{"id":15296,"date":"2020-05-28T09:45:41","date_gmt":"2020-05-28T07:45:41","guid":{"rendered":"https:\/\/ellipse.prbb.org\/?p=15296"},"modified":"2020-05-28T09:45:56","modified_gmt":"2020-05-28T07:45:56","slug":"descubreixen-possibles-dianes-terapeutiques-per-tractar-la-infertilitat-i-el-cancer","status":"publish","type":"post","link":"https:\/\/ellipse.prbb.org\/ca\/descubreixen-possibles-dianes-terapeutiques-per-tractar-la-infertilitat-i-el-cancer\/","title":{"rendered":"Descubreixen possibles dianes terap\u00e8utiques per tractar la infertilitat i el c\u00e0ncer"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">El grup de recerca dirigit per Eva M. Novoa al <a rel=\"noreferrer noopener\" href=\"http:\/\/www.crg.eu\/\" target=\"_blank\">Centre de Regulaci\u00f3 Gen\u00f2mica (CRG)<\/a> ha dut a terme l&#8217;<strong>an\u00e0lisi evolutiva m\u00e9s completa<\/strong> a dia d&#8217;avui sobre les <strong>prote\u00efnes modificadores de l&#8217;ARN<\/strong> (<em>RNA-modifying proteins, <\/em>RMP). Han analitzat el seu comportament en unes 13.000 mostres de tumors humans, aix\u00ed com en 32 teixits diferents i en 10 esp\u00e8cies. I han trobat <a rel=\"noreferrer noopener\" href=\"https:\/\/www.crg.eu\/en\/news\/new-therapeutic-targets-infertility-and-cancer-revealed\" target=\"_blank\">alguns gens qe podrien ser <strong>possibles dianes terap\u00e8utiques pel tractament del c\u00e0ncer i la infertilitat masculina<\/strong><\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Els cient\u00edfics i cient\u00edfiques del CRG han observat que <strong>l&#8217;expressi\u00f3 de les RMP varia enormement entre els diferents tipus de teixits, i entre diferents tipus i estadis de c\u00e0ncer<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Els gens que codifiquen per les RMP se sobreexpressen especialment al <strong>teixit testicular<\/strong>. Si b\u00e9 la majoria d&#8217;aquests gens s&#8217;expressen durant les primeres etapes de formaci\u00f3 de l&#8217;esperma, d&#8217;altres ho fan a etapes posteriors, com les prote\u00efnes <strong>ADAD1<\/strong> o <strong>NSUN7<\/strong>. De fet, se sap que <strong>la seva disminuci\u00f3 provoca infertilitat<\/strong> i, per tant, ambdues prote\u00efnes es podrien utilitzar com possibles dianes terap\u00e8utiques pel tractament de la infertilitat masculina.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">D&#8217;altra banda, <strong>el 27% de totes les RMP humanes conegudes estan desregulades als c\u00e0ncers estudiats<\/strong>. Els dos gens que es van trobar m\u00e9s sobreexpresats en l&#8217;an\u00e0lisi van ser <strong>HENMT1<\/strong> i <strong>LAGE3<\/strong>. Aix\u00ed doncs, podrien ser tamb\u00e9 dianes terap\u00e8utiques prometedores pel desenvolupament de noves ter\u00e0pies antitumorals.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A d\u00eda d&#8217;avui, ja existeixen f\u00e0rmacs que utilitzen la maquin\u00e0ria de modificaci\u00f3 de l&#8217;ARN per a tractar tumors, tals com els glioblastomes.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><\/h2>\n","protected":false},"excerpt":{"rendered":"<p>Personal investigador del CRG comparteix el resultat del que \u00e9s l&#8217;an\u00e0lisi evolutiva m\u00e9s completa a dia d&#8217;avui sobre les prote\u00efnes modificadores de l&#8217;ARN.<\/p>\n","protected":false},"author":9,"featured_media":15305,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[26],"tags":[555,312,265,708,289],"new-type":[35],"class_list":["post-15296","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recerca","tag-arn","tag-cancer-ca","tag-crg-ca","tag-genetica","tag-genoma","new-type-noticies"],"acf":[],"_links":{"self":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/15296","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/comments?post=15296"}],"version-history":[{"count":16,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/15296\/revisions"}],"predecessor-version":[{"id":15341,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/posts\/15296\/revisions\/15341"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media\/15305"}],"wp:attachment":[{"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/media?parent=15296"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/categories?post=15296"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/tags?post=15296"},{"taxonomy":"new-type","embeddable":true,"href":"https:\/\/ellipse.prbb.org\/ca\/wp-json\/wp\/v2\/new-type?post=15296"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}