{"id":16090,"date":"2020-06-18T13:21:52","date_gmt":"2020-06-18T11:21:52","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=16090"},"modified":"2020-06-18T13:21:53","modified_gmt":"2020-06-18T11:21:53","slug":"lestructura-3d-del-genoma-essencial-en-la-resposta-inflamatoria","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/lestructura-3d-del-genoma-essencial-en-la-resposta-inflamatoria\/","title":{"rendered":"L&#8217;estructura 3D del genoma, essencial en la resposta inflamat\u00f2ria"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><a rel=\"noreferrer noopener\" href=\"https:\/\/www.crg.eu\/en\/news\/3-d-shape-human-genome-essential-robust-inflammatory-response\" target=\"_blank\">L&#8217;estructura tridimensional del genoma hum\u00e0 \u00e9s essencial a l&#8217;hora de proporcionar una resposta inflamat\u00f2ria robusta<\/a>, segons un grup investigador liderat per Thomas Graf al <a rel=\"noreferrer noopener\" href=\"http:\/\/www.crg.eu\/\" target=\"_blank\">Centre de Regulaci\u00f3 Gen\u00f2mica (CRG)<\/a>. No obstant, s&#8217;ha comprovat que no \u00e9s vital per reprogramar c\u00e8l\u00b7lules d&#8217;un tipus cel\u00b7lular a un altre.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Degut a la seva mida, el genoma hum\u00e0 est\u00e0 plegat dins el nucli de les c\u00e8l\u00b7lules. Aquest empaquetament permet el contacte f\u00edsic dels gens amb altres gens o elements reguladors. Un contacte que, si el genoma no estigu\u00e9s plegat, no seria possible.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Aquest empaquetament, doncs, proporciona al genoma una estructura tridimensional, la qual es mant\u00e9 gr\u00e0cies a prote\u00efnes arquitect\u00f2niques. <strong>CTCF <\/strong>\u00e9s una d&#8217;elles, i de les m\u00e9s importants. Ajuda a donar forma a l&#8217;estructura tridimensional general del genoma.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><\/h2>\n\n\n\n<h2 class=\"wp-block-heading\"><\/h2>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>CTCF \u00e9s essencial pel desenvolupament embrionari, la reparaci\u00f3 de l&#8217;ADN i els cicles cel\u00b7lulars.<\/p><\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\"><\/h2>\n\n\n\n<h2 class=\"wp-block-heading\"><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">No est\u00e0 clar, per\u00f2, quin paper juga CTCF en la transdiferenciaci\u00f3 cel\u00b7lular &#8211; la conversi\u00f3 d&#8217;un tipus cel\u00b7lular en un altre.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Per a estudiar-ho, l&#8217;equip cient\u00edfic ha desenvolupat un sistema \u00fanic en el que les c\u00e8l\u00b7lules B humanes poden ser induides per esdevenir macr\u00f2fags. Els cient\u00edfics i cient\u00edfiques van observar que la transdiferenciaci\u00f3 seguia succeint, amb o sense CTCF, tot i que la forma del genoma hum\u00e0 canvi\u00ef. Per altra banda, per\u00f2, van observar que la manca de CTCF deteriora la capacitat de la c\u00e8l\u00b7lula a l&#8217;hora de proporcionar una resposta inflamat\u00f2ria completa.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Aquest \u00e9s un dels primers casos en els que es relaciona l&#8217;arquitectura del genoma i la resposta inflamat\u00f2ria.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>CTCF \u00e9s una de les prote\u00efnes arquitect\u00f2niques que dona forma tridimensional al genoma. Recentment, personal investigador del CRG ha estudiat el paper d&#8217;aquesta prote\u00efna en diversos processos fonamentals.<\/p>\n","protected":false},"author":9,"featured_media":16094,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[265,289,329],"new-type":[35],"class_list":["post-16090","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-crg-ca","tag-genoma","tag-proteines","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/16090","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=16090"}],"version-history":[{"count":8,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/16090\/revisions"}],"predecessor-version":[{"id":16123,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/16090\/revisions\/16123"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/16094"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=16090"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=16090"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=16090"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=16090"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}