{"id":18757,"date":"2020-11-06T17:10:29","date_gmt":"2020-11-06T16:10:29","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=18757"},"modified":"2020-11-06T17:10:14","modified_gmt":"2020-11-06T16:10:14","slug":"llarga-vida-al-muscul","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/llarga-vida-al-muscul\/","title":{"rendered":"Llarga vida al m\u00fascul"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">La <strong>regeneraci\u00f3 del m\u00fascul <\/strong>esquel\u00e8tic dep\u00e8n d&#8217;una poblaci\u00f3 espec\u00edfica de <strong>c\u00e8l\u00b7lules mare<\/strong> (anomenades <strong>c\u00e8l\u00b7lules sat\u00e8l\u00b7lit<\/strong>) que es troben en estat inactiu, com adormides, fins que alguna cosa &#8211; dany o estr\u00e8s &#8211; les emputxa a formar noves fibres musculars i a generar noves c\u00e8l\u00b7lules mare.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tot i que les <strong>funcions regeneratives d&#8217;aquestes c\u00e8l\u00b7lules mare disminueixen amb l&#8217;envelliment<\/strong>, un grup d&#8217;investigadors d&#8217;Europa i dels Estats Units <a rel=\"noreferrer noopener\" href=\"https:\/\/www.upf.edu\/web\/biomed\/inici\/-\/asset_publisher\/Us0jfwFAevmx\/content\/id\/238406960\/maximized#.X6VysmhKjIU\" target=\"_blank\">han identificat<\/a> <strong>un subgrup que mant\u00e9 la seva capacitat regenerativa al llarg del temps, disminuint nom\u00e9s a l&#8217;edat geri\u00e0trica<\/strong>. Aix\u00ed ho podem veure  en aquesta imatge del grup de recerca en Biologia Cel\u00b7lular del <a rel=\"noreferrer noopener\" href=\"https:\/\/www.upf.edu\/web\/biomed\" target=\"_blank\">Departament de Ci\u00e8ncies Experimentals i de la Salut, Universitat Pompeu Fabra (DCEXS-UPF)<\/a>, encap\u00e7alat per <strong>Pura Mu\u00f1oz-C\u00e1noves<\/strong>, qui ha liderat aquest estudi.<\/p>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>Diversos equips cient\u00edfics han identificat un subgrup de c\u00e8l\u00b7lules mare que mant\u00e9 la seva capacitat regenerativa al llarg del temps, disminuint nom\u00e9s a l&#8217;edat geri\u00e0trica.<\/p><\/blockquote>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">La primera columna de la imatge mostra c\u00e8l\u00b7lules musculars joves, al mig hi veiem c\u00e8l\u00b7lules velles i a la tercera columna podem veure teixit geri\u00e0tric. En verd (marcat amb la prote\u00efna faroescent GFP) podem observar les c\u00e8l\u00b7lules que conserven la capacitat regenerativa.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Aquest subconjunt de c\u00e8l\u00b7lules que, sorprenentment, resisteixen el pas del temps molt m\u00e9s del que s&#8217;esperava, ho fan <strong>a trav\u00e9s de l&#8217;activaci\u00f3 de la via de senyalitzaci\u00f3 FoxO<\/strong>. Aquesta via, associada a la longevitat, mant\u00e9 l&#8217;expressi\u00f3 d&#8217;un programa de gens juvenils.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Els resultats suggereixen que <strong>compostos que activen FoxO podrien tenir un efecte de rejoveniment sobre les c\u00e8l\u00b7lules mare musculars envellides<\/strong>, donant una mica d&#8217;esperan\u00e7a a les persones debilitades per la p\u00e8rdua de massa muscular &#8211; tant la gent gran com aquelles amb malalties neuromusculars, c\u00e0ncer, o malalties inflamat\u00f2ries.<\/p>\n\n\n\n<div style=\"height:36px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p style=\"color:#8a8e91\" class=\"has-text-color wp-block-paragraph\">Vols veure la teva foto aqu\u00ed? Envia\u2019ns imatges relacionades amb la ci\u00e8ncia o la vida al PRBB a&nbsp;<a rel=\"noreferrer noopener\" href=\"mailto:ellipse@prbb.org\" target=\"_blank\">ellipse@prbb.org.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>La regeneraci\u00f3 del m\u00fascul esquel\u00e8tic dep\u00e8n d&#8217;una poblaci\u00f3 espec\u00edfica de c\u00e8l\u00b7lules mare (anomenades c\u00e8l\u00b7lules sat\u00e8l\u00b7lit) que es troben en estat inactiu, com adormides, fins que alguna cosa &#8211; dany o estr\u00e8s &#8211; les emputxa a formar noves fibres musculars i a generar noves c\u00e8l\u00b7lules mare. Tot i que les funcions regeneratives d&#8217;aquestes c\u00e8l\u00b7lules mare disminueixen [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":18745,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[427,273],"new-type":[40],"class_list":["post-18757","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-cellules-mare","tag-melis-upf-ca","new-type-foto-de-la-setmana"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/18757","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=18757"}],"version-history":[{"count":5,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/18757\/revisions"}],"predecessor-version":[{"id":18764,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/18757\/revisions\/18764"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/18745"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=18757"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=18757"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=18757"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=18757"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}