{"id":17977,"date":"2020-10-05T23:30:37","date_gmt":"2020-10-05T21:30:37","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=17977"},"modified":"2020-10-05T23:34:23","modified_gmt":"2020-10-05T21:34:23","slug":"trobats-els-mecanismes-darrera-la-millora-cognitiva-per-extracte-de-te-verd-en-sindrome-de-down","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/trobats-els-mecanismes-darrera-la-millora-cognitiva-per-extracte-de-te-verd-en-sindrome-de-down\/","title":{"rendered":"Trobats els mecanismes darrera la millora cognitiva per extracte de te verd en S\u00edndrome de Down"},"content":{"rendered":"\n

Investigadores i investigadors del Centre de Regulaci\u00f3 Gen\u00f2mica (CRG)<\/a>\u00a0han publicat un estudi<\/a> on es descriuen alguns dels mecanismes moleculars<\/strong> pels quals el galato\u00a0de\u00a0epigalocatequina\u00a0(EGCG\u00a0per les seves sigles en angl\u00e8s), procedent d’extractes de te verd, \u00e9s un efectiu tractament per a la millora cognitiva de persones amb S\u00edndrome de\u00a0Down<\/strong>, com ja havien demostrat pr\u00e8viament.<\/p>\n\n\n\n

L’estudi, dut a terme per un equip<\/a> liderat per\u00a0la Mara\u00a0Dierssen<\/a><\/strong>, ha estat realitzat en models de ratol\u00ed<\/a> que repliquen la S\u00edndrome de\u00a0Down<\/strong>, i ha servit per a identificar cinc xarxes de prote\u00efnes<\/strong>, crucials per al desenvolupament cognitiu, que es veuen afectades amb la trisomia del cromosoma 21<\/a><\/strong> que caracteritza la s\u00edndrome.<\/p>\n\n\n\n

Aix\u00ed, les autores han vist que a partir d’un tractament combinat<\/strong> de\u00a0EGCG\u00a0i una ter\u00e0pia experimental d’estimulaci\u00f3 cognitiva<\/strong> s’ha restaurat el 70% de les xarxes proteiques afectades<\/strong>, que han arribat a nivells fisiol\u00f2gics sans. A m\u00e9s, altres xarxes proteiques han estat potenciades en el que podria ser un \u00abmecanisme compensatori positiu<\/strong> que potencia les cascades relacionades amb la plasticitat involucrades en l’aprenentatge i la mem\u00f2ria\u201d.<\/p>\n\n\n\n

<\/div>\n\n\n\n

\u201cGr\u00e0cies a aquests resultats, les ter\u00e0pies combinat\u00f2ries prometedores impulsaran o prolongaran la millora cognitiva actual per al tractament de la discapacitat intel\u00b7lectual\u201d
Mara Dierssen<\/strong>
– Investigadora i autora principal de l’estudi del CRG – <\/p><\/blockquote>\n\n\n\n

<\/div>\n\n\n\n

Amb aix\u00f2, l’estudi permet avan\u00e7ar un pas m\u00e9s en la comprensi\u00f3 dels mecanismes moleculars<\/strong> que interfereixen en el desenvolupament neuronal en la S\u00edndrome de Down, i aferma les bases de futures ter\u00e0pies de millora cognitiva.<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Un equip cient\u00edfic del CRG ha descrit les vies d’acci\u00f3 d’un possible tractament que milloraria l’aprenentatge i la mem\u00f2ria a la S\u00edndrome de Down.<\/p>\n","protected":false},"author":9,"featured_media":17967,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[265,648,317,406,625],"new-type":[35],"class_list":["post-17977","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-crg-ca","tag-epigenetica","tag-neurobiologia","tag-neurodesenvolupament","tag-sindrome-de-down","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/17977","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=17977"}],"version-history":[{"count":14,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/17977\/revisions"}],"predecessor-version":[{"id":17997,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/17977\/revisions\/17997"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/17967"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=17977"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=17977"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=17977"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=17977"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}