva hip\u00f2tesi que el sistema ER\/Golgi \u00e9s principalment un l\u00edquid amb una organitzaci\u00f3 interna per fases<\/strong>, en lloc de ser compartiments de membrana que es formen per duplicaci\u00f3 d&#8217;un preexistent, com es creu des de fa 50 anys. Els cient\u00edfics planegen sintetitzar el sistema ER\/Golgi a partir de prote\u00efnes pures amb propietats de formar condensats l\u00edquids <em>in vitro <\/em>i en c\u00e8l\u00b7lules intactes.<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u00abSi confirmem la nostra hip\u00f2tesi, literalment reescriurem la hist\u00f2ria de la biologia cel\u00b7lular\u00bb<br><strong>Vivek Malhotra<\/strong> &#8211; Professor de recerca ICREA, CRG<\/p><\/blockquote>\n\n\n\n<div style=\"height:22px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Surrey <\/strong>formar\u00e0 part d&#8217;un altre equip de recerca coordinat per l&#8217;Institut Max Planck de Fisiologia Molecular de Dortmund, amb la participaci\u00f3 del Laboratori Sainsbury de la Universitat de Cambridge. <strong>Intentaran redissenyar <em>in vitro<\/em> i modelar <em>in silico<\/em> <\/strong>(a l&#8217;ordinador) un dels processos m\u00e9s fonamentals de la vida: <strong>la divisi\u00f3 cel\u00b7lular<\/strong>.<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p><em>\u00ab<\/em>Com fan els enginyers, el nostre objectiu \u00e9s entendre com es divideix la c\u00e8l\u00b7lula recreant el motor de divisi\u00f3 a partir de les seves parts individuals\u00bb<strong> <\/strong><br><strong>Thomas Surrey<\/strong> &#8211; CRG<\/p><\/blockquote>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">L&#8217;<a rel=\"noreferrer noopener\" href=\"http:\/\/www.imim.es\/\" target=\"_blank\">Institut Hospital del Mar d\u2019Investigacions M\u00e8diques&nbsp;(IMIM)<\/a> coordinar\u00e0 el projecte de 5 anys <a href=\"https:\/\/www.imim.cat\/noticies\/927\/la-comissio-europea-atorga-un-ajut-de-sis-milions-deuros-a-un-projecte-liderat-per-linstitut-hospital-del-mar-dinvestigacions-mediques\" target=\"_blank\" rel=\"noreferrer noopener\"><em><strong>Improving Cognition in Down Syndrome (ICOD)<\/strong><\/em>, que <strong>rebr\u00e0 6 milions d&#8217;euros<\/strong><\/a> i ha estat un dels 75 projectes seleccionats durant l&#8217;\u00faltim any del programa Horitz\u00f3 2020 de la Uni\u00f3 Europea. El projecte, liderat per <strong>Rafael de la Torre<\/strong> i amb la col\u00b7laboraci\u00f3 de sis institucions d&#8217;Espanya, Fran\u00e7a i It\u00e0lia, <strong>posar\u00e0 a prova una nova ter\u00e0pia per tractar els d\u00e8ficits cognitius dels malalts de s\u00edndrome de Down<\/strong>. Aquest tractament compr\u00e8n una nova classe farmacol\u00f2gica, mai abans provada en humans, que implica inhibidors de senyalitzaci\u00f3 espec\u00edfics del receptor de cannabinoides1 (CB1-SSi).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Aquestes beques europees se sumen a altres <a href=\"https:\/\/ellipse.prbb.org\/ca\/nou-millions-deuros-arriben-al-prbb-per-a-la-recerca-puntera-de-joves-cientifics-i-cientifiques\/\" target=\"_blank\" rel=\"noreferrer noopener\">cinc \u00abStarting Grants\u00bb de l&#8217;ERC, valorades en 1,5 milions d&#8217;euros cadascuna, que van rebre investigadores i investigadors dels centres <\/a>del <a rel=\"noreferrer noopener\" href=\"http:\/\/www.prbb.org\/\" target=\"_blank\">Parc de Recerca Biom\u00e8dica de Barcelona (PRBB)<\/a> al setembre.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tres investigadors del CRG i de l&#8217;IMIM han rebut beques de la UE per dur a terme projectes multinacionals que milloraran el nostre coneixement de la biologia cel\u00b7lular b\u00e0sica i desenvoluparan una nova ter\u00e0pia per a persones amb s\u00edndrome de Down.<\/p>\n","protected":false},"author":6,"featured_media":18807,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[28,32],"tags":[265,213,617],"new-type":[35,43],"class_list":["post-18818","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-comunitat","category-vida-cientifica","tag-crg-ca","tag-imim","tag-somprbb","new-type-noticies","new-type-recomanem"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/18818","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=18818"}],"version-history":[{"count":3,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/18818\/revisions"}],"predecessor-version":[{"id":18822,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/18818\/revisions\/18822"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/18807"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=18818"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=18818"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=18818"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=18818"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}