{"id":18640,"date":"2020-11-03T13:02:35","date_gmt":"2020-11-03T12:02:35","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=18640"},"modified":"2020-11-03T13:29:21","modified_gmt":"2020-11-03T12:29:21","slug":"noves-eines-per-a-millorar-lanalisi-de-la-sequencia-i-estructura-del-genoma","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/noves-eines-per-a-millorar-lanalisi-de-la-sequencia-i-estructura-del-genoma\/","title":{"rendered":"Noves eines per a millorar l’an\u00e0lisi de la seq\u00fc\u00e8ncia i estructura del genoma"},"content":{"rendered":"\n

Dos nous estudis provinents del CNAG-<\/a>Centre de Regulaci\u00f3 Gen\u00f2mica (CRG)<\/a> ofereixen a la comunitat cient\u00edfica noves eines per a millorar les an\u00e0lisis gen\u00f2miques.<\/strong><\/p>\n\n\n\n

Un article del grup de Ivo Gut <\/a>descriu un m\u00e8tode que ajuda a avaluar la qualitat de les dades de sequenciaci\u00f3 gen\u00f2mica<\/a><\/strong>. Observant cinc par\u00e0metres, aquest pot classificar les dades d’acord amb la seva qualitat. Aix\u00f2 permet descartar les seq\u00fc\u00e8ncies de baixa qualitat que, si s’utilitzessin, podrien portar a conclusions falses o emmascarar resultats rellevants.<\/p>\n\n\n\n

Aquest m\u00e8tode resultar\u00e0 molt \u00fatil per a les diverses iniciatives internacionals existents en qu\u00e8 moltes institucions en diferents pa\u00efsos estan intentant seq\u00fcenciar milers de genomes, que s’hauran d’analitzar de forma conjunta.<\/p>\n\n\n\n

<\/div>\n\n\n\n

\u00abTroba la difer\u00e8ncia\u00bb<\/h2>\n\n\n\n

Un altre article, aquesta vegada del laboratori de Marc Mart\u00ed-Renom, descriu un nou algorisme per comparar l’organitzaci\u00f3 3D de diferents genomes<\/a><\/strong>; per exemple de dues esp\u00e8cies diferents, per identificar \u00e0rees amb una estructura 3D conservada, o d’individus sans i pacients amb c\u00e0ncer. Mitjan\u00e7ant l’an\u00e0lisi de similitud estructural, l’algorisme pot identificar quines regions del genom<\/a>a<\/a> estan empaquetades de manera diferent <\/a>en el pacient amb c\u00e0ncer, per ajudar a identificar qu\u00e8 podria haver sortit malament.<\/p>\n\n\n\n

\u00abEl nostre algoritme pot resultar molt \u00fatil per analitzar els genomes de c\u00e0ncer<\/strong>, ja que molts d’ells, aix\u00ed com passa en altres malalties, presenten reordenaments cromos\u00f2mics on parts d’un cromosoma es trenquen i es tornen a unir en altres llocs, canviant l’estructura 3D<\/a>\u00ab, diu S\u00edlvia Galan<\/strong>, una de les primeres coautores de l’estudi i estudiant de doctorad al CNAG.<\/p>\n\n\n\n

Aquest estudi es va realitzar en col\u00b7laboraci\u00f3 amb el grup de Gen\u00f2mica Regulat\u00f2ria i del Desenvolupament de l’MRC LMS i l’Institut Max Planck de Biomedicina Molecular a Alemanya.<\/p>\n\n\n\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

Un m\u00e8tode que avalua la qualitat d’una seq\u00fc\u00e8ncia gen\u00f2mica i un algorisme que escaneja l’estructura 3D de diferents genomes per buscar difer\u00e8ncies s\u00f3n dues de les \u00faltimes contribucions del CNAG.<\/p>\n","protected":false},"author":6,"featured_media":18624,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[265,289,706,654],"new-type":[35],"class_list":["post-18640","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-crg-ca","tag-genoma","tag-genomica","tag-sequenciacio","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/18640","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=18640"}],"version-history":[{"count":3,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/18640\/revisions"}],"predecessor-version":[{"id":18643,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/18640\/revisions\/18643"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/18624"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=18640"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=18640"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=18640"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=18640"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}